Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MFN2
  • Mouse genes Mfn2
  • Rat genes Mfn2
  • Zfish genes mfn2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Mfn2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005525	GTP binding	Mfn2	IMP		Rat	PMID:15322553|RGD:1304351
Molecular Function	GO:0051020	GTPase binding	Mfn2	IDA		Rat	PMID:14561718|RGD:1304446
Molecular Function	GO:0051020	GTPase binding	Mfn2	IPI	UniProtKB:P50904	Rat	PMID:15322553|RGD:1304351
Molecular Function	GO:0042802	identical protein binding	Mfn2	IPI	RGD:628843	Rat	PMID:14561718|RGD:1304446
Molecular Function	GO:0005515	protein binding	MFN2	IPI	UniProtKB:Q9NX47	Human	PMID:16936636
Molecular Function	GO:0005515	protein binding	MFN2	IPI	UniProtKB:Q9UJZ1	Human	PMID:17121834
Molecular Function	GO:0005515	protein binding	MFN2	IPI	UniProtKB:Q8IWA4	Human	PMID:19052620
Molecular Function	GO:0005515	protein binding	MFN2	IPI	UniProtKB:O60260	Human	PMID:23620051
Molecular Function	GO:0005515	protein binding	MFN2	IPI	UniProtKB:Q5S007	Human	PMID:24282027
Molecular Function	GO:0005515	protein binding	MFN2	IPI	UniProtKB:Q9NWX6	Human	PMID:25008184
Molecular Function	GO:0005515	protein binding	MFN2	IPI	UniProtKB:Q9Y512	Human	PMID:27059175
Molecular Function	GO:0005515	protein binding	MFN2	IPI	UniProtKB:Q8IWA4	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	MFN2	IPI	UniProtKB:Q9NX47	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	Mfn2	IPI	UniProtKB:O08734|UniProtKB:Q16611	Mouse	MGI:MGI:3716029|PMID:17606912
Molecular Function	GO:0005515	protein binding	Mfn2	IPI	UniProtKB:O08734	Mouse	MGI:MGI:4834987|PMID:19168699
Molecular Function	GO:0005515	protein binding	Mfn2	IPI	UniProtKB:Q9Z2B5	Mouse	MGI:MGI:5506952|PMID:23921556
Molecular Function	GO:0005515	protein binding	Mfn2	IPI	UniProtKB:Q3UN04	Mouse	MGI:MGI:5574552|PMID:24513856
Molecular Function	GO:0005515	protein binding	Mfn2	IPI	PR:Q64373	Mouse	PMID:20671748
Molecular Function	GO:0005515	protein binding	Mfn2	IPI	PR:Q80U63	Mouse	PMID:12527753
Molecular Function	GO:0005515	protein binding	Mfn2	IPI	PR:Q811U4	Mouse	PMID:12527753
Molecular Function	GO:0005515	protein binding	Mfn2	IPI	PR:Q07813	Mouse	PMID:20671748
Molecular Function	GO:0043394	proteoglycan binding	Mfn2	IPI	RGD:2067	Rat	PMID:25151458|RGD:13204806
Molecular Function	GO:0031267	small GTPase binding	Mfn2	IDA		Rat	PMID:27997345|RGD:12910740
Molecular Function	GO:0031625	ubiquitin protein ligase binding	MFN2	IPI	UniProtKB:Q9NX47	Human	PMID:16936636
Cellular Component	GO:0005737	cytoplasm	Mfn2	IDA		Rat	PMID:28404953|RGD:12910735
Cellular Component	GO:0005829	cytosol	Mfn2	IDA		Rat	PMID:11950885|RGD:8554543
Cellular Component	GO:0015630	microtubule cytoskeleton	Mfn2	IDA		Mouse	PMID:16083859
Cellular Component	GO:0005741	mitochondrial outer membrane	Mfn2	IDA		Rat	PMID:11950885|RGD:8554543
Cellular Component	GO:0005741	mitochondrial outer membrane	Mfn2	IDA		Rat	PMID:14561718|RGD:1304446
Cellular Component	GO:0005739	mitochondrion	MFN2	IDA		Human	PMID:11181170
Cellular Component	GO:0005739	mitochondrion	MFN2	IDA		Human	PMID:20871098
Cellular Component	GO:0005739	mitochondrion	Mfn2	IDA		Mouse	PMID:20671748
Cellular Component	GO:0005739	mitochondrion	Mfn2	HDA		Mouse	PMID:18614015
Cellular Component	GO:0005739	mitochondrion	Mfn2	IDA		Mouse	PMID:17035996
Cellular Component	GO:0005739	mitochondrion	Mfn2	IDA		Rat	PMID:12598526|RGD:1601412
Biological Process	GO:0019896	axonal transport of mitochondrion	mfn2	IMP	ZFIN:ZDB-GENO-100528-33	Zfish	PMID:23840650
Biological Process	GO:0007409	axonogenesis	mfn2	IMP	ZFIN:ZDB-MRPHLNO-110106-1	Zfish	PMID:20951042
Biological Process	GO:0001825	blastocyst formation	Mfn2	IMP		Mouse	PMID:16083859
Biological Process	GO:0048593	camera-type eye morphogenesis	Mfn2	IMP	MGI:MGI:1861626	Mouse	PMID:16104381
Biological Process	GO:0071549	cellular response to dexamethasone stimulus	Mfn2	IEP		Rat	PMID:22703557|RGD:13204845
Biological Process	GO:0071333	cellular response to glucose stimulus	Mfn2	IEP		Rat	PMID:28518143|RGD:12910712
Biological Process	GO:0071456	cellular response to hypoxia	Mfn2	IEP		Rat	PMID:28478070|RGD:12910733
Biological Process	GO:0071479	cellular response to ionizing radiation	Mfn2	IEP		Rat	PMID:26415228|RGD:13204741
Biological Process	GO:1905232	cellular response to L-glutamate	Mfn2	IEP		Rat	PMID:25416777|RGD:13204765
Biological Process	GO:0071404	cellular response to low-density lipoprotein particle stimulus	Mfn2	IEP		Rat	PMID:26062420|RGD:13204747
Biological Process	GO:0071287	cellular response to manganese ion	Mfn2	IEP		Rat	PMID:28232070|RGD:12910738
Biological Process	GO:0072705	cellular response to mercaptoethanol	Mfn2	IEP		Rat	PMID:26903301|RGD:12910838
Biological Process	GO:0090650	cellular response to oxygen-glucose deprivation	Mfn2	IEP		Rat	PMID:23658809|RGD:12738215
Biological Process	GO:0071394	cellular response to testosterone stimulus	Mfn2	IEP		Rat	PMID:26062420|RGD:13204747
Biological Process	GO:0030097	hemopoiesis	mfn2	IMP	ZFIN:ZDB-MRPHLNO-141013-25	Zfish	PMID:25010335
Biological Process	GO:0048312	intracellular distribution of mitochondria	Mfn2	IMP		Rat	PMID:19605646|RGD:7800727
Biological Process	GO:0008584	male gonad development	Mfn2	IEP		Rat	PMID:14592431|RGD:13204840
Biological Process	GO:0051560	mitochondrial calcium ion homeostasis	Mfn2	IMP		Rat	PMID:25147362|RGD:13204807
Biological Process	GO:0008053	mitochondrial fusion	MFN2	IMP		Human	PMID:23921378
Biological Process	GO:0008053	mitochondrial fusion	Mfn2	IMP		Mouse	MGI:MGI:6377920|PMID:15899901
Biological Process	GO:0008053	mitochondrial fusion	Mfn2	IMP		Mouse	MGI:MGI:5574552|PMID:24513856
Biological Process	GO:0008053	mitochondrial fusion	Mfn2	IGI	UniProtKB:Q811U4	Mouse	MGI:MGI:6377920|PMID:15899901
Biological Process	GO:0008053	mitochondrial fusion	Mfn2	IMP	MGI:MGI:2450306	Mouse	PMID:12527753
Biological Process	GO:0008053	mitochondrial fusion	Mfn2	IMP		Mouse	PMID:22493254
Biological Process	GO:0008053	mitochondrial fusion	Mfn2	IMP		Rat	PMID:14561718|RGD:1304446
Biological Process	GO:0007006	mitochondrial membrane organization	MFN2	IDA		Human	PMID:11181170
Biological Process	GO:0051646	mitochondrion localization	MFN2	IDA		Human	PMID:11181170
Biological Process	GO:0070584	mitochondrion morphogenesis	Mfn2	IMP		Rat	PMID:19605646|RGD:7800727
Biological Process	GO:0007005	mitochondrion organization	Mfn2	IMP		Rat	PMID:18006463|RGD:12738362
Biological Process	GO:0000278	mitotic cell cycle	Mfn2	IEP		Rat	PMID:25926139|RGD:11056460
Biological Process	GO:0010667	negative regulation of cardiac muscle cell apoptotic process	Mfn2	IMP		Rat	PMID:28483668|RGD:12910717
Biological Process	GO:0045786	negative regulation of cell cycle	Mfn2	IMP		Rat	PMID:25017825|RGD:13204822
Biological Process	GO:0008285	negative regulation of cell population proliferation	Mfn2	IMP		Rat	PMID:15322553|RGD:1304351
Biological Process	GO:0008285	negative regulation of cell population proliferation	Mfn2	IMP		Rat	PMID:26485208|RGD:12910856
Biological Process	GO:0045792	negative regulation of cell size	Mfn2	IMP		Rat	PMID:27565029|RGD:12910768
Biological Process	GO:0060253	negative regulation of glial cell proliferation	Mfn2	IMP		Rat	PMID:25017825|RGD:13204822
Biological Process	GO:0090258	negative regulation of mitochondrial fission	Mfn2	IMP		Rat	PMID:28478070|RGD:12910733
Biological Process	GO:1901215	negative regulation of neuron death	Mfn2	IMP		Rat	PMID:25147362|RGD:13204807
Biological Process	GO:0046580	negative regulation of Ras protein signal transduction	MFN2	IDA		Human	PMID:15322553
Biological Process	GO:1903427	negative regulation of reactive oxygen species biosynthetic process	Mfn2	IMP		Rat	PMID:28483668|RGD:12910717
Biological Process	GO:0090201	negative regulation of release of cytochrome c from mitochondria	Mfn2	IMP		Rat	PMID:18006463|RGD:12738362
Biological Process	GO:0060299	negative regulation of sarcomere organization	Mfn2	IMP		Rat	PMID:24777478|RGD:13204833
Biological Process	GO:0048662	negative regulation of smooth muscle cell proliferation	Mfn2	IDA		Rat	PMID:15322553|RGD:1304351
Biological Process	GO:1904706	negative regulation of vascular associated smooth muscle cell proliferation	Mfn2	IMP		Rat	PMID:28478070|RGD:12910733
Biological Process	GO:0007528	neuromuscular junction development	mfn2	IMP	ZFIN:ZDB-MRPHLNO-110106-1	Zfish	PMID:20951042
Biological Process	GO:0061734	parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization	Mfn2	IMP		Mouse	MGI:MGI:5498413|PMID:23620051
Biological Process	GO:1901857	positive regulation of cellular respiration	Mfn2	IMP		Rat	PMID:25147362|RGD:13204807
Biological Process	GO:0035563	positive regulation of chromatin binding	Mfn2	IMP		Rat	PMID:27997345|RGD:12910740
Biological Process	GO:0120162	positive regulation of cold-induced thermogenesis	Mfn2	IMP		Mouse	MGI:MGI:5909151|PMID:28539390
Biological Process	GO:0061003	positive regulation of dendritic spine morphogenesis	Mfn2	IMP		Rat	PMID:19605646|RGD:7800727
Biological Process	GO:2000866	positive regulation of estradiol secretion	Mfn2	IMP		Rat	PMID:25120590|RGD:13204819
Biological Process	GO:0010628	positive regulation of gene expression	Mfn2	IMP		Rat	PMID:27997345|RGD:12910740
Biological Process	GO:0046326	positive regulation of glucose import	Mfn2	IMP		Rat	PMID:25034891|RGD:13204821
Biological Process	GO:0010729	positive regulation of hydrogen peroxide biosynthetic process	Mfn2	IMP		Rat	PMID:27997345|RGD:12910740
Biological Process	GO:0046628	positive regulation of insulin receptor signaling pathway	Mfn2	IMP		Rat	PMID:25034891|RGD:13204821
Biological Process	GO:0010918	positive regulation of mitochondrial membrane potential	Mfn2	IMP		Rat	PMID:18006463|RGD:12738362
Biological Process	GO:2000386	positive regulation of ovarian follicle development	Mfn2	IMP		Rat	PMID:25120590|RGD:13204819
Biological Process	GO:2000872	positive regulation of progesterone secretion	Mfn2	IMP		Rat	PMID:25120590|RGD:13204819
Biological Process	GO:1903428	positive regulation of reactive oxygen species biosynthetic process	Mfn2	IMP		Rat	PMID:27997345|RGD:12910740
Biological Process	GO:1905461	positive regulation of vascular associated smooth muscle cell apoptotic process	MFN2	IMP		Human	PMID:27640178
Biological Process	GO:1904707	positive regulation of vascular associated smooth muscle cell proliferation	MFN2	IMP		Human	PMID:27640178
Biological Process	GO:0034497	protein localization to phagophore assembly site	MFN2	IDA		Human	PMID:23455425
Biological Process	GO:0006626	protein targeting to mitochondrion	MFN2	IDA		Human	PMID:11181170
Biological Process	GO:0048678	response to axon injury	Mfn2	IEP		Rat	PMID:23220115|RGD:12738219
Biological Process	GO:0046686	response to cadmium ion	Mfn2	IEP		Rat	PMID:25388156|RGD:13204797
Biological Process	GO:0051592	response to calcium ion	Mfn2	IEP		Rat	PMID:25308841|RGD:13204805
Biological Process	GO:1905377	response to D-galactose	Mfn2	IEP		Rat	PMID:28302704|RGD:12910737
Biological Process	GO:0051602	response to electrical stimulus	Mfn2	IEP		Rat	PMID:26513006|RGD:12910850
Biological Process	GO:0070542	response to fatty acid	Mfn2	IEP		Rat	PMID:25034891|RGD:13204821
Biological Process	GO:1905395	response to flavonoid	Mfn2	IEP		Rat	PMID:24637344|RGD:12738213
Biological Process	GO:1990910	response to hypobaric hypoxia	Mfn2	IEP		Rat	PMID:24637344|RGD:12738213
Biological Process	GO:1903576	response to L-arginine	Mfn2	IEP		Rat	PMID:28483572|RGD:12910731
Biological Process	GO:0014850	response to muscle activity	Mfn2	IEP		Rat	PMID:19716857|RGD:12738233
Biological Process	GO:0031667	response to nutrient levels	Mfn2	IEP		Rat	PMID:25336449|RGD:12880438
Biological Process	GO:0033574	response to testosterone	Mfn2	IEP		Rat	PMID:25770118|RGD:13204749
Biological Process	GO:0007283	spermatogenesis	Mfn2	IEP		Rat	PMID:14592431|RGD:13204840

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern