Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MIF
  • Mouse genes Mif
  • Rat genes LOC120102174,LOC679748,Mif,RGD1559921
  • Zfish genes mif
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Mif

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042056	chemoattractant activity	MIF	IDA		Human	PMID:19602265
Molecular Function	GO:0005125	cytokine activity	MIF	IDA		Human	PMID:12782713
Molecular Function	GO:0005125	cytokine activity	Mif	IDA		Mouse	MGI:MGI:4437204|PMID:10364264
Molecular Function	GO:0005125	cytokine activity	Mif	IDA		Mouse	MGI:MGI:3690285|PMID:17045821
Molecular Function	GO:0005126	cytokine receptor binding	MIF	IPI	UniProtKB:P04233	Human	PMID:17045821
Molecular Function	GO:0005126	cytokine receptor binding	MIF	IDA		Human	PMID:21817065
Molecular Function	GO:0004167	dopachrome isomerase activity	MIF	IDA		Human	PMID:17526494
Molecular Function	GO:0042802	identical protein binding	MIF	IPI	UniProtKB:P14174	Human	PMID:20534506
Molecular Function	GO:0042802	identical protein binding	MIF	IPI	UniProtKB:P14174	Human	PMID:25416956
Molecular Function	GO:0042802	identical protein binding	MIF	IPI	UniProtKB:P14174	Human	PMID:31515488
Molecular Function	GO:0042802	identical protein binding	MIF	IPI	UniProtKB:P14174	Human	PMID:32296183
Molecular Function	GO:0050178	phenylpyruvate tautomerase activity	MIF	IDA		Human	PMID:16285950
Molecular Function	GO:0050178	phenylpyruvate tautomerase activity	MIF	IDA		Human	PMID:21817065
Molecular Function	GO:0050178	phenylpyruvate tautomerase activity	Mif	IMP	MGI:MGI:2176337	Mouse	PMID:16285950
Molecular Function	GO:0002020	protease binding	Mif	IPI	UniProtKB:O35864	Mouse	MGI:MGI:5286754|PMID:21817065
Molecular Function	GO:0005515	protein binding	MIF	IPI	UniProtKB:Q7Z465	Human	PMID:12681488
Molecular Function	GO:0005515	protein binding	MIF	IPI	UniProtKB:P14174	Human	PMID:17526494
Molecular Function	GO:0005515	protein binding	MIF	IPI	UniProtKB:O43521-2	Human	PMID:18677096
Molecular Function	GO:0005515	protein binding	MIF	IPI	UniProtKB:Q96HA8	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	MIF	IPI	UniProtKB:P00533	Human	PMID:26280537
Molecular Function	GO:0005515	protein binding	MIF	IPI	UniProtKB:Q92743	Human	PMID:28726057
Molecular Function	GO:0005515	protein binding	MIF	IPI	UniProtKB:Q96HA8	Human	PMID:31515488
Molecular Function	GO:0044877	protein-containing complex binding	Mif	IDA		Rat	PMID:15947686|RGD:1641988
Cellular Component	GO:0009986	cell surface	MIF	IDA		Human	PMID:12782713
Cellular Component	GO:0005737	cytoplasm	MIF	IDA		Human	PMID:24569872
Cellular Component	GO:0005737	cytoplasm	Mif	IDA		Rat	PMID:11126199|RGD:1642009
Cellular Component	GO:0005829	cytosol	MIF	IDA		Human	GO_REF:0000052
Cellular Component	GO:0070062	extracellular exosome	MIF	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	MIF	HDA		Human	PMID:20458337
Cellular Component	GO:0070062	extracellular exosome	MIF	HDA		Human	PMID:23533145
Cellular Component	GO:0005576	extracellular region	MIF	IDA		Human	PMID:12782713
Cellular Component	GO:0005576	extracellular region	MIF	HDA		Human	PMID:27068509
Cellular Component	GO:0005615	extracellular space	MIF	IDA		Human	PMID:21817065
Cellular Component	GO:0005615	extracellular space	Mif	IDA		Mouse	MGI:MGI:5286754|PMID:21817065
Cellular Component	GO:0005615	extracellular space	Mif	IDA		Mouse	MGI:MGI:2156302|PMID:11756671
Cellular Component	GO:0005615	extracellular space	Mif	HDA		Mouse	MGI:MGI:5640941|PMID:24006456
Cellular Component	GO:0005615	extracellular space	Mif	IDA		Rat	PMID:15947686|RGD:1641988
Cellular Component	GO:0043209	myelin sheath	Mif	HDA		Mouse	MGI:MGI:3834050|PMID:17634366
Cellular Component	GO:0005654	nucleoplasm	MIF	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	Mif	IDA		Rat	PMID:15145447|RGD:1641996
Cellular Component	GO:0005886	plasma membrane	MIF	IDA		Human	PMID:24569872
Cellular Component	GO:0031982	vesicle	MIF	HDA		Human	PMID:19190083
Biological Process	GO:0007568	aging	Mif	IEP		Rat	PMID:15856362|RGD:1641992
Biological Process	GO:0060117	auditory receptor cell development	mif	IMP	ZFIN:ZDB-MRPHLNO-120323-3	Zfish	PMID:28928022
Biological Process	GO:0007420	brain development	Mif	IEP		Rat	PMID:9878869|RGD:1642021
Biological Process	GO:0002035	brain renin-angiotensin system	Mif	IMP		Rat	PMID:17261648|RGD:1641980
Biological Process	GO:0019752	carboxylic acid metabolic process	MIF	IDA		Human	PMID:12782713
Biological Process	GO:0008283	cell population proliferation	mif	IMP	ZFIN:ZDB-MRPHLNO-080708-6	Zfish	PMID:18068224
Biological Process	GO:0007166	cell surface receptor signaling pathway	MIF	IDA		Human	PMID:12782713
Biological Process	GO:0070301	cellular response to hydrogen peroxide	Mif	IEP		Rat	PMID:19799867|RGD:4890974
Biological Process	GO:0071456	cellular response to hypoxia	Mif	IEP		Rat	PMID:19462902|RGD:4890975
Biological Process	GO:0090398	cellular senescence	Mif	IMP	MGI:MGI:2673280	Mouse	PMID:12878730
Biological Process	GO:0030330	DNA damage response, signal transduction by p53 class mediator	Mif	IMP	MGI:MGI:2673280	Mouse	PMID:12878730
Biological Process	GO:0042756	drinking behavior	Mif	IMP		Rat	PMID:16809436|RGD:1641982
Biological Process	GO:0048598	embryonic morphogenesis	mif	IMP	ZFIN:ZDB-MRPHLNO-080708-4	Zfish	PMID:18068224
Biological Process	GO:0048598	embryonic morphogenesis	mif	IMP	ZFIN:ZDB-MRPHLNO-080708-6	Zfish	PMID:18068224
Biological Process	GO:0048598	embryonic morphogenesis	mif	IMP	ZFIN:ZDB-MRPHLNO-080708-5	Zfish	PMID:18068224
Biological Process	GO:0001942	hair follicle development	Mif	IEP		Rat	PMID:16232303|RGD:1641987
Biological Process	GO:0048839	inner ear development	mif	IGI	ZFIN:ZDB-MRPHLNO-120323-3,ZFIN:ZDB-MRPHLNO-120323-4,ZFIN:ZDB-MRPHLNO-120323-5	Zfish	PMID:22210003
Biological Process	GO:0043066	negative regulation of apoptotic process	MIF	IDA		Human	PMID:12782713
Biological Process	GO:0043066	negative regulation of apoptotic process	Mif	IDA		Mouse	MGI:MGI:3690285|PMID:17045821
Biological Process	GO:0043066	negative regulation of apoptotic process	mif	IGI	ZFIN:ZDB-MRPHLNO-120323-3,ZFIN:ZDB-MRPHLNO-120323-4,ZFIN:ZDB-MRPHLNO-120323-5	Zfish	PMID:22210003
Biological Process	GO:0030336	negative regulation of cell migration	MIF	IMP		Human	PMID:22952837
Biological Process	GO:2000773	negative regulation of cellular senescence	MIF	IDA		Human	PMID:10562313
Biological Process	GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator	MIF	IDA		Human	PMID:17045821
Biological Process	GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator	Mif	IDA		Mouse	MGI:MGI:3690285|PMID:17045821
Biological Process	GO:0010629	negative regulation of gene expression	MIF	IDA		Human	PMID:10562313
Biological Process	GO:1902166	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	MIF	IDA		Human	PMID:17045821
Biological Process	GO:0010760	negative regulation of macrophage chemotaxis	MIF	IDA		Human	PMID:21817065
Biological Process	GO:0002906	negative regulation of mature B cell apoptotic process	Mif	IDA		Mouse	MGI:MGI:3773489|PMID:18056708
Biological Process	GO:0033033	negative regulation of myeloid cell apoptotic process	Mif	IMP		Mouse	MGI:MGI:2156302|PMID:11756671
Biological Process	GO:0051248	negative regulation of protein metabolic process	Mif	IDA		Mouse	MGI:MGI:2156302|PMID:11756671
Biological Process	GO:0002675	positive regulation of acute inflammatory response	Mif	IMP		Rat	PMID:16455830|RGD:1641985
Biological Process	GO:0090238	positive regulation of arachidonic acid secretion	Mif	IDA		Mouse	MGI:MGI:4437204|PMID:10364264
Biological Process	GO:0048680	positive regulation of axon regeneration	Mif	IMP		Rat	PMID:12456989|RGD:1642004
Biological Process	GO:0030890	positive regulation of B cell proliferation	MIF	IDA		Human	PMID:12782713
Biological Process	GO:0008284	positive regulation of cell population proliferation	MIF	IDA		Human	PMID:10562313
Biological Process	GO:2000343	positive regulation of chemokine (C-X-C motif) ligand 2 production	Mif	IDA		Mouse	MGI:MGI:3773489|PMID:18056708
Biological Process	GO:0001819	positive regulation of cytokine production	MIF	IDA		Human	PMID:19602265
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	MIF	IDA		Human	PMID:12782713
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	MIF	IDA		Human	PMID:17045821
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	MIF	IGI	UniProtKB:P30046	Human	PMID:21817065
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	Mif	IDA		Mouse	MGI:MGI:4437204|PMID:10364264
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	Mif	IDA		Mouse	MGI:MGI:3690285|PMID:17045821
Biological Process	GO:0048146	positive regulation of fibroblast proliferation	MIF	IDA		Human	PMID:12782713
Biological Process	GO:0048146	positive regulation of fibroblast proliferation	Mif	IDA		Mouse	MGI:MGI:4437204|PMID:10364264
Biological Process	GO:0046326	positive regulation of glucose import	Mif	IMP		Rat	PMID:11086030|RGD:1642010
Biological Process	GO:0045821	positive regulation of glycolytic process	Mif	IMP		Rat	PMID:11086030|RGD:1642010
Biological Process	GO:0050778	positive regulation of immune response	Mif	IMP		Rat	PMID:10617911|RGD:1642013
Biological Process	GO:0031666	positive regulation of lipopolysaccharide-mediated signaling pathway	Mif	IMP		Mouse	MGI:MGI:2156302|PMID:11756671
Biological Process	GO:0043406	positive regulation of MAP kinase activity	Mif	IDA		Mouse	MGI:MGI:4437204|PMID:10364264
Biological Process	GO:0061081	positive regulation of myeloid leukocyte cytokine production involved in immune response	Mif	IMP		Mouse	MGI:MGI:2156302|PMID:11756671
Biological Process	GO:0033138	positive regulation of peptidyl-serine phosphorylation	MIF	IDA		Human	PMID:17045821
Biological Process	GO:0033138	positive regulation of peptidyl-serine phosphorylation	Mif	IDA		Mouse	MGI:MGI:3690285|PMID:17045821
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	MIF	IDA		Human	PMID:17045821
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	Mif	IDA		Mouse	MGI:MGI:3690285|PMID:17045821
Biological Process	GO:0042327	positive regulation of phosphorylation	MIF	IDA		Human	PMID:12782713
Biological Process	GO:0043268	positive regulation of potassium ion transport	Mif	IMP		Rat	PMID:16267117|RGD:1641986
Biological Process	GO:0061078	positive regulation of prostaglandin secretion involved in immune response	Mif	IMP		Mouse	MGI:MGI:2156302|PMID:11756671
Biological Process	GO:0010739	positive regulation of protein kinase A signaling	MIF	IDA		Human	PMID:17045821
Biological Process	GO:0001934	positive regulation of protein phosphorylation	Mif	IDA		Mouse	MGI:MGI:4437204|PMID:10364264
Biological Process	GO:0014911	positive regulation of smooth muscle cell migration	Mif	IMP		Rat	PMID:18270460|RGD:4890978
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	MIF	IDA		Human	PMID:21817065
Biological Process	GO:0001516	prostaglandin biosynthetic process	MIF	IDA		Human	PMID:12782713
Biological Process	GO:0070207	protein homotrimerization	MIF	IPI	UniProtKB:P14174	Human	PMID:17526494
Biological Process	GO:0042127	regulation of cell population proliferation	Mif	IMP	MGI:MGI:2673280	Mouse	PMID:12878730
Biological Process	GO:0032355	response to estradiol	Mif	IEP		Rat	PMID:17324399|RGD:1641979
Biological Process	GO:0051384	response to glucocorticoid	Mif	IEP		Rat	PMID:17565848|RGD:1641978
Biological Process	GO:0009408	response to heat	Mif	IEP		Rat	PMID:14625478|RGD:1642001
Biological Process	GO:0009725	response to hormone	Mif	IEP		Rat	PMID:15196698|RGD:1641994
Biological Process	GO:0010035	response to inorganic substance	Mif	IEP		Rat	PMID:17028300|RGD:1641981
Biological Process	GO:0032868	response to insulin	Mif	IEP		Rat	PMID:12435855|RGD:1642005
Biological Process	GO:0032496	response to lipopolysaccharide	Mif	IEP		Rat	PMID:14980085|RGD:1641998
Biological Process	GO:0009612	response to mechanical stimulus	Mif	IEP		Rat	PMID:15886670|RGD:1641990
Biological Process	GO:0032572	response to menaquinone	Mif	IEP		Rat	PMID:15856362|RGD:1641992
Biological Process	GO:0032570	response to progesterone	Mif	IEP		Rat	PMID:17324399|RGD:1641979
Biological Process	GO:0033197	response to vitamin E	Mif	IEP		Rat	PMID:10609875|RGD:1642014
Biological Process	GO:0009410	response to xenobiotic stimulus	Mif	IEP		Rat	PMID:16571782|RGD:1641984
Biological Process	GO:0043588	skin development	Mif	IEP		Rat	PMID:16232303|RGD:1641987
Biological Process	GO:0007283	spermatogenesis	Mif	IMP		Rat	PMID:15169922|RGD:1641995
Biological Process	GO:0042060	wound healing	Mif	IEP		Rat	PMID:14767776|RGD:1641999

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern