Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Mettl14

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes METTL14
- Mouse genes Mettl14
- Rat genes Mettl14
- Zfish genes mettl14
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Mettl14

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001734	mRNA (N6-adenosine)-methyltransferase activity	METTL14	IDA		Human	PMID:24316715
Molecular Function	GO:0001734	mRNA (N6-adenosine)-methyltransferase activity	Mettl14	IDA		Mouse	MGI:MGI:5559905\|PMID:24394384
Molecular Function	GO:0003729	mRNA binding	METTL14	IDA		Human	PMID:27281194
Molecular Function	GO:0003729	mRNA binding	METTL14	IDA		Human	PMID:27373337
Molecular Function	GO:0003729	mRNA binding	METTL14	IDA		Human	PMID:27627798
Molecular Function	GO:0005515	protein binding	METTL14	IPI	UniProtKB:Q15007-1	Human	PMID:24316715
Molecular Function	GO:0005515	protein binding	METTL14	IPI	UniProtKB:Q86U44	Human	PMID:24316715
Molecular Function	GO:0005515	protein binding	METTL14	IPI	UniProtKB:Q86U44-1	Human	PMID:24316715
Molecular Function	GO:0005515	protein binding	METTL14	IPI	UniProtKB:Q86U44	Human	PMID:24394384
Molecular Function	GO:0005515	protein binding	METTL14	IPI	UniProtKB:Q86U44	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	METTL14	IPI	UniProtKB:Q86U44	Human	PMID:27281194
Molecular Function	GO:0005515	protein binding	METTL14	IPI	UniProtKB:Q86U44-1	Human	PMID:27281194
Molecular Function	GO:0005515	protein binding	METTL14	IPI	UniProtKB:Q86U44	Human	PMID:27373337
Molecular Function	GO:0005515	protein binding	METTL14	IPI	UniProtKB:Q86U44	Human	PMID:29507755
Molecular Function	GO:0005515	protein binding	Mettl14	IPI	UniProtKB:Q8C3P7	Mouse	MGI:MGI:5559905\|PMID:24394384
Cellular Component	GO:0005654	nucleoplasm	METTL14	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	METTL14	IDA		Human	PMID:24316715
Cellular Component	GO:0005634	nucleus	METTL14	IDA		Human	PMID:26458103
Cellular Component	GO:0005634	nucleus	METTL14	IDA		Human	PMID:29348140
Cellular Component	GO:0005634	nucleus	Mettl14	IDA		Mouse	MGI:MGI:6103038\|PMID:28914256
Cellular Component	GO:0005634	nucleus	Mettl14	IDA		Mouse	PMID:24394384
Cellular Component	GO:0036396	RNA N6-methyladenosine methyltransferase complex	METTL14	IPI		Human	PMID:29507755
Cellular Component	GO:0036396	RNA N6-methyladenosine methyltransferase complex	METTL14	IDA		Human	PMID:24316715
Cellular Component	GO:0036396	RNA N6-methyladenosine methyltransferase complex	METTL14	IDA		Human	PMID:24981863
Cellular Component	GO:0036396	RNA N6-methyladenosine methyltransferase complex	METTL14	IDA		Human	PMID:27627798
Cellular Component	GO:0036396	RNA N6-methyladenosine methyltransferase complex	METTL14	IDA		Human	PMID:29348140
Cellular Component	GO:0036396	RNA N6-methyladenosine methyltransferase complex	METTL14	IDA		Human	PMID:29507755
Cellular Component	GO:0036396	RNA N6-methyladenosine methyltransferase complex	Mettl14	IDA		Mouse	MGI:MGI:6158697\|PMID:29547716
Biological Process	GO:0021861	forebrain radial glial cell differentiation	Mettl14	IMP		Mouse	MGI:MGI:5927282\|PMID:28965759
Biological Process	GO:0042063	gliogenesis	Mettl14	IMP		Mouse	MGI:MGI:5927282\|PMID:28965759
Biological Process	GO:0006402	mRNA catabolic process	Mettl14	IMP		Mouse	MGI:MGI:5927282\|PMID:28965759
Biological Process	GO:0061157	mRNA destabilization	Mettl14	IMP		Mouse	MGI:MGI:5559905\|PMID:24394384
Biological Process	GO:0061157	mRNA destabilization	Mettl14	IMP		Mouse	MGI:MGI:5927282\|PMID:28965759
Biological Process	GO:0080009	mRNA methylation	METTL14	IMP		Human	PMID:24316715
Biological Process	GO:0080009	mRNA methylation	METTL14	IMP		Human	PMID:25719671
Biological Process	GO:0080009	mRNA methylation	METTL14	IDA		Human	PMID:27281194
Biological Process	GO:0080009	mRNA methylation	METTL14	IDA		Human	PMID:27373337
Biological Process	GO:0080009	mRNA methylation	METTL14	IDA		Human	PMID:27627798
Biological Process	GO:0080009	mRNA methylation	METTL14	IMP		Human	PMID:29290617
Biological Process	GO:0080009	mRNA methylation	Mettl14	IDA		Mouse	MGI:MGI:5559905\|PMID:24394384
Biological Process	GO:0080009	mRNA methylation	Mettl14	IDA		Mouse	MGI:MGI:5927282\|PMID:28965759
Biological Process	GO:0080009	mRNA methylation	Mettl14	IMP		Mouse	PMID:31340148
Biological Process	GO:0000398	mRNA splicing, via spliceosome	METTL14	IMP		Human	PMID:25719671
Biological Process	GO:1901533	negative regulation of hematopoietic progenitor cell differentiation	METTL14	IMP		Human	PMID:29290617
Biological Process	GO:1901533	negative regulation of hematopoietic progenitor cell differentiation	Mettl14	IMP		Mouse	MGI:MGI:6278085\|PMID:29290617
Biological Process	GO:0045727	positive regulation of translation	METTL14	IMP		Human	PMID:29290617
Biological Process	GO:0045664	regulation of neuron differentiation	Mettl14	IMP		Mouse	MGI:MGI:6390707\|PMID:31340148
Biological Process	GO:0001510	RNA methylation	Mettl14	IMP		Mouse	MGI:MGI:6103038\|PMID:28914256
Biological Process	GO:0007283	spermatogenesis	Mettl14	IMP		Mouse	MGI:MGI:6103038\|PMID:28914256
Biological Process	GO:0019827	stem cell population maintenance	Mettl14	IMP		Mouse	MGI:MGI:5559905\|PMID:24394384

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.