Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MKLN1
  • Mouse genes Mkln1
  • Rat genes Mkln1
  • Zfish genes mkln1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Mkln1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042802	identical protein binding	MKLN1	IPI	UniProtKB:Q9UL63	Human	PMID:32296183
Molecular Function	GO:0042802	identical protein binding	Mkln1	IPI	UniProtKB:O89050	Mouse	MGI:MGI:5926673|PMID:25579817
Molecular Function	GO:0005515	protein binding	MKLN1	IPI	UniProtKB:Q8N680	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MKLN1	IPI	UniProtKB:Q9BWK5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Mkln1	IPI	UniProtKB:Q96S59	Mouse	MGI:MGI:3806927|PMID:18710924
Molecular Function	GO:0005515	protein binding	Mkln1	IPI	UniProtKB:Q9UMR3	Mouse	PMID:21586270
Molecular Function	GO:0042803	protein homodimerization activity	Mkln1	IDA		Rat	PMID:25579817|RGD:13702173
Cellular Component	GO:0005938	cell cortex	Mkln1	IDA		Mouse	MGI:MGI:1351271|PMID:9724633
Cellular Component	GO:0005737	cytoplasm	MKLN1	IDA		Human	PMID:17467196
Cellular Component	GO:0005737	cytoplasm	Mkln1	IDA		Mouse	PMID:21586270
Cellular Component	GO:0005829	cytosol	Mkln1	IDA		Mouse	MGI:MGI:3806927|PMID:18710924
Cellular Component	GO:0005829	cytosol	Mkln1	IDA		Mouse	MGI:MGI:1351271|PMID:9724633
Cellular Component	GO:0005829	cytosol	Mkln1	IDA		Rat	PMID:25579817|RGD:13702173
Cellular Component	GO:0005654	nucleoplasm	Mkln1	IDA		Mouse	MGI:MGI:3806927|PMID:18710924
Cellular Component	GO:0001726	ruffle	Mkln1	IDA		Mouse	MGI:MGI:1351271|PMID:9724633
Cellular Component	GO:0000151	ubiquitin ligase complex	MKLN1	IDA		Human	PMID:29911972
Biological Process	GO:0031532	actin cytoskeleton reorganization	Mkln1	IMP		Mouse	MGI:MGI:3806927|PMID:18710924
Biological Process	GO:0031532	actin cytoskeleton reorganization	Mkln1	IMP		Mouse	MGI:MGI:1351271|PMID:9724633
Biological Process	GO:0007160	cell-matrix adhesion	Mkln1	IMP		Mouse	MGI:MGI:1351271|PMID:9724633
Biological Process	GO:0008360	regulation of cell shape	Mkln1	IMP		Mouse	MGI:MGI:1351271|PMID:9724633
Biological Process	GO:0008360	regulation of cell shape	Mkln1	IMP		Mouse	MGI:MGI:3806927|PMID:18710924
Biological Process	GO:0002090	regulation of receptor internalization	Mkln1	IMP		Rat	PMID:25579817|RGD:13702173

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern