Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MMACHC
  • Mouse genes Mmachc
  • Rat genes Mmachc
  • Zfish genes mmachc
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Mmachc

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0033787	cyanocobalamin reductase (cyanide-eliminating) activity	MMACHC	IDA		Human	PMID:19700356
Molecular Function	GO:0032451	demethylase activity	MMACHC	IDA		Human	PMID:19801555
Molecular Function	GO:0071949	FAD binding	MMACHC	IDA		Human	PMID:19700356
Molecular Function	GO:0043295	glutathione binding	MMACHC	IDA		Human	PMID:22642810
Molecular Function	GO:0016491	oxidoreductase activity	MMACHC	EXP		Human	PMID:19801555
Molecular Function	GO:0016491	oxidoreductase activity	MMACHC	IDA		Human	PMID:19801555
Molecular Function	GO:0016491	oxidoreductase activity	MMACHC	EXP		Human	PMID:21697092
Molecular Function	GO:0016491	oxidoreductase activity	MMACHC	IDA		Human	PMID:21697092
Molecular Function	GO:0005515	protein binding	MMACHC	IPI	UniProtKB:Q9H3L0	Human	PMID:23415655
Molecular Function	GO:0005515	protein binding	MMACHC	IPI	UniProtKB:Q99707	Human	PMID:23825108
Molecular Function	GO:0005515	protein binding	MMACHC	IPI	UniProtKB:O14678	Human	PMID:25535791
Molecular Function	GO:0005515	protein binding	MMACHC	IPI	UniProtKB:Q9NUN5	Human	PMID:25535791
Molecular Function	GO:0005515	protein binding	MMACHC	IPI	UniProtKB:Q99707	Human	PMID:27771510
Molecular Function	GO:0005515	protein binding	MMACHC	IPI	UniProtKB:Q9H3L0	Human	PMID:27771510
Molecular Function	GO:0005515	protein binding	MMACHC	IPI	UniProtKB:Q9UBK8	Human	PMID:27771510
Molecular Function	GO:0042803	protein homodimerization activity	MMACHC	IPI	UniProtKB:Q9Y4U1	Human	PMID:22642810
Cellular Component	GO:0005737	cytoplasm	MMACHC	IDA		Human	PMID:23270877
Cellular Component	GO:0005829	cytosol	MMACHC	IDA		Human	PMID:23270877
Cellular Component	GO:0005739	mitochondrion	Mmachc	HDA		Mouse	PMID:18614015
Biological Process	GO:0009235	cobalamin metabolic process	MMACHC	IDA		Human	PMID:19700356
Biological Process	GO:0009235	cobalamin metabolic process	MMACHC	IDA		Human	PMID:22642810
Biological Process	GO:0009235	cobalamin metabolic process	MMACHC	IMP		Human	PMID:23825108
Biological Process	GO:0070988	demethylation	MMACHC	IDA		Human	PMID:19801555
Biological Process	GO:0048703	embryonic viscerocranium morphogenesis	mmachc	IMP	ZFIN:ZDB-MRPHLNO-150305-3	Zfish	PMID:25281006
Biological Process	GO:0006749	glutathione metabolic process	MMACHC	IDA		Human	PMID:19801555
Biological Process	GO:0006749	glutathione metabolic process	MMACHC	IDA		Human	PMID:22642810

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern