Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MEGF8
  • Mouse genes Megf8
  • Rat genes Megf8
  • Zfish genes megf8
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Megf8

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	MEGF8	IPI	UniProtKB:O00555	Human	PMID:21078624
Molecular Function	GO:0005515	protein binding	MEGF8	IPI	UniProtKB:O15265	Human	PMID:21078624
Cellular Component	GO:0070062	extracellular exosome	MEGF8	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	MEGF8	HDA		Human	PMID:23533145
Cellular Component	GO:0005634	nucleus	Megf8	IDA		Mouse	PMID:19218456
Biological Process	GO:0030509	BMP signaling pathway	Megf8	IGI	UniProtKB:O35607	Mouse	MGI:MGI:5551355|PMID:24052814
Biological Process	GO:0042074	cell migration involved in gastrulation	MEGF8	IMP		Human	PMID:23063620
Biological Process	GO:0042074	cell migration involved in gastrulation	megf8	IMP	ZFIN:ZDB-MRPHLNO-090424-3	Zfish	PMID:23063620
Biological Process	GO:0060976	coronary vasculature development	Megf8	IMP		Mouse	PMID:25807483
Biological Process	GO:0097094	craniofacial suture morphogenesis	MEGF8	IMP		Human	PMID:23063620
Biological Process	GO:0071907	determination of digestive tract left/right asymmetry	Megf8	IMP	MGI:MGI:3722325	Mouse	PMID:18043505
Biological Process	GO:0061371	determination of heart left/right asymmetry	MEGF8	IMP		Human	PMID:23063620
Biological Process	GO:0061371	determination of heart left/right asymmetry	Megf8	IMP	MGI:MGI:3722325	Mouse	PMID:18043505
Biological Process	GO:0007368	determination of left/right symmetry	Megf8	IMP		Mouse	PMID:25807483
Biological Process	GO:0007368	determination of left/right symmetry	megf8	IMP	ZFIN:ZDB-MRPHLNO-090424-2	Zfish	PMID:19218456
Biological Process	GO:0060971	embryonic heart tube left/right pattern formation	Megf8	IMP		Mouse	MGI:MGI:5551355|PMID:24052814
Biological Process	GO:0003143	embryonic heart tube morphogenesis	Megf8	IMP		Mouse	MGI:MGI:5551355|PMID:24052814
Biological Process	GO:0030326	embryonic limb morphogenesis	Megf8	IMP		Mouse	MGI:MGI:5551355|PMID:24052814
Biological Process	GO:0048704	embryonic skeletal system morphogenesis	Megf8	IMP		Mouse	MGI:MGI:5551355|PMID:24052814
Biological Process	GO:0055113	epiboly involved in gastrulation with mouth forming second	MEGF8	IMP		Human	PMID:23063620
Biological Process	GO:0055113	epiboly involved in gastrulation with mouth forming second	megf8	IMP	ZFIN:ZDB-MRPHLNO-090424-3	Zfish	PMID:23063620
Biological Process	GO:0097155	fasciculation of sensory neuron axon	Megf8	IMP		Mouse	MGI:MGI:5551355|PMID:24052814
Biological Process	GO:0060972	left/right pattern formation	MEGF8	IMP		Human	PMID:23063620
Biological Process	GO:0060972	left/right pattern formation	Megf8	IMP		Mouse	MGI:MGI:5551355|PMID:24052814
Biological Process	GO:0060972	left/right pattern formation	megf8	IMP		Zfish	PMID:23063620|ZFIN:ZDB-PUB-121019-24
Biological Process	GO:0035108	limb morphogenesis	MEGF8	IMP		Human	PMID:23063620
Biological Process	GO:0045879	negative regulation of smoothened signaling pathway	Megf8	IMP		Mouse	MGI:MGI:6111022|PMID:29290584
Biological Process	GO:0048842	positive regulation of axon extension involved in axon guidance	Megf8	IMP		Mouse	MGI:MGI:5551355|PMID:24052814
Biological Process	GO:0010468	regulation of gene expression	Megf8	IMP		Mouse	MGI:MGI:5551355|PMID:24052814

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern