Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MICA,MICB
  • Mouse genes Mill2
  • Rat genes Micb
  • Zfish genes mhc1lda,mhc1lea,mhc1lfa
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Mill2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0046703	natural killer cell lectin-like receptor binding	MICB	IDA		Human	PMID:11491531
Molecular Function	GO:0046703	natural killer cell lectin-like receptor binding	MICA	IPI	UniProtKB:P26718	Human	PMID:10426993
Molecular Function	GO:0046703	natural killer cell lectin-like receptor binding	MICA	IDA		Human	PMID:11491531
Molecular Function	GO:0005515	protein binding	MICA	IPI	UniProtKB:P26718	Human	PMID:11323699
Molecular Function	GO:0005515	protein binding	MICA	IPI	UniProtKB:P17931	Human	PMID:21712812
Molecular Function	GO:0005515	protein binding	MICA	IPI	UniProtKB:P26718	Human	PMID:21712812
Molecular Function	GO:0005515	protein binding	Mill2	IPI	PR:P01887	Mouse	PMID:16920948
Cellular Component	GO:0009986	cell surface	MICA	IDA		Human	PMID:18676862
Cellular Component	GO:0009986	cell surface	MICA	IDA		Human	PMID:8901601
Cellular Component	GO:0009897	external side of plasma membrane	Mill2	IDA		Mouse	PMID:16920948
Cellular Component	GO:0005615	extracellular space	MICA	IDA		Human	PMID:18676862
Cellular Component	GO:0005886	plasma membrane	MICA	IDA		Human	PMID:18676862
Biological Process	GO:0042742	defense response to bacterium	MICA	IDA		Human	PMID:11485740
Biological Process	GO:0042742	defense response to bacterium	MICA	IDA		Human	PMID:11830641
Biological Process	GO:0051607	defense response to virus	MICA	IDA		Human	PMID:11224526
Biological Process	GO:0051607	defense response to virus	MICA	IDA		Human	PMID:16750166
Biological Process	GO:0006974	DNA damage response	MICA	IDA		Human	PMID:15995699
Biological Process	GO:0046629	gamma-delta T cell activation	MICB	IDA		Human	PMID:9497295
Biological Process	GO:0046629	gamma-delta T cell activation	MICA	IDA		Human	PMID:9497295
Biological Process	GO:0002418	immune response to tumor cell	MICA	IDA		Human	PMID:10359807
Biological Process	GO:0002429	immune response-activating cell surface receptor signaling pathway	MICB	IDA		Human	PMID:11491531
Biological Process	GO:0042267	natural killer cell mediated cytotoxicity	MICA	IDA		Human	PMID:10426993
Biological Process	GO:0050689	negative regulation of defense response to virus by host	MICB	IDA		Human	PMID:11239445
Biological Process	GO:0050689	negative regulation of defense response to virus by host	MICB	IDA		Human	PMID:12782710
Biological Process	GO:0032815	negative regulation of natural killer cell activation	MICA	IDA		Human	PMID:20068167
Biological Process	GO:0045953	negative regulation of natural killer cell mediated cytotoxicity	MICA	IMP		Human	PMID:20068167
Biological Process	GO:0009408	response to heat	MICB	IDA		Human	PMID:9497295
Biological Process	GO:0009408	response to heat	MICA	IDA		Human	PMID:8901601
Biological Process	GO:0006979	response to oxidative stress	MICB	IDA		Human	PMID:11287116
Biological Process	GO:0032526	response to retinoic acid	MICB	IDA		Human	PMID:12569559
Biological Process	GO:0001913	T cell mediated cytotoxicity	MICA	IDA		Human	PMID:10426993

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern