Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Mef2d

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes MEF2D
- Mouse genes Mef2d
- Rat genes Mef2d
- Zfish genes mef2d
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Mef2d

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003677	DNA binding	Mef2d	IDA		Mouse	PMID:15491989
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Mef2d	IDA		Mouse	MGI:MGI:5572908\|PMID:7760790
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Mef2d	IDA		Mouse	PMID:12130539
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	MEF2D	IDA		Human	PMID:20590529
Molecular Function	GO:0140297	DNA-binding transcription factor binding	MEF2D	IPI	UniProtKB:Q02078	Human	PMID:20590529
Molecular Function	GO:0019899	enzyme binding	Mef2d	IPI	UniProtKB:Q6ZQ88	Mouse	MGI:MGI:4838688\|PMID:20833138
Molecular Function	GO:0042826	histone deacetylase binding	MEF2D	IPI	UniProtKB:Q13547	Human	PMID:20590529
Molecular Function	GO:0042826	histone deacetylase binding	Mef2d	IDA		Mouse	PMID:17158926
Molecular Function	GO:0005515	protein binding	MEF2D	IPI	UniProtKB:O15379	Human	PMID:21030595
Molecular Function	GO:0005515	protein binding	MEF2D	IPI	UniProtKB:Q8N163	Human	PMID:21030595
Molecular Function	GO:0005515	protein binding	Mef2d	IPI	PR:P23611	Mouse	PMID:25331958
Molecular Function	GO:0005515	protein binding	Mef2d	IPI	RGD:619980	Rat	PMID:7768895\|RGD:730001
Molecular Function	GO:0046982	protein heterodimerization activity	Mef2d	IPI	UniProtKB:Q02078\|UniProtKB:Q06413	Mouse	MGI:MGI:5142393\|PMID:9858528
Molecular Function	GO:0042803	protein homodimerization activity	Mef2d	IPI	UniProtKB:Q63943	Mouse	MGI:MGI:5142393\|PMID:9858528
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Mef2d	IDA		Mouse	MGI:MGI:5572908\|PMID:7760790
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	MEF2D	IDA		Human	PMID:20590529
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	MEF2D	IPI	UniProtKB:O96004	Human	PMID:16043483
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	MEF2D	IDA		Human	PMID:28473536
Molecular Function	GO:0000976	transcription cis-regulatory region binding	mef2d	IDA		Zfish	PMID:8951797
Cellular Component	GO:0005737	cytoplasm	Mef2d	IDA		Mouse	PMID:17158926
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	MEF2D	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	MEF2D	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	MEF2D	IDA		Human	PMID:20590529
Cellular Component	GO:0005634	nucleus	Mef2d	IDA		Mouse	PMID:15024082
Cellular Component	GO:0005634	nucleus	Mef2d	IDA		Mouse	PMID:17158926
Cellular Component	GO:0005634	nucleus	Mef2d	IDA		Mouse	PMID:15491989
Cellular Component	GO:0005634	nucleus	Mef2d	IDA		Rat	PMID:17696759\|RGD:8553739
Biological Process	GO:0007512	adult heart development	MEF2D	IEP		Human	PMID:10458488
Biological Process	GO:0002062	chondrocyte differentiation	Mef2d	IGI	MGI:MGI:99458	Mouse	PMID:17336904
Biological Process	GO:0001958	endochondral ossification	Mef2d	IGI	MGI:MGI:99458	Mouse	PMID:17336904
Biological Process	GO:0060914	heart formation	mef2d	IGI	ZFIN:ZDB-MRPHLNO-070730-5	Zfish	PMID:22750409
Biological Process	GO:0001649	osteoblast differentiation	Mef2d	IGI	MGI:MGI:99458	Mouse	PMID:17336904
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Mef2d	IDA		Mouse	PMID:9738004
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Mef2d	IMP		Rat	PMID:17696759\|RGD:8553739
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	MEF2D	IDA		Human	PMID:20590529
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Mef2d	IDA		Mouse	MGI:MGI:5572908\|PMID:7760790
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Mef2d	IGI	MGI:MGI:97276	Mouse	PMID:20399744
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Mef2d	IGI	MGI:MGI:99458	Mouse	PMID:18093911
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Mef2d	IGI	MGI:MGI:98510	Mouse	PMID:8900141
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Mef2d	IGI	MGI:MGI:96919	Mouse	PMID:8900141
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Mef2d	IDA		Mouse	PMID:17158926
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	mef2d	IDA		Zfish	PMID:8951797
Biological Process	GO:1904707	positive regulation of vascular associated smooth muscle cell proliferation	MEF2D	IGI	RNAcentral:URS0000355E82_9606	Human	PMID:29118903
Biological Process	GO:0006355	regulation of DNA-templated transcription	Mef2d	IDA		Mouse	PMID:12130539
Biological Process	GO:0035914	skeletal muscle cell differentiation	Mef2d	IMP		Mouse	PMID:22147266
Biological Process	GO:0030241	skeletal muscle myosin thick filament assembly	mef2d	IGI	ZFIN:ZDB-GENE-980526-253,ZFIN:ZDB-MRPHLNO-070730-5	Zfish	PMID:17537787

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.