Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MLX
  • Mouse genes Mlx
  • Rat genes Mlx
  • Zfish genes mlx
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Mlx

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003677	DNA binding	MLX	IDA		Human	PMID:11230181
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	MLX	IDA		Human	PMID:10918583
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	MLX	IMP		Human	PMID:10918583
Molecular Function	GO:0005515	protein binding	MLX	IPI	UniProtKB:P60520	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	MLX	IPI	UniProtKB:Q2Q067	Human	PMID:22458338
Molecular Function	GO:0005515	protein binding	MLX	IPI	UniProtKB:A0A0C4DGF1	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	MLX	IPI	UniProtKB:P60520	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	MLX	IPI	UniProtKB:Q08117	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	MLX	IPI	UniProtKB:Q14498-3	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	MLX	IPI	UniProtKB:P60520	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	MLX	IPI	UniProtKB:Q08117	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	Mlx	IPI	PR:Q2VPU4	Mouse	PMID:12446771
Molecular Function	GO:0046982	protein heterodimerization activity	MLX	IPI	UniProtKB:Q9NP71	Human	PMID:11230181
Molecular Function	GO:0042803	protein homodimerization activity	MLX	IPI	UniProtKB:Q9UH92	Human	PMID:11230181
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	MLX	IDA		Human	PMID:10918583
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	MLX	IPI	UniProtKB:Q9NP71	Human	PMID:11230181
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	Mlx	IDA		Mouse	PMID:18606808
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	MLX	IDA		Human	PMID:28473536
Molecular Function	GO:0140537	transcription regulator activator activity	Mlx	IDA		Mouse	PMID:18606808
Cellular Component	GO:0005737	cytoplasm	MLX	IDA		Human	PMID:10918583
Cellular Component	GO:0005737	cytoplasm	Mlx	IDA		Mouse	PMID:12446771
Cellular Component	GO:0005829	cytosol	MLX	IDA		Human	GO_REF:0000052
Cellular Component	GO:0031965	nuclear membrane	MLX	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	MLX	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	MLX	IDA		Human	PMID:10918583
Cellular Component	GO:0005634	nucleus	Mlx	IDA		Mouse	PMID:21084751
Cellular Component	GO:0005634	nucleus	Mlx	IDA		Mouse	PMID:18606808
Cellular Component	GO:0005634	nucleus	Mlx	IDA		Mouse	PMID:12446771
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	MLX	IDA		Human	PMID:11230181
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	MLX	IMP		Human	PMID:10918583
Biological Process	GO:0006913	nucleocytoplasmic transport	Mlx	IDA		Mouse	PMID:12446771
Biological Process	GO:0045821	positive regulation of glycolytic process	Mlx	IDA		Mouse	PMID:14742444
Biological Process	GO:0046889	positive regulation of lipid biosynthetic process	Mlx	IDA		Mouse	PMID:14742444
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	MLX	IDA		Human	PMID:11073985
Biological Process	GO:0000432	positive regulation of transcription from RNA polymerase II promoter by glucose	Mlx	IDA		Mouse	PMID:14742444

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern