Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MEIS2
  • Mouse genes Meis2
  • Rat genes Meis2
  • Zfish genes meis2a,meis2b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Meis2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003677	DNA binding	MEIS2	IDA		Human	PMID:26550823
Molecular Function	GO:0003677	DNA binding	Meis2	IDA		Mouse	PMID:12183364
Molecular Function	GO:0003677	DNA binding	Meis2	IDA		Mouse	PMID:15465489
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	MEIS2	IDA		Human	PMID:10764806
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Meis2	IDA		Mouse	MGI:MGI:3694141|PMID:11279116
Molecular Function	GO:0005515	protein binding	MEIS2	IPI	UniProtKB:P03363	Human	PMID:22458338
Molecular Function	GO:0005515	protein binding	MEIS2	IPI	UniProtKB:A0A1B0GWI1	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	MEIS2	IPI	UniProtKB:Q5TZZ9	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	MEIS2	IPI	UniProtKB:Q6P1W5	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	MEIS2	IPI	UniProtKB:Q9UJX0	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	MEIS2	IPI	UniProtKB:Q9UJX0	Human	PMID:31515488
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	MEIS2	IDA		Human	PMID:10764806
Molecular Function	GO:0043565	sequence-specific DNA binding	Meis2	IGI	MGI:MGI:97495	Mouse	PMID:17049510
Molecular Function	GO:0043565	sequence-specific DNA binding	Meis2	IDA		Mouse	PMID:18787068
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	MEIS2	IDA		Human	PMID:28473536
Molecular Function	GO:0008134	transcription factor binding	Meis2	IDA		Mouse	MGI:MGI:3694141|PMID:11279116
Molecular Function	GO:0008134	transcription factor binding	Meis2	IDA		Mouse	MGI:MGI:5447628|PMID:11438208
Cellular Component	GO:0005634	nucleus	Meis2	IDA		Mouse	PMID:10842069
Cellular Component	GO:0005634	nucleus	Meis2	IDA		Mouse	PMID:15617687
Cellular Component	GO:0005634	nucleus	Meis2	IDA		Mouse	PMID:17178831
Cellular Component	GO:0005634	nucleus	Meis2	IDA		Mouse	PMID:11358480
Cellular Component	GO:0005634	nucleus	Meis2	IDA		Mouse	PMID:17049510
Cellular Component	GO:0005634	nucleus	Meis2	IDA		Rat	PMID:17235568|RGD:2311225
Biological Process	GO:0003209	cardiac atrium morphogenesis	meis2b	IMP	ZFIN:ZDB-GENO-180921-3	Zfish	PMID:29762122
Biological Process	GO:0048703	embryonic viscerocranium morphogenesis	meis2a	IMP	ZFIN:ZDB-MRPHLNO-130802-2	Zfish	PMID:23559552
Biological Process	GO:0001654	eye development	Meis2	IGI	MGI:MGI:97490	Mouse	PMID:12183364
Biological Process	GO:0007507	heart development	meis2b	IMP	ZFIN:ZDB-MRPHLNO-121026-1	Zfish	PMID:22981225
Biological Process	GO:0007507	heart development	meis2b	IMP	ZFIN:ZDB-MRPHLNO-121030-7	Zfish	PMID:22981225
Biological Process	GO:0001947	heart looping	meis2b	IMP	ZFIN:ZDB-MRPHLNO-121026-1	Zfish	PMID:22981225
Biological Process	GO:0001947	heart looping	meis2b	IMP	ZFIN:ZDB-MRPHLNO-121030-7	Zfish	PMID:22981225
Biological Process	GO:0045638	negative regulation of myeloid cell differentiation	Meis2	IDA		Mouse	MGI:MGI:5447628|PMID:11438208
Biological Process	GO:0031016	pancreas development	Meis2	IEP		Rat	PMID:15660282|RGD:2304272
Biological Process	GO:0110024	positive regulation of cardiac muscle myoblast proliferation	MEIS2	IDA		Human	PMID:26512644
Biological Process	GO:0045931	positive regulation of mitotic cell cycle	MEIS2	IDA		Human	PMID:26512644
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	MEIS2	IDA		Human	PMID:10764806
Biological Process	GO:0070848	response to growth factor	Meis2	IEP		Rat	PMID:12823474|RGD:2304270
Biological Process	GO:0009612	response to mechanical stimulus	Meis2	IEP		Rat	PMID:15660282|RGD:2304272
Biological Process	GO:0008542	visual learning	Meis2	IMP		Mouse	PMID:25834037

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern