Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MMP8
  • Mouse genes Mmp8
  • Rat genes Mmp8
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Mmp8

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005509	calcium ion binding	Mmp8	IMP		Rat	PMID:16153442|RGD:2298554
Molecular Function	GO:0004175	endopeptidase activity	MMP8	IMP		Human	PMID:25049354
Molecular Function	GO:0008237	metallopeptidase activity	Mmp8	IDA		Rat	PMID:16153442|RGD:2298554
Molecular Function	GO:0008233	peptidase activity	MMP8	IDA		Human	PMID:23845380
Molecular Function	GO:0004252	serine-type endopeptidase activity	MMP8	IDA		Human	PMID:16192646
Molecular Function	GO:0004252	serine-type endopeptidase activity	MMP8	IDA		Human	PMID:2164002
Molecular Function	GO:0008270	zinc ion binding	Mmp8	IMP		Rat	PMID:16153442|RGD:2298554
Cellular Component	GO:0062023	collagen-containing extracellular matrix	MMP8	HDA		Human	PMID:28344315
Cellular Component	GO:0005615	extracellular space	MMP8	IDA		Human	PMID:2164002
Cellular Component	GO:0005615	extracellular space	MMP8	IDA		Human	PMID:24784232
Cellular Component	GO:0005615	extracellular space	Mmp8	HDA		Mouse	MGI:MGI:5640941|PMID:24006456
Cellular Component	GO:0005615	extracellular space	Mmp8	IDA		Rat	PMID:16940237|RGD:2298555
Biological Process	GO:0035987	endodermal cell differentiation	MMP8	IEP		Human	PMID:23154389
Biological Process	GO:0010629	negative regulation of gene expression	Mmp8	IMP		Mouse	MGI:MGI:6201889|PMID:25049354
Biological Process	GO:0032693	negative regulation of interleukin-10 production	Mmp8	IMP		Mouse	MGI:MGI:6201889|PMID:25049354
Biological Process	GO:0001503	ossification	Mmp8	IEP		Rat	PMID:15052653|RGD:1540385
Biological Process	GO:0043388	positive regulation of DNA binding	Mmp8	IMP		Mouse	MGI:MGI:6201889|PMID:25049354
Biological Process	GO:0010628	positive regulation of gene expression	Mmp8	IMP		Mouse	MGI:MGI:6201889|PMID:25049354
Biological Process	GO:0032755	positive regulation of interleukin-6 production	Mmp8	IMP		Mouse	MGI:MGI:6201889|PMID:25049354
Biological Process	GO:0046330	positive regulation of JNK cascade	Mmp8	IMP		Mouse	MGI:MGI:6201889|PMID:25049354
Biological Process	GO:0043410	positive regulation of MAPK cascade	Mmp8	IMP		Mouse	MGI:MGI:6201889|PMID:25049354
Biological Process	GO:1903980	positive regulation of microglial cell activation	Mmp8	IMP		Mouse	MGI:MGI:6201889|PMID:25049354
Biological Process	GO:0150078	positive regulation of neuroinflammatory response	Mmp8	IMP		Mouse	MGI:MGI:6201889|PMID:25049354
Biological Process	GO:0150078	positive regulation of neuroinflammatory response	Mmp8	IMP		Rat	PMID:25049354|RGD:13792525
Biological Process	GO:1901224	positive regulation of NIK/NF-kappaB signaling	Mmp8	IMP		Mouse	MGI:MGI:6201889|PMID:25049354
Biological Process	GO:0045429	positive regulation of nitric oxide biosynthetic process	Mmp8	IMP		Mouse	MGI:MGI:6201889|PMID:25049354
Biological Process	GO:0045429	positive regulation of nitric oxide biosynthetic process	Mmp8	IMP		Rat	PMID:25049354|RGD:13792525
Biological Process	GO:1903428	positive regulation of reactive oxygen species biosynthetic process	Mmp8	IMP		Mouse	MGI:MGI:6201889|PMID:25049354
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	Mmp8	IMP		Mouse	MGI:MGI:6201889|PMID:25049354
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	Mmp8	IMP		Rat	PMID:25049354|RGD:13792525
Biological Process	GO:0030163	protein catabolic process	Mmp8	IDA		Rat	PMID:16153442|RGD:2298554
Biological Process	GO:0006508	proteolysis	MMP8	IDA		Human	PMID:2164002

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern