Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MFGE8
  • Mouse genes Mfge8
  • Rat genes Mfge8
  • Zfish genes mfge8a,mfge8b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Mfge8

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005178	integrin binding	Mfge8	IDA		Mouse	MGI:MGI:5285150|PMID:20826760
Molecular Function	GO:0001786	phosphatidylserine binding	MFGE8	IPI	CHEBI:18303	Human	PMID:21196491
Cellular Component	GO:0062023	collagen-containing extracellular matrix	MFGE8	HDA		Human	PMID:20551380
Cellular Component	GO:0062023	collagen-containing extracellular matrix	MFGE8	HDA		Human	PMID:27068509
Cellular Component	GO:0062023	collagen-containing extracellular matrix	MFGE8	HDA		Human	PMID:27559042
Cellular Component	GO:0062023	collagen-containing extracellular matrix	MFGE8	HDA		Human	PMID:28327460
Cellular Component	GO:0062023	collagen-containing extracellular matrix	Mfge8	HDA		Mouse	MGI:MGI:6201834|PMID:22159717
Cellular Component	GO:0009897	external side of plasma membrane	Mfge8	IDA		Mouse	PMID:12000961
Cellular Component	GO:0070062	extracellular exosome	MFGE8	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	MFGE8	HDA		Human	PMID:19199708
Cellular Component	GO:0070062	extracellular exosome	MFGE8	HDA		Human	PMID:20458337
Cellular Component	GO:0070062	extracellular exosome	MFGE8	HDA		Human	PMID:21362503
Cellular Component	GO:0005615	extracellular space	MFGE8	HDA		Human	PMID:16502470
Cellular Component	GO:0005615	extracellular space	Mfge8	HDA		Mouse	MGI:MGI:5640941|PMID:24006456
Cellular Component	GO:0005615	extracellular space	Mfge8	IDA		Mouse	PMID:12000961
Cellular Component	GO:1903561	extracellular vesicle	MFGE8	HDA		Human	PMID:24769233
Cellular Component	GO:0016020	membrane	MFGE8	HDA		Human	PMID:19946888
Biological Process	GO:0043277	apoptotic cell clearance	Mfge8	IDA		Mouse	MGI:MGI:5285150|PMID:20826760
Biological Process	GO:0008284	positive regulation of cell population proliferation	Mfge8	IEP		Rat	PMID:11085522|RGD:1582499
Biological Process	GO:0043627	response to estrogen	Mfge8	IEP		Rat	PMID:12801995|RGD:1582500

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern