Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Mfn1

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes MFN1
- Mouse genes Mfn1
- Rat genes Mfn1
- Zfish genes mfn1b
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Mfn1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003924	GTPase activity	MFN1	IDA		Human	PMID:27920125
Molecular Function	GO:0003924	GTPase activity	MFN1	IMP		Human	PMID:28114303
Molecular Function	GO:0042802	identical protein binding	MFN1	IPI	UniProtKB:Q8IWA4	Human	PMID:29483649
Molecular Function	GO:0042802	identical protein binding	Mfn1	IPI	RGD:621460	Rat	PMID:14561718\|RGD:1304446
Molecular Function	GO:0005515	protein binding	MFN1	IPI	UniProtKB:O95140	Human	PMID:19052620
Molecular Function	GO:0005515	protein binding	MFN1	IPI	UniProtKB:Q7Z434	Human	PMID:20019757
Molecular Function	GO:0005515	protein binding	MFN1	IPI	UniProtKB:Q9NWX6	Human	PMID:25008184
Molecular Function	GO:0005515	protein binding	MFN1	IPI	UniProtKB:O95140	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	Mfn1	IPI	UniProtKB:Q5S007	Mouse	MGI:MGI:5538411\|PMID:24282027
Molecular Function	GO:0005515	protein binding	Mfn1	IPI	UniProtKB:Q3UN04	Mouse	MGI:MGI:5574552\|PMID:24513856
Molecular Function	GO:0005515	protein binding	Mfn1	IPI	PR:Q64373	Mouse	PMID:20671748
Molecular Function	GO:0005515	protein binding	Mfn1	IPI	PR:Q80U63	Mouse	PMID:12527753
Molecular Function	GO:0005515	protein binding	Mfn1	IPI	PR:Q811U4	Mouse	PMID:12527753
Molecular Function	GO:0005515	protein binding	Mfn1	IPI	PR:Q07813	Mouse	PMID:20671748
Cellular Component	GO:0016020	membrane	MFN1	IDA		Human	PMID:27920125
Cellular Component	GO:0005743	mitochondrial inner membrane	Mfn1	IDA		Rat	PMID:27801955\|RGD:12738369
Cellular Component	GO:0005741	mitochondrial outer membrane	MFN1	IDA		Human	PMID:12759376
Cellular Component	GO:0005741	mitochondrial outer membrane	Mfn1	IDA		Rat	PMID:27801955\|RGD:12738369
Cellular Component	GO:0005739	mitochondrion	MFN1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005739	mitochondrion	MFN1	IDA		Human	PMID:20871098
Cellular Component	GO:0005739	mitochondrion	MFN1	IDA		Human	PMID:27920125
Cellular Component	GO:0005739	mitochondrion	Mfn1	HDA		Mouse	PMID:18614015
Cellular Component	GO:0098799	outer mitochondrial membrane protein complex	MFN1	IDA		Human	PMID:12759376
Biological Process	GO:0071549	cellular response to dexamethasone stimulus	Mfn1	IEP		Rat	PMID:22703557\|RGD:13204845
Biological Process	GO:0071333	cellular response to glucose stimulus	Mfn1	IEP		Rat	PMID:28518143\|RGD:12910712
Biological Process	GO:0071456	cellular response to hypoxia	Mfn1	IEP		Rat	PMID:27833818\|RGD:12910766
Biological Process	GO:0090650	cellular response to oxygen-glucose deprivation	Mfn1	IEP		Rat	PMID:23658809\|RGD:12738215
Biological Process	GO:0046039	GTP metabolic process	MFN1	IDA		Human	PMID:27920125
Biological Process	GO:0048312	intracellular distribution of mitochondria	Mfn1	IMP		Rat	PMID:19605646\|RGD:7800727
Biological Process	GO:0008584	male gonad development	Mfn1	IEP		Rat	PMID:14592431\|RGD:13204840
Biological Process	GO:0008053	mitochondrial fusion	MFN1	IMP		Human	PMID:12759376
Biological Process	GO:0008053	mitochondrial fusion	MFN1	IDA		Human	PMID:20436456
Biological Process	GO:0008053	mitochondrial fusion	MFN1	IMP		Human	PMID:23921378
Biological Process	GO:0008053	mitochondrial fusion	MFN1	IMP		Human	PMID:27920125
Biological Process	GO:0008053	mitochondrial fusion	MFN1	IMP		Human	PMID:28114303
Biological Process	GO:0008053	mitochondrial fusion	Mfn1	IMP		Mouse	MGI:MGI:5574552\|PMID:24513856
Biological Process	GO:0008053	mitochondrial fusion	Mfn1	IGI	UniProtKB:Q80U63	Mouse	MGI:MGI:6377920\|PMID:15899901
Biological Process	GO:0008053	mitochondrial fusion	Mfn1	IMP		Mouse	MGI:MGI:6377920\|PMID:15899901
Biological Process	GO:0008053	mitochondrial fusion	Mfn1	IMP	MGI:MGI:2450304	Mouse	PMID:12527753
Biological Process	GO:0051646	mitochondrion localization	MFN1	IMP		Human	PMID:12759376
Biological Process	GO:0070584	mitochondrion morphogenesis	Mfn1	IMP		Rat	PMID:19605646\|RGD:7800727
Biological Process	GO:0090258	negative regulation of mitochondrial fission	Mfn1	IMP		Rat	PMID:18832378\|RGD:12738368
Biological Process	GO:0061003	positive regulation of dendritic spine morphogenesis	Mfn1	IMP		Rat	PMID:19605646\|RGD:7800727
Biological Process	GO:0010636	positive regulation of mitochondrial fusion	Mfn1	IMP		Rat	PMID:24751540\|RGD:13204834
Biological Process	GO:0010918	positive regulation of mitochondrial membrane potential	Mfn1	IGI	UniProtKB:Q80U63	Mouse	MGI:MGI:6377920\|PMID:15899901
Biological Process	GO:0051592	response to calcium ion	Mfn1	IEP		Rat	PMID:25308841\|RGD:13204805
Biological Process	GO:0051412	response to corticosterone	Mfn1	IEP		Rat	PMID:22244747\|RGD:13204844
Biological Process	GO:0051602	response to electrical stimulus	Mfn1	IEP		Rat	PMID:26513006\|RGD:12910850
Biological Process	GO:0045471	response to ethanol	Mfn1	IEP		Rat	PMID:24751540\|RGD:13204834
Biological Process	GO:1905395	response to flavonoid	Mfn1	IEP		Rat	PMID:24637344\|RGD:12738213
Biological Process	GO:1902617	response to fluoride	Mfn1	IEP		Rat	PMID:24958380\|RGD:12437081
Biological Process	GO:1990910	response to hypobaric hypoxia	Mfn1	IEP		Rat	PMID:24637344\|RGD:12738213
Biological Process	GO:0010042	response to manganese ion	Mfn1	IEP		Rat	PMID:15589972\|RGD:13204841
Biological Process	GO:0014850	response to muscle activity	Mfn1	IEP		Rat	PMID:19716857\|RGD:12738233
Biological Process	GO:0014850	response to muscle activity	Mfn1	IEP		Rat	PMID:22573103\|RGD:12738231
Biological Process	GO:0031667	response to nutrient levels	Mfn1	IEP		Rat	PMID:25336449\|RGD:12880438

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.