Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MFF
  • Mouse genes Mff
  • Rat genes Mff
  • Zfish genes mffa,mffb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Mff

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0051020	GTPase binding	Mff	IPI	RGD:620416	Rat	PMID:23792689|RGD:12793033
Molecular Function	GO:0051020	GTPase binding	Mff	IPI	UniProtKB:O35303	Rat	PMID:23792689|RGD:12793033
Molecular Function	GO:0042802	identical protein binding	MFF	IPI	UniProtKB:Q9GZY8	Human	PMID:18353969
Molecular Function	GO:0005515	protein binding	MFF	IPI	UniProtKB:O00429	Human	PMID:21149567
Molecular Function	GO:0005515	protein binding	MFF	IPI	UniProtKB:O00429	Human	PMID:26358295
Molecular Function	GO:0005515	protein binding	MFF	IPI	UniProtKB:O00429	Human	PMID:29464060
Molecular Function	GO:0005515	protein binding	Mff	IPI	UniProtKB:Q8K1M6	Mouse	MGI:MGI:6286869|PMID:30914652
Molecular Function	GO:0005515	protein binding	Mff	IPI	UniProtKB:Q8K1M6|UniProtKB:Q9D4W2	Mouse	MGI:MGI:6200588|PMID:30059978
Molecular Function	GO:0005515	protein binding	Mff	IPI	PR:Q8K1M6	Mouse	PMID:21149567
Molecular Function	GO:0005515	protein binding	Mff	IPI	UniProtKB:P21707	Rat	PMID:23792689|RGD:12793033
Molecular Function	GO:0005515	protein binding	Mff	IPI	UniProtKB:P53563	Rat	PMID:23792689|RGD:12793033
Molecular Function	GO:0042803	protein homodimerization activity	MFF	IDA		Human	PMID:23530241
Molecular Function	GO:0044877	protein-containing complex binding	Mff	IPI	RGD:2200|RGD:620416|RGD:70919	Rat	PMID:23792689|RGD:12793033
Cellular Component	GO:0031966	mitochondrial membrane	MFF	IDA		Human	PMID:18353969
Cellular Component	GO:0031966	mitochondrial membrane	Mff	IMP		Rat	PMID:23792689|RGD:12793033
Cellular Component	GO:0005741	mitochondrial outer membrane	MFF	IDA		Human	PMID:21149567
Cellular Component	GO:0005741	mitochondrial outer membrane	Mff	IDA		Mouse	MGI:MGI:6200588|PMID:30059978
Cellular Component	GO:0005741	mitochondrial outer membrane	Mff	IDA		Mouse	PMID:21149567
Cellular Component	GO:0005739	mitochondrion	MFF	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005739	mitochondrion	Mff	IDA		Mouse	MGI:MGI:4881394|PMID:20451243
Cellular Component	GO:0005777	peroxisome	MFF	IDA		Human	PMID:18353969
Cellular Component	GO:0005777	peroxisome	MFF	IDA		Human	PMID:23921378
Cellular Component	GO:0005777	peroxisome	Mff	IDA		Mouse	MGI:MGI:4881394|PMID:20451243
Cellular Component	GO:0032991	protein-containing complex	MFF	IDA		Human	PMID:18353969
Cellular Component	GO:0008021	synaptic vesicle	Mff	IDA		Rat	PMID:23792689|RGD:12793033
Cellular Component	GO:0030672	synaptic vesicle membrane	Mff	IMP		Rat	PMID:23792689|RGD:12793033
Biological Process	GO:0070301	cellular response to hydrogen peroxide	Mff	IEP		Rat	PMID:23867156|RGD:12879458
Biological Process	GO:0000266	mitochondrial fission	Mff	IDA		Mouse	MGI:MGI:6200588|PMID:30059978
Biological Process	GO:0000266	mitochondrial fission	Mff	IMP		Mouse	MGI:MGI:5508698|PMID:23283981
Biological Process	GO:0043653	mitochondrial fragmentation involved in apoptotic process	MFF	IMP		Human	PMID:18353969
Biological Process	GO:0043653	mitochondrial fragmentation involved in apoptotic process	MFF	IMP		Human	PMID:21149567
Biological Process	GO:0008053	mitochondrial fusion	MFF	IMP		Human	PMID:23921378
Biological Process	GO:0070584	mitochondrion morphogenesis	MFF	IMP		Human	PMID:21149567
Biological Process	GO:0016559	peroxisome fission	MFF	IMP		Human	PMID:18353969
Biological Process	GO:0016559	peroxisome fission	MFF	IMP		Human	PMID:21149567
Biological Process	GO:0010666	positive regulation of cardiac muscle cell apoptotic process	Mff	IMP		Rat	PMID:23867156|RGD:12879458
Biological Process	GO:0090141	positive regulation of mitochondrial fission	MFF	IDA		Human	PMID:23283981
Biological Process	GO:0090141	positive regulation of mitochondrial fission	MFF	IDA		Human	PMID:23530241
Biological Process	GO:0090141	positive regulation of mitochondrial fission	Mff	IMP		Rat	PMID:23867156|RGD:12879458
Biological Process	GO:0090314	positive regulation of protein targeting to membrane	MFF	IDA		Human	PMID:23283981
Biological Process	GO:0090200	positive regulation of release of cytochrome c from mitochondria	MFF	IMP		Human	PMID:21149567
Biological Process	GO:1900244	positive regulation of synaptic vesicle endocytosis	Mff	IMP		Rat	PMID:23792689|RGD:12793033
Biological Process	GO:0006626	protein targeting to mitochondrion	MFF	IMP		Human	PMID:21149567
Biological Process	GO:0006626	protein targeting to mitochondrion	Mff	IDA		Mouse	MGI:MGI:6200588|PMID:30059978
Biological Process	GO:0006626	protein targeting to mitochondrion	Mff	IMP		Rat	PMID:23792689|RGD:12793033
Biological Process	GO:0010821	regulation of mitochondrion organization	MFF	IMP		Human	PMID:18353969
Biological Process	GO:0010821	regulation of mitochondrion organization	MFF	IMP		Human	PMID:21149567
Biological Process	GO:1900063	regulation of peroxisome organization	MFF	IMP		Human	PMID:18353969
Biological Process	GO:0001836	release of cytochrome c from mitochondria	MFF	IMP		Human	PMID:18353969

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern