Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MICU2
  • Mouse genes Micu2
  • Rat genes Micu2
  • Zfish genes micu2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Micu2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005509	calcium ion binding	Micu2	IMP		Mouse	MGI:MGI:5558955|PMID:24560927
Molecular Function	GO:0005515	protein binding	MICU2	IPI	UniProtKB:Q9BPX6	Human	PMID:24560927
Molecular Function	GO:0005515	protein binding	MICU2	IPI	UniProtKB:Q9BPX6	Human	PMID:26387864
Molecular Function	GO:0005515	protein binding	MICU2	IPI	UniProtKB:Q9BPX6	Human	PMID:32494073
Molecular Function	GO:0005515	protein binding	Micu2	IPI	UniProtKB:Q8VCX5	Mouse	MGI:MGI:5558955|PMID:24560927
Molecular Function	GO:0046982	protein heterodimerization activity	MICU2	IPI	UniProtKB:Q9BPX6	Human	PMID:24560927
Molecular Function	GO:0046982	protein heterodimerization activity	MICU2	IPI	UniProtKB:Q9BPX6	Human	PMID:26387864
Molecular Function	GO:0046982	protein heterodimerization activity	Micu2	IPI	UniProtKB:Q8VCX5	Mouse	MGI:MGI:5558955|PMID:24560927
Cellular Component	GO:0034704	calcium channel complex	Micu2	IDA		Mouse	MGI:MGI:5487704|PMID:23409044
Cellular Component	GO:0005743	mitochondrial inner membrane	MICU2	IDA		Human	PMID:27099988
Cellular Component	GO:0005758	mitochondrial intermembrane space	MICU2	IDA		Human	PMID:22925203
Cellular Component	GO:0005758	mitochondrial intermembrane space	MICU2	IDA		Human	PMID:24231807
Cellular Component	GO:0005758	mitochondrial intermembrane space	MICU2	IDA		Human	PMID:24560927
Cellular Component	GO:0005739	mitochondrion	Micu2	IMP		Mouse	MGI:MGI:5487704|PMID:23409044
Cellular Component	GO:0005739	mitochondrion	Micu2	HDA		Mouse	PMID:18614015
Cellular Component	GO:1990246	uniplex complex	MICU2	IPI		Human	PMID:32494073
Cellular Component	GO:1990246	uniplex complex	MICU2	IDA		Human	PMID:22925203
Cellular Component	GO:1990246	uniplex complex	MICU2	IDA		Human	PMID:24231807
Cellular Component	GO:1990246	uniplex complex	MICU2	IDA		Human	PMID:24560927
Biological Process	GO:0036444	calcium import into the mitochondrion	MICU2	IMP		Human	PMID:26903221
Biological Process	GO:0036444	calcium import into the mitochondrion	MICU2	IDA		Human	PMID:32494073
Biological Process	GO:0051560	mitochondrial calcium ion homeostasis	MICU2	IMP		Human	PMID:26903221
Biological Process	GO:0051560	mitochondrial calcium ion homeostasis	MICU2	IDA		Human	PMID:32494073
Biological Process	GO:0006851	mitochondrial calcium ion transmembrane transport	MICU2	IDA		Human	PMID:24560927
Biological Process	GO:0006851	mitochondrial calcium ion transmembrane transport	Micu2	IMP		Mouse	MGI:MGI:5487704|PMID:23409044
Biological Process	GO:0051562	negative regulation of mitochondrial calcium ion concentration	MICU2	IDA		Human	PMID:24560927
Biological Process	GO:0051561	positive regulation of mitochondrial calcium ion concentration	Micu2	IMP		Mouse	MGI:MGI:5487704|PMID:23409044

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern