Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MED4
  • Mouse genes Med4
  • Rat genes Med4
  • Zfish genes med4
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Med4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0046966	nuclear thyroid hormone receptor binding	MED4	IDA		Human	PMID:10198638
Molecular Function	GO:0005515	protein binding	MED4	IPI	UniProtKB:Q9NWA0	Human	PMID:14638676
Molecular Function	GO:0005515	protein binding	MED4	IPI	UniProtKB:O95402	Human	PMID:15175163
Molecular Function	GO:0005515	protein binding	MED4	IPI	UniProtKB:Q9NWA0	Human	PMID:15175163
Molecular Function	GO:0005515	protein binding	MED4	IPI	UniProtKB:O95379	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	MED4	IPI	UniProtKB:Q96EZ8	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	MED4	IPI	UniProtKB:P61201	Human	PMID:17438371
Molecular Function	GO:0005515	protein binding	MED4	IPI	UniProtKB:Q93074	Human	PMID:21293490
Molecular Function	GO:0005515	protein binding	MED4	IPI	UniProtKB:O95402	Human	PMID:21729782
Molecular Function	GO:0005515	protein binding	MED4	IPI	UniProtKB:O95402	Human	PMID:24882805
Molecular Function	GO:0005515	protein binding	MED4	IPI	UniProtKB:Q13503	Human	PMID:24882805
Molecular Function	GO:0005515	protein binding	MED4	IPI	UniProtKB:Q9NWA0	Human	PMID:24882805
Molecular Function	GO:0005515	protein binding	MED4	IPI	UniProtKB:Q13503	Human	PMID:24981860
Molecular Function	GO:0005515	protein binding	MED4	IPI	UniProtKB:O14777	Human	PMID:25281560
Molecular Function	GO:0005515	protein binding	MED4	IPI	UniProtKB:O95402	Human	PMID:25281560
Molecular Function	GO:0005515	protein binding	MED4	IPI	UniProtKB:P40222	Human	PMID:25281560
Molecular Function	GO:0005515	protein binding	MED4	IPI	UniProtKB:Q13503	Human	PMID:25281560
Molecular Function	GO:0005515	protein binding	MED4	IPI	UniProtKB:Q8IY31	Human	PMID:25281560
Molecular Function	GO:0005515	protein binding	MED4	IPI	UniProtKB:Q93074	Human	PMID:25281560
Molecular Function	GO:0005515	protein binding	MED4	IPI	UniProtKB:Q96CS2	Human	PMID:25281560
Molecular Function	GO:0005515	protein binding	MED4	IPI	UniProtKB:Q9NWA0	Human	PMID:25281560
Molecular Function	GO:0005515	protein binding	MED4	IPI	UniProtKB:O00560	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	MED4	IPI	UniProtKB:O14777	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	MED4	IPI	UniProtKB:O95379	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	MED4	IPI	UniProtKB:O95954	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	MED4	IPI	UniProtKB:P40222	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	MED4	IPI	UniProtKB:Q08117	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	MED4	IPI	UniProtKB:Q32MZ4-4	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	MED4	IPI	UniProtKB:Q4VCS5-2	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	MED4	IPI	UniProtKB:Q8IY31	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	MED4	IPI	UniProtKB:Q8IYE0-2	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	MED4	IPI	UniProtKB:Q8N6Y0	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	MED4	IPI	UniProtKB:Q8N8X9	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	MED4	IPI	UniProtKB:Q8NE31	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	MED4	IPI	UniProtKB:Q8TAB5	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	MED4	IPI	UniProtKB:Q8TD31-3	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	MED4	IPI	UniProtKB:Q8WYA6	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	MED4	IPI	UniProtKB:Q969G3	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	MED4	IPI	UniProtKB:Q96CS2	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	MED4	IPI	UniProtKB:Q96ES7	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	MED4	IPI	UniProtKB:Q96GM5	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	MED4	IPI	UniProtKB:Q96NE9	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	MED4	IPI	UniProtKB:Q99909	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	MED4	IPI	UniProtKB:Q9BVG8	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	MED4	IPI	UniProtKB:Q93074	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	MED4	IPI	UniProtKB:Q13503	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	MED4	IPI	UniProtKB:Q8N3L3	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	MED4	IPI	UniProtKB:A2BDD9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MED4	IPI	UniProtKB:O14964	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MED4	IPI	UniProtKB:O43482	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MED4	IPI	UniProtKB:O95379	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MED4	IPI	UniProtKB:P40222	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MED4	IPI	UniProtKB:Q6PIF2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MED4	IPI	UniProtKB:Q8N3L3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MED4	IPI	UniProtKB:Q8N6Y0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MED4	IPI	UniProtKB:Q8TD31-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MED4	IPI	UniProtKB:Q8WVP5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MED4	IPI	UniProtKB:Q96CN9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MED4	IPI	UniProtKB:Q96EZ8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MED4	IPI	UniProtKB:Q96GM5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MED4	IPI	UniProtKB:Q96PC2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MED4	IPI	UniProtKB:Q99909	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MED4	IPI	UniProtKB:Q9BVG8-5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Med4	IPI	PR:Q8VCS6	Mouse	PMID:14638676
Molecular Function	GO:0003713	transcription coactivator activity	MED4	IDA		Human	PMID:12218053
Molecular Function	GO:0003712	transcription coregulator activity	MED4	IDA		Human	PMID:10882111
Cellular Component	GO:0070847	core mediator complex	MED4	IPI		Human	PMID:24882805
Cellular Component	GO:0016592	mediator complex	MED4	IDA		Human	PMID:10882111
Cellular Component	GO:0016592	mediator complex	MED4	IDA		Human	PMID:14638676
Cellular Component	GO:0016592	mediator complex	Med4	IDA		Mouse	PMID:15340084
Cellular Component	GO:0016020	membrane	MED4	HDA		Human	PMID:19946888
Cellular Component	GO:0005654	nucleoplasm	MED4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	MED4	IDA		Human	PMID:10235267
Cellular Component	GO:0005634	nucleus	MED4	IDA		Human	PMID:24882805
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	MED4	IDA		Human	PMID:10198638
Biological Process	GO:0060261	positive regulation of transcription initiation by RNA polymerase II	MED4	IDA		Human	PMID:12218053
Biological Process	GO:0006366	transcription by RNA polymerase II	MED4	IDA		Human	PMID:10882111

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern