Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MGA
  • Mouse genes Mga
  • Rat genes Mga
  • Zfish genes mgaa
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Mga

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Mga	IDA		Mouse	MGI:MGI:1351065|PMID:10601024
Molecular Function	GO:0140678	molecular function inhibitor activity	mgaa	IPI	ZFIN:ZDB-GENE-050522-301	Zfish	PMID:30324105
Molecular Function	GO:0005515	protein binding	MGA	IPI	UniProtKB:P61244	Human	PMID:20936779
Molecular Function	GO:0005515	protein binding	MGA	IPI	UniProtKB:Q13185	Human	PMID:20936779
Molecular Function	GO:0005515	protein binding	MGA	IPI	UniProtKB:P61244	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	MGA	IPI	UniProtKB:P61244	Human	PMID:24981860
Molecular Function	GO:0005515	protein binding	MGA	IPI	UniProtKB:Q13185	Human	PMID:24981860
Molecular Function	GO:0005515	protein binding	MGA	IPI	UniProtKB:P61244	Human	PMID:25609649
Molecular Function	GO:0005515	protein binding	MGA	IPI	UniProtKB:P61244	Human	PMID:27705803
Molecular Function	GO:0005515	protein binding	MGA	IPI	UniProtKB:Q13185	Human	PMID:27705803
Molecular Function	GO:0005515	protein binding	MGA	IPI	UniProtKB:Q93009	Human	PMID:35044719
Molecular Function	GO:0005515	protein binding	mgaa	IPI	ZFIN:ZDB-GENE-050522-301	Zfish	PMID:30324105
Molecular Function	GO:0005515	protein binding	mgaa	IPI	ZFIN:ZDB-GENE-990415-152,ZFIN:ZDB-GENE-990603-8	Zfish	PMID:24525188
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	Mga	IDA		Mouse	MGI:MGI:1351065|PMID:10601024
Molecular Function	GO:0000976	transcription cis-regulatory region binding	mgaa	IDA		Zfish	PMID:24525188
Cellular Component	GO:0071339	MLL1 complex	MGA	IDA		Human	PMID:15960975
Cellular Component	GO:0071141	SMAD protein complex	mgaa	IPI	ZFIN:ZDB-GENE-990415-152,ZFIN:ZDB-GENE-990603-8	Zfish	PMID:24525188
Cellular Component	GO:0005667	transcription regulator complex	Mga	IDA		Mouse	PMID:10601024
Biological Process	GO:0048854	brain morphogenesis	mgaa	IMP	ZFIN:ZDB-MRPHLNO-100426-1	Zfish	PMID:20044811
Biological Process	GO:1990830	cellular response to leukemia inhibitory factor	Mga	IEP		Mouse	PMID:20439489
Biological Process	GO:0048264	determination of ventral identity	mgaa	IMP	ZFIN:ZDB-MRPHLNO-140701-4	Zfish	PMID:24525188
Biological Process	GO:0048264	determination of ventral identity	mgaa	IGI	ZFIN:ZDB-MRPHLNO-110607-1,ZFIN:ZDB-MRPHLNO-140701-1,ZFIN:ZDB-MRPHLNO-140701-4	Zfish	PMID:24525188
Biological Process	GO:0048565	digestive tract development	mgaa	IMP	ZFIN:ZDB-MRPHLNO-100426-1	Zfish	PMID:20044811
Biological Process	GO:0001947	heart looping	mgaa	IGI	ZFIN:ZDB-MRPHLNO-051128-1,ZFIN:ZDB-MRPHLNO-100426-1	Zfish	PMID:20044811
Biological Process	GO:0001889	liver development	mgaa	IMP	ZFIN:ZDB-MRPHLNO-100426-1	Zfish	PMID:20044811
Biological Process	GO:0031016	pancreas development	mgaa	IMP	ZFIN:ZDB-MRPHLNO-100426-1	Zfish	PMID:20044811
Biological Process	GO:0060389	pathway-restricted SMAD protein phosphorylation	mgaa	IDA		Zfish	PMID:30324105
Biological Process	GO:0060389	pathway-restricted SMAD protein phosphorylation	mgaa	IMP	ZFIN:ZDB-GENO-200218-18	Zfish	PMID:30324105
Biological Process	GO:0060389	pathway-restricted SMAD protein phosphorylation	mgaa	IMP	ZFIN:ZDB-GENO-200218-17	Zfish	PMID:30324105
Biological Process	GO:0060389	pathway-restricted SMAD protein phosphorylation	mgaa	IMP	ZFIN:ZDB-GENO-200218-16	Zfish	PMID:30324105
Biological Process	GO:0030513	positive regulation of BMP signaling pathway	mgaa	IMP	ZFIN:ZDB-MRPHLNO-140701-4	Zfish	PMID:24525188
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Mga	IDA		Mouse	MGI:MGI:1351065|PMID:10601024

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern