Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MEIS1
  • Mouse genes Meis1
  • Rat genes Meis1
  • Zfish genes meis1a,meis1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Meis1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003682	chromatin binding	Meis1	IDA		Mouse	PMID:19268698
Molecular Function	GO:0003677	DNA binding	MEIS1	IDA		Human	PMID:26550823
Molecular Function	GO:0003677	DNA binding	Meis1	IDA		Mouse	PMID:9343407
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Meis1	IDA		Mouse	MGI:MGI:5574299|PMID:19799567
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	Meis1	IDA		Mouse	PMID:10373562
Molecular Function	GO:0005515	protein binding	MEIS1	IPI	UniProtKB:P14921	Human	PMID:18692240
Molecular Function	GO:0005515	protein binding	MEIS1	IPI	UniProtKB:P31314	Human	PMID:19559479
Molecular Function	GO:0005515	protein binding	MEIS1	IPI	UniProtKB:P16220	Human	PMID:20159610
Molecular Function	GO:0005515	protein binding	MEIS1	IPI	UniProtKB:P40424	Human	PMID:20211142
Molecular Function	GO:0005515	protein binding	MEIS1	IPI	UniProtKB:P16220	Human	PMID:20541704
Molecular Function	GO:0005515	protein binding	MEIS1	IPI	UniProtKB:P40424	Human	PMID:20541704
Molecular Function	GO:0005515	protein binding	Meis1	IPI	PR:P41778	Mouse	PMID:9315626
Molecular Function	GO:0005515	protein binding	Meis1	IPI	PR:P41778	Mouse	PMID:9405651
Molecular Function	GO:0005515	protein binding	Meis1	IPI	PR:P70321	Mouse	PMID:9343407
Molecular Function	GO:0005515	protein binding	Meis1	IPI	PR:P23812	Mouse	PMID:9343407
Molecular Function	GO:0005515	protein binding	Meis1	IPI	PR:O70477	Mouse	PMID:10373562
Molecular Function	GO:0005515	protein binding	Meis1	IPI	PR:P09631	Mouse	PMID:9343407
Molecular Function	GO:0005515	protein binding	meis1b	IPI	ZFIN:ZDB-GENE-000201-18	Zfish	PMID:11684652
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Meis1	IDA		Mouse	MGI:MGI:5574299|PMID:19799567
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Meis1	IDA		Mouse	PMID:9405651
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Meis1	IDA		Mouse	PMID:12183364
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Meis1	IDA		Mouse	PMID:15465489
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Meis1	IDA		Mouse	PMID:17056599
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Meis1	IDA		Mouse	PMID:9315626
Molecular Function	GO:0043565	sequence-specific DNA binding	Meis1	IGI	MGI:MGI:97495	Mouse	PMID:17049510
Molecular Function	GO:0043565	sequence-specific DNA binding	Meis1	IDA		Mouse	PMID:15634706
Cellular Component	GO:0005829	cytosol	meis1b	IDA		Zfish	PMID:21048033|ZFIN:ZDB-PUB-101108-31
Cellular Component	GO:0005634	nucleus	Meis1	IDA		Mouse	PMID:15617687
Cellular Component	GO:0005634	nucleus	Meis1	IDA		Mouse	PMID:17049510
Cellular Component	GO:0005634	nucleus	Meis1	IDA		Mouse	PMID:17178831
Cellular Component	GO:0005634	nucleus	Meis1	IDA		Mouse	PMID:9315626
Cellular Component	GO:0005634	nucleus	Meis1	IDA		Mouse	PMID:21059917
Cellular Component	GO:0005634	nucleus	Meis1	IDA		Mouse	PMID:10842069
Cellular Component	GO:0005634	nucleus	meis1b	IDA		Zfish	PMID:21048033|ZFIN:ZDB-PUB-101108-31
Cellular Component	GO:0005667	transcription regulator complex	Meis1	IDA		Mouse	PMID:9405651
Cellular Component	GO:0005667	transcription regulator complex	Meis1	IDA		Mouse	PMID:9343407
Cellular Component	GO:0005667	transcription regulator complex	Meis1	IDA		Mouse	PMID:12183364
Cellular Component	GO:0005667	transcription regulator complex	Meis1	IDA		Mouse	PMID:10373562
Biological Process	GO:0035476	angioblast cell migration	meis1b	IMP		Zfish	PMID:21048033|ZFIN:ZDB-PUB-101108-31
Biological Process	GO:0001525	angiogenesis	Meis1	IMP	MGI:MGI:3029063	Mouse	PMID:14713950
Biological Process	GO:0001525	angiogenesis	meis1b	IMP	ZFIN:ZDB-MRPHLNO-090107-1	Zfish	PMID:18656453
Biological Process	GO:0048844	artery morphogenesis	meis1b	IMP	ZFIN:ZDB-MRPHLNO-090107-1	Zfish	PMID:18656453
Biological Process	GO:0072554	blood vessel lumenization	meis1b	IMP		Zfish	PMID:21048033|ZFIN:ZDB-PUB-101108-31
Biological Process	GO:0048514	blood vessel morphogenesis	Meis1	IMP	MGI:MGI:3578637	Mouse	PMID:15882575
Biological Process	GO:0007420	brain development	meis1a	IGI	ZFIN:ZDB-MRPHLNO-141229-5	Zfish	PMID:24995868
Biological Process	GO:0007420	brain development	meis1a	IGI	ZFIN:ZDB-MRPHLNO-110216-1	Zfish	PMID:24995868
Biological Process	GO:0061049	cell growth involved in cardiac muscle cell development	Meis1	IMP		Rat	PMID:26597775|RGD:11554891
Biological Process	GO:0060216	definitive hemopoiesis	Meis1	IMP	MGI:MGI:3578637	Mouse	PMID:15882575
Biological Process	GO:0060216	definitive hemopoiesis	meis1b	IMP		Zfish	PMID:21048033|ZFIN:ZDB-PUB-101108-31
Biological Process	GO:0060216	definitive hemopoiesis	meis1b	IGI	ZFIN:ZDB-MIRNAG-090929-155	Zfish	PMID:24448023
Biological Process	GO:0035907	dorsal aorta development	meis1b	IMP		Zfish	PMID:21048033|ZFIN:ZDB-PUB-101108-31
Biological Process	GO:0009880	embryonic pattern specification	meis1b	IMP	ZFIN:ZDB-MRPHLNO-071025-2	Zfish	PMID:20809932
Biological Process	GO:0060059	embryonic retina morphogenesis in camera-type eye	meis1b	IMP	ZFIN:ZDB-MRPHLNO-071025-2	Zfish	PMID:20809932
Biological Process	GO:0060059	embryonic retina morphogenesis in camera-type eye	meis1b	IMP	ZFIN:ZDB-MRPHLNO-071025-2	Zfish	PMID:17634100
Biological Process	GO:0048703	embryonic viscerocranium morphogenesis	meis1b	IMP	ZFIN:ZDB-MRPHLNO-090107-1	Zfish	PMID:23559552
Biological Process	GO:0048703	embryonic viscerocranium morphogenesis	meis1b	IMP	ZFIN:ZDB-MRPHLNO-090107-1,ZFIN:ZDB-MRPHLNO-130729-1	Zfish	PMID:23559552
Biological Process	GO:0001885	endothelial cell development	meis1b	IMP	ZFIN:ZDB-MRPHLNO-090107-1	Zfish	PMID:18656453
Biological Process	GO:0000082	G1/S transition of mitotic cell cycle	meis1b	IMP	ZFIN:ZDB-MRPHLNO-071025-2	Zfish	PMID:18216175
Biological Process	GO:0001947	heart looping	meis1b	IMP	ZFIN:ZDB-MRPHLNO-090107-1	Zfish	PMID:18656453
Biological Process	GO:0030097	hemopoiesis	Meis1	IMP	MGI:MGI:3029063	Mouse	PMID:14713950
Biological Process	GO:0002089	lens morphogenesis in camera-type eye	Meis1	IMP	MGI:MGI:3029063	Mouse	PMID:14713950
Biological Process	GO:0007626	locomotory behavior	Meis1	IMP	MGI:MGI:3578637	Mouse	PMID:24642863
Biological Process	GO:0030225	macrophage differentiation	meis1b	IMP		Zfish	PMID:21048033|ZFIN:ZDB-PUB-101108-31
Biological Process	GO:0035855	megakaryocyte development	Meis1	IMP	MGI:MGI:3578637	Mouse	PMID:20203303
Biological Process	GO:0045638	negative regulation of myeloid cell differentiation	Meis1	IDA		Mouse	MGI:MGI:5447628|PMID:11438208
Biological Process	GO:0045665	negative regulation of neuron differentiation	Meis1	IGI	MGI:MGI:96174	Mouse	PMID:18164701
Biological Process	GO:0045665	negative regulation of neuron differentiation	Meis1	IGI	MGI:MGI:97495	Mouse	PMID:18164701
Biological Process	GO:0030223	neutrophil differentiation	meis1b	IMP		Zfish	PMID:21048033|ZFIN:ZDB-PUB-101108-31
Biological Process	GO:0045766	positive regulation of angiogenesis	meis1b	IDA		Zfish	PMID:21048033|ZFIN:ZDB-PUB-101108-31
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Meis1	IDA		Mouse	MGI:MGI:5574299|PMID:19799567
Biological Process	GO:0060319	primitive erythrocyte differentiation	meis1b	IMP		Zfish	PMID:21048033|ZFIN:ZDB-PUB-101108-31
Biological Process	GO:0060215	primitive hemopoiesis	meis1b	IGI	ZFIN:ZDB-MIRNAG-090929-155	Zfish	PMID:24448023
Biological Process	GO:0050821	protein stabilization	meis1b	IPI	ZFIN:ZDB-GENE-000201-18	Zfish	PMID:11684652
Biological Process	GO:0006355	regulation of DNA-templated transcription	Meis1	IDA		Mouse	PMID:12183364
Biological Process	GO:0001944	vasculature development	meis1b	IGI	ZFIN:ZDB-MIRNAG-090929-155	Zfish	PMID:24448023
Biological Process	GO:0060841	venous blood vessel development	meis1b	IMP		Zfish	PMID:21048033|ZFIN:ZDB-PUB-101108-31

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern