Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MESP1
  • Mouse genes Mesp1
  • Rat genes Mesp1
  • Zfish genes mesp1,mespaa,mespab,mespba,mespbb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Mesp1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0000987	cis-regulatory region sequence-specific DNA binding	Mesp1	IDA		Mouse	MGI:MGI:4441249|PMID:18593560
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Mesp1	IDA		Mouse	MGI:MGI:3835736|PMID:18297060
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Mesp1	IMP		Mouse	MGI:MGI:3835736|PMID:18297060
Molecular Function	GO:0003700	DNA-binding transcription factor activity	MESP1	IDA		Human	PMID:18297060
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Mesp1	IMP		Mouse	MGI:MGI:3835736|PMID:18297060
Molecular Function	GO:0005515	protein binding	MESP1	IPI	UniProtKB:Q7Z699	Human	PMID:32814053
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Mesp1	IDA		Mouse	MGI:MGI:3835736|PMID:18297060
Molecular Function	GO:0000976	transcription cis-regulatory region binding	MESP1	IDA		Human	PMID:18297060
Cellular Component	GO:0005634	nucleus	Mesp1	IDA		Mouse	MGI:MGI:4441249|PMID:18593560
Biological Process	GO:0009952	anterior/posterior pattern specification	mespba	IMP		Zfish	PMID:10725245
Biological Process	GO:0097101	blood vessel endothelial cell fate specification	mespaa	IMP		Zfish	PMID:27554166
Biological Process	GO:0097101	blood vessel endothelial cell fate specification	mespba	IMP		Zfish	PMID:27554166
Biological Process	GO:0097101	blood vessel endothelial cell fate specification	mespbb	IMP		Zfish	PMID:27554166
Biological Process	GO:0003210	cardiac atrium formation	MESP1	IMP		Human	PMID:18297060
Biological Process	GO:0060913	cardiac cell fate determination	Mesp1	IDA		Mouse	MGI:MGI:4441249|PMID:18593560
Biological Process	GO:0055007	cardiac muscle cell differentiation	MESP1	IMP		Human	PMID:18297060
Biological Process	GO:0060947	cardiac vascular smooth muscle cell differentiation	MESP1	IMP		Human	PMID:18297060
Biological Process	GO:0003211	cardiac ventricle formation	MESP1	IMP		Human	PMID:18297060
Biological Process	GO:0003259	cardioblast anterior-lateral migration	Mesp1	IEP		Mouse	MGI:MGI:3835736|PMID:18297060
Biological Process	GO:0003260	cardioblast migration	Mesp1	IMP	MGI:MGI:2182080	Mouse	PMID:10393122
Biological Process	GO:0060975	cardioblast migration to the midline involved in heart field formation	Mesp1	IMP		Mouse	MGI:MGI:1339460|PMID:10393122
Biological Process	GO:0061371	determination of heart left/right asymmetry	mespaa	IGI	ZFIN:ZDB-GENO-161206-2,ZFIN:ZDB-MRPHLNO-161122-1	Zfish	PMID:27554166
Biological Process	GO:0061371	determination of heart left/right asymmetry	mespaa	IGI	ZFIN:ZDB-GENO-161206-2,ZFIN:ZDB-MRPHLNO-161122-2	Zfish	PMID:27554166
Biological Process	GO:0061371	determination of heart left/right asymmetry	mespaa	IMP	ZFIN:ZDB-GENO-161206-2	Zfish	PMID:27554166
Biological Process	GO:0061371	determination of heart left/right asymmetry	mespaa	IGI	ZFIN:ZDB-GENO-161206-2,ZFIN:ZDB-MRPHLNO-060113-7	Zfish	PMID:27554166
Biological Process	GO:0061371	determination of heart left/right asymmetry	mespba	IGI	ZFIN:ZDB-GENO-161206-2,ZFIN:ZDB-MRPHLNO-060113-7	Zfish	PMID:27554166
Biological Process	GO:0061371	determination of heart left/right asymmetry	mespab	IGI	ZFIN:ZDB-GENO-161206-2,ZFIN:ZDB-MRPHLNO-161122-1	Zfish	PMID:27554166
Biological Process	GO:0061371	determination of heart left/right asymmetry	mespbb	IGI	ZFIN:ZDB-GENO-161206-2,ZFIN:ZDB-MRPHLNO-161122-2	Zfish	PMID:27554166
Biological Process	GO:0003143	embryonic heart tube morphogenesis	Mesp1	IMP		Mouse	MGI:MGI:1339460|PMID:10393122
Biological Process	GO:0045446	endothelial cell differentiation	MESP1	IMP		Human	PMID:18297060
Biological Process	GO:0007369	gastrulation	Mesp1	IEP		Mouse	MGI:MGI:83220|PMID:8787751
Biological Process	GO:0001702	gastrulation with mouth forming second	mespaa	IMP		Zfish	PMID:10725245
Biological Process	GO:0010467	gene expression	Mesp1	IMP		Mouse	PMID:23352431
Biological Process	GO:0003241	growth involved in heart morphogenesis	Mesp1	IMP		Mouse	MGI:MGI:1339460|PMID:10393122
Biological Process	GO:0003128	heart field specification	mespaa	IMP		Zfish	PMID:27554166
Biological Process	GO:0001947	heart looping	Mesp1	IMP		Mouse	MGI:MGI:1339460|PMID:10393122
Biological Process	GO:0003007	heart morphogenesis	Mesp1	IMP	MGI:MGI:2182080	Mouse	PMID:10393122
Biological Process	GO:0048368	lateral mesoderm development	Mesp1	IEP		Mouse	MGI:MGI:1339460|PMID:10393122
Biological Process	GO:0001707	mesoderm formation	mespaa	IMP		Zfish	PMID:10725245
Biological Process	GO:0008078	mesodermal cell migration	Mesp1	IGI	MGI:MGI:1096325	Mouse	PMID:10393122
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Mesp1	IDA		Mouse	MGI:MGI:4441249|PMID:18593560
Biological Process	GO:0042664	negative regulation of endodermal cell fate specification	Mesp1	IDA		Mouse	MGI:MGI:4441249|PMID:18593560
Biological Process	GO:0042662	negative regulation of mesodermal cell fate specification	Mesp1	IDA		Mouse	MGI:MGI:4441249|PMID:18593560
Biological Process	GO:0022008	neurogenesis	MESP1	IMP		Human	PMID:18297060
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Mesp1	IDA		Mouse	MGI:MGI:4441249|PMID:18593560
Biological Process	GO:0090082	positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway	Mesp1	IDA		Mouse	MGI:MGI:3835736|PMID:18297060
Biological Process	GO:0070368	positive regulation of hepatocyte differentiation	Mesp1	IDA		Mouse	MGI:MGI:4441249|PMID:18593560
Biological Process	GO:0045747	positive regulation of Notch signaling pathway	Mesp1	IDA		Mouse	MGI:MGI:4441249|PMID:18593560
Biological Process	GO:0035481	positive regulation of Notch signaling pathway involved in heart induction	Mesp1	IDA		Mouse	MGI:MGI:4441249|PMID:18593560
Biological Process	GO:0051155	positive regulation of striated muscle cell differentiation	Mesp1	IDA		Mouse	MGI:MGI:4441249|PMID:18593560
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	MESP1	IDA		Human	PMID:18297060
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Mesp1	IMP		Mouse	MGI:MGI:3835736|PMID:18297060
Biological Process	GO:0048641	regulation of skeletal muscle tissue development	mespba	IGI	ZFIN:ZDB-GENO-160517-1	Zfish	PMID:25725067
Biological Process	GO:0048641	regulation of skeletal muscle tissue development	mespba	IGI	ZFIN:ZDB-MRPHLNO-060113-7,ZFIN:ZDB-MRPHLNO-150603-3	Zfish	PMID:25725067
Biological Process	GO:0048641	regulation of skeletal muscle tissue development	mespba	IGI	ZFIN:ZDB-GENO-160517-2	Zfish	PMID:25725067
Biological Process	GO:0048641	regulation of skeletal muscle tissue development	mespbb	IGI	ZFIN:ZDB-MRPHLNO-060113-7,ZFIN:ZDB-MRPHLNO-150603-3	Zfish	PMID:25725067
Biological Process	GO:0032526	response to retinoic acid	mespaa	IDA		Zfish	PMID:18261720
Biological Process	GO:0032526	response to retinoic acid	mespba	IDA		Zfish	PMID:18261720
Biological Process	GO:0003139	secondary heart field specification	Mesp1	IDA		Mouse	MGI:MGI:4441249|PMID:18593560
Biological Process	GO:0023019	signal transduction involved in regulation of gene expression	Mesp1	IDA		Mouse	PMID:18462699
Biological Process	GO:0060921	sinoatrial node cell differentiation	MESP1	IMP		Human	PMID:18297060
Biological Process	GO:0003236	sinus venosus morphogenesis	Mesp1	IMP		Mouse	MGI:MGI:1339460|PMID:10393122
Biological Process	GO:0032525	somite rostral/caudal axis specification	mespaa	IGI	ZFIN:ZDB-GENO-161208-3	Zfish	PMID:27385009
Biological Process	GO:0032525	somite rostral/caudal axis specification	mespba	IGI	ZFIN:ZDB-GENO-161208-3	Zfish	PMID:27385009
Biological Process	GO:0032525	somite rostral/caudal axis specification	mespab	IGI	ZFIN:ZDB-GENO-161208-3	Zfish	PMID:27385009
Biological Process	GO:0032525	somite rostral/caudal axis specification	mespbb	IGI	ZFIN:ZDB-GENO-161208-3	Zfish	PMID:27385009
Biological Process	GO:0001757	somite specification	mespaa	IGI	ZFIN:ZDB-GENO-161208-3	Zfish	PMID:27385009
Biological Process	GO:0001757	somite specification	mespba	IGI	ZFIN:ZDB-GENO-161208-3	Zfish	PMID:27385009
Biological Process	GO:0001757	somite specification	mespab	IGI	ZFIN:ZDB-GENO-161208-3	Zfish	PMID:27385009
Biological Process	GO:0001757	somite specification	mespbb	IGI	ZFIN:ZDB-GENO-161208-3	Zfish	PMID:27385009
Biological Process	GO:0001756	somitogenesis	mespba	IMP		Zfish	PMID:10725245
Biological Process	GO:0001756	somitogenesis	mespba	IMP	ZFIN:ZDB-MRPHLNO-060113-7	Zfish	PMID:16326386

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern