Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MMP13
  • Mouse genes Mmp13
  • Rat genes Mmp13
  • Zfish genes mmp13a,mmp13b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Mmp13

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005509	calcium ion binding	MMP13	IDA		Human	PMID:23913860
Molecular Function	GO:0005509	calcium ion binding	Mmp13	IDA		Rat	PMID:8910479|RGD:2298541
Molecular Function	GO:0048306	calcium-dependent protein binding	Mmp13	IDA		Rat	PMID:10514495|RGD:2298533
Molecular Function	GO:0005518	collagen binding	MMP13	IDA		Human	PMID:9065415
Molecular Function	GO:0004175	endopeptidase activity	MMP13	IDA		Human	PMID:18164633
Molecular Function	GO:0001968	fibronectin binding	Mmp13	IPI	RGD:2624	Rat	PMID:18039280|RGD:2296060
Molecular Function	GO:0050750	low-density lipoprotein particle receptor binding	Mmp13	IPI	RGD:1307535	Rat	PMID:10514495|RGD:2298533
Molecular Function	GO:0004222	metalloendopeptidase activity	MMP13	IDA		Human	PMID:8576151
Molecular Function	GO:0004222	metalloendopeptidase activity	MMP13	IDA		Human	PMID:9065415
Molecular Function	GO:0004222	metalloendopeptidase activity	Mmp13	IDA		Mouse	PMID:11953314
Molecular Function	GO:0004222	metalloendopeptidase activity	Mmp13	IDA		Mouse	PMID:14702107
Molecular Function	GO:0004222	metalloendopeptidase activity	Mmp13	IDA		Rat	PMID:17941091|RGD:2296055
Molecular Function	GO:0004222	metalloendopeptidase activity	Mmp13	IDA		Rat	PMID:8910479|RGD:2298541
Molecular Function	GO:0008233	peptidase activity	Mmp13	IDA		Mouse	PMID:15581614
Molecular Function	GO:0008270	zinc ion binding	MMP13	IDA		Human	PMID:23913860
Molecular Function	GO:0008270	zinc ion binding	Mmp13	IDA		Rat	PMID:8910479|RGD:2298541
Cellular Component	GO:0005615	extracellular space	Mmp13	IDA		Rat	PMID:17941091|RGD:2296055
Cellular Component	GO:0005794	Golgi apparatus	Mmp13	IDA		Rat	PMID:14751562|RGD:2296059
Cellular Component	GO:0046581	intercellular canaliculus	Mmp13	IDA		Rat	PMID:14751562|RGD:2296059
Cellular Component	GO:0005764	lysosome	Mmp13	IDA		Rat	PMID:14751562|RGD:2296059
Biological Process	GO:0030282	bone mineralization	Mmp13	IMP		Mouse	MGI:MGI:3771509|PMID:17987127
Biological Process	GO:0060349	bone morphogenesis	MMP13	IDA		Human	PMID:16167086
Biological Process	GO:0071498	cellular response to fluid shear stress	Mmp13	IEP		Rat	PMID:21246051|RGD:10043175
Biological Process	GO:0030574	collagen catabolic process	MMP13	IDA		Human	PMID:8576151
Biological Process	GO:0030574	collagen catabolic process	MMP13	IDA		Human	PMID:9065415
Biological Process	GO:0030574	collagen catabolic process	Mmp13	IMP		Mouse	MGI:MGI:3771509|PMID:17987127
Biological Process	GO:0030574	collagen catabolic process	Mmp13	IDA		Mouse	PMID:15563592
Biological Process	GO:0035116	embryonic hindlimb morphogenesis	Mmp13	IEP		Rat	PMID:11850435|RGD:1582550
Biological Process	GO:0001958	endochondral ossification	Mmp13	IMP		Mouse	MGI:MGI:3771509|PMID:17987127
Biological Process	GO:0001958	endochondral ossification	Mmp13	IEP		Rat	PMID:10646117|RGD:10043159
Biological Process	GO:0044849	estrous cycle	Mmp13	IEP		Rat	PMID:8691099|RGD:10043158
Biological Process	GO:0022617	extracellular matrix disassembly	MMP13	IMP		Human	PMID:8576151
Biological Process	GO:0022617	extracellular matrix disassembly	MMP13	IMP		Human	PMID:9065415
Biological Process	GO:0022617	extracellular matrix disassembly	Mmp13	IMP		Mouse	MGI:MGI:3771509|PMID:17987127
Biological Process	GO:0003417	growth plate cartilage development	Mmp13	IGI	MGI:MGI:98729	Mouse	PMID:21444811
Biological Process	GO:0007507	heart development	Mmp13	IDA		Rat	PMID:12061388|RGD:10043157
Biological Process	GO:0001554	luteolysis	Mmp13	IEP		Rat	PMID:10537164|RGD:7207086
Biological Process	GO:0048246	macrophage chemotaxis	mmp13a	IMP	ZFIN:ZDB-MRPHLNO-081231-2	Zfish	PMID:18641354
Biological Process	GO:0001503	ossification	Mmp13	IEP		Rat	PMID:15883642|RGD:1582555
Biological Process	GO:0001649	osteoblast differentiation	Mmp13	IEP		Rat	PMID:10528234|RGD:10043160
Biological Process	GO:0007567	parturition	Mmp13	IEP		Rat	PMID:8691099|RGD:10043158
Biological Process	GO:1904244	positive regulation of pancreatic trypsinogen secretion	Mmp13	IDA		Rat	PMID:12771515|RGD:724699
Biological Process	GO:0030163	protein catabolic process	Mmp13	IDA		Rat	PMID:17941091|RGD:2296055
Biological Process	GO:0019538	protein metabolic process	Mmp13	IDA		Mouse	PMID:11953314
Biological Process	GO:0006508	proteolysis	Mmp13	IMP		Mouse	MGI:MGI:3771509|PMID:17987127
Biological Process	GO:0043627	response to estrogen	Mmp13	IEP		Rat	PMID:15609084|RGD:1540386
Biological Process	GO:0009725	response to hormone	Mmp13	IDA		Rat	PMID:9553127|RGD:1582551
Biological Process	GO:0001666	response to hypoxia	Mmp13	IEP		Rat	PMID:16965566|RGD:1582552
Biological Process	GO:0009612	response to mechanical stimulus	Mmp13	IEP		Rat	PMID:15475197|RGD:1582560
Biological Process	GO:0009410	response to xenobiotic stimulus	Mmp13	IEP		Rat	PMID:23325540|RGD:7207215

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern