Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MKNK2
  • Mouse genes Mknk2
  • Rat genes Mknk2
  • Zfish genes mknk2a,mknk2b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Mknk2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005524	ATP binding	MKNK2	IDA		Human	PMID:11463832
Molecular Function	GO:0005524	ATP binding	Mknk2	IDA		Mouse	MGI:MGI:87363|PMID:9155017
Molecular Function	GO:0005515	protein binding	MKNK2	IPI	UniProtKB:Q16539	Human	PMID:20936779
Molecular Function	GO:0005515	protein binding	MKNK2	IPI	UniProtKB:Q16539	Human	PMID:23602568
Molecular Function	GO:0005515	protein binding	MKNK2	IPI	UniProtKB:Q16539	Human	PMID:25241761
Molecular Function	GO:0005515	protein binding	MKNK2	IPI	UniProtKB:Q16539	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	Mknk2	IPI	UniProtKB:P39429|UniProtKB:P63085	Mouse	MGI:MGI:3688344|PMID:15102471
Molecular Function	GO:0004674	protein serine/threonine kinase activity	MKNK2	IDA		Human	PMID:11463832
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Mknk2	IDA		Mouse	MGI:MGI:87363|PMID:9155017
Cellular Component	GO:0016604	nuclear body	MKNK2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	MKNK2	IDA		Human	GO_REF:0000052
Biological Process	GO:0071243	cellular response to arsenic-containing substance	MKNK2	IDA		Human	PMID:18299328
Biological Process	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	Mknk2	IGI	MGI:MGI:894316	Mouse	PMID:17903173
Biological Process	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	Mknk2	IMP	MGI:MGI:3052675	Mouse	PMID:17903173
Biological Process	GO:0030097	hemopoiesis	MKNK2	IDA		Human	PMID:21149447
Biological Process	GO:0035556	intracellular signal transduction	MKNK2	IDA		Human	PMID:11463832
Biological Process	GO:0035556	intracellular signal transduction	Mknk2	IDA		Mouse	MGI:MGI:87363|PMID:9155017
Biological Process	GO:0006468	protein phosphorylation	MKNK2	IDA		Human	PMID:11463832
Biological Process	GO:0006468	protein phosphorylation	Mknk2	IDA		Mouse	MGI:MGI:87363|PMID:9155017

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern