Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MEFV
  • Mouse genes Mefv
  • Rat genes Mefv
  • Zfish genes si:ch211-114c12.5,si:ch211-120g10.1,si:ch73-364h19.2,si:dkey-18p12.4,si:dkey-219e21.2,zgc:194990
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Mefv

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003779	actin binding	MEFV	IDA		Human	PMID:11468188
Molecular Function	GO:0042802	identical protein binding	MEFV	IPI	UniProtKB:O15553	Human	PMID:17964261
Molecular Function	GO:0042802	identical protein binding	MEFV	IPI	UniProtKB:O15553	Human	PMID:22829933
Molecular Function	GO:0042802	identical protein binding	MEFV	IPI	UniProtKB:O15553	Human	PMID:25006247
Molecular Function	GO:0005515	protein binding	MEFV	IPI	UniProtKB:Q9ULZ3	Human	PMID:11498534
Molecular Function	GO:0005515	protein binding	MEFV	IPI	UniProtKB:P29466	Human	PMID:16785446
Molecular Function	GO:0005515	protein binding	MEFV	IPI	UniProtKB:O43586	Human	PMID:17964261
Molecular Function	GO:0005515	protein binding	MEFV	IPI	UniProtKB:Q9ULZ3	Human	PMID:17964261
Molecular Function	GO:0005515	protein binding	MEFV	IPI	UniProtKB:Q9ULZ3	Human	PMID:25006247
Molecular Function	GO:0005515	protein binding	MEFV	IPI	UniProtKB:O95166	Human	PMID:25127057
Molecular Function	GO:0005515	protein binding	MEFV	IPI	UniProtKB:Q9H492	Human	PMID:25127057
Molecular Function	GO:0005515	protein binding	MEFV	IPI	UniProtKB:O75385|UniProtKB:O95166|UniProtKB:P19474|UniProtKB:P60520|UniProtKB:Q14457|UniProtKB:Q676U5|UniProtKB:Q96P20|UniProtKB:Q9BXW4|UniProtKB:Q9H0R8|UniProtKB:Q9H492	Human	PMID:26347139
Molecular Function	GO:0005515	protein binding	MEFV	IPI	UniProtKB:P27348|UniProtKB:P31946|UniProtKB:P61981|UniProtKB:P62258|UniProtKB:P63104|UniProtKB:Q04917	Human	PMID:27030597
Cellular Component	GO:0061702	canonical inflammasome complex	MEFV	IPI		Human	PMID:16037825
Cellular Component	GO:0005737	cytoplasm	MEFV	IDA		Human	PMID:26347139
Cellular Component	GO:0005829	cytosol	MEFV	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005875	microtubule associated complex	MEFV	IDA		Human	PMID:11468188
Cellular Component	GO:0005654	nucleoplasm	MEFV	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	MEFV	IDA		Human	PMID:11115844
Biological Process	GO:0006954	inflammatory response	MEFV	IDA		Human	PMID:11468188
Biological Process	GO:1900016	negative regulation of cytokine production involved in inflammatory response	MEFV	IMP		Human	PMID:26347139
Biological Process	GO:0050728	negative regulation of inflammatory response	MEFV	IMP		Human	PMID:16403826
Biological Process	GO:0032691	negative regulation of interleukin-1 beta production	MEFV	IMP		Human	PMID:20041150
Biological Process	GO:0032695	negative regulation of interleukin-12 production	MEFV	IMP		Human	PMID:20041150
Biological Process	GO:0071641	negative regulation of macrophage inflammatory protein 1 alpha production	MEFV	IMP		Human	PMID:20041150
Biological Process	GO:1900226	negative regulation of NLRP3 inflammasome complex assembly	MEFV	IMP		Human	PMID:26347139
Biological Process	GO:0010508	positive regulation of autophagy	MEFV	IDA		Human	PMID:26347139
Biological Process	GO:2001056	positive regulation of cysteine-type endopeptidase activity	MEFV	IDA		Human	PMID:19158676
Biological Process	GO:0050729	positive regulation of inflammatory response	Mefv	IDA		Mouse	MGI:MGI:6141801|PMID:27270401
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	MEFV	IDA		Human	PMID:16037825
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	Mefv	IDA		Mouse	MGI:MGI:6141801|PMID:27270401
Biological Process	GO:1904270	pyroptosome complex assembly	MEFV	IDA		Human	PMID:27030597
Biological Process	GO:0032651	regulation of interleukin-1 beta production	MEFV	IMP		Human	PMID:27030597
Biological Process	GO:0032496	response to lipopolysaccharide	Mefv	IEP		Rat	PMID:16574623|RGD:7349342
Biological Process	GO:0034021	response to silicon dioxide	Mefv	IEP		Rat	PMID:16574623|RGD:7349342
Biological Process	GO:0034341	response to type II interferon	MEFV	IDA		Human	PMID:26347139

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern