Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Mmp9

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes MMP9
- Mouse genes Mmp9
- Rat genes Mmp9
- Zfish genes mmp9
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Mmp9

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004175	endopeptidase activity	MMP9	EXP		Human	PMID:12062105
Molecular Function	GO:0004175	endopeptidase activity	MMP9	IDA		Human	PMID:19022250
Molecular Function	GO:0004175	endopeptidase activity	MMP9	EXP		Human	PMID:9256427
Molecular Function	GO:0001968	fibronectin binding	Mmp9	IPI	RGD:2624	Rat	PMID:18039280\|RGD:2296060
Molecular Function	GO:0042802	identical protein binding	MMP9	IPI	UniProtKB:P14780	Human	PMID:17937912
Molecular Function	GO:0042802	identical protein binding	MMP9	IPI	UniProtKB:P14780	Human	PMID:18077379
Molecular Function	GO:0042802	identical protein binding	MMP9	IPI	UniProtKB:P14780	Human	PMID:23601700
Molecular Function	GO:0004222	metalloendopeptidase activity	MMP9	IDA		Human	PMID:16192646
Molecular Function	GO:0004222	metalloendopeptidase activity	MMP9	IDA		Human	PMID:24164424
Molecular Function	GO:0004222	metalloendopeptidase activity	MMP9	IDA		Human	PMID:2551898
Molecular Function	GO:0004222	metalloendopeptidase activity	MMP9	IDA		Human	PMID:9789069
Molecular Function	GO:0004222	metalloendopeptidase activity	Mmp9	IDA		Mouse	MGI:MGI:6695674\|PMID:23142597
Molecular Function	GO:0004222	metalloendopeptidase activity	Mmp9	IDA		Mouse	PMID:12419962
Molecular Function	GO:0004222	metalloendopeptidase activity	Mmp9	IDA		Mouse	PMID:9291580
Molecular Function	GO:0004222	metalloendopeptidase activity	Mmp9	IDA		Mouse	PMID:14707083
Molecular Function	GO:0008237	metallopeptidase activity	MMP9	IDA		Human	PMID:24236012
Molecular Function	GO:0008237	metallopeptidase activity	MMP9	IDA		Human	PMID:26514923
Molecular Function	GO:0008237	metallopeptidase activity	Mmp9	IDA		Rat	PMID:11826121\|RGD:70539
Molecular Function	GO:0008233	peptidase activity	MMP9	IDA		Human	PMID:23845380
Molecular Function	GO:0008233	peptidase activity	Mmp9	IDA		Mouse	PMID:15800063
Molecular Function	GO:0008233	peptidase activity	Mmp9	IDA		Rat	PMID:20110414\|RGD:4142798
Molecular Function	GO:0008233	peptidase activity	Mmp9	IDA		Rat	PMID:8531210\|RGD:7207198
Molecular Function	GO:0005515	protein binding	MMP9	IPI	UniProtKB:Q16610	Human	PMID:16512877
Molecular Function	GO:0005515	protein binding	MMP9	IPI	UniProtKB:Q8IX30	Human	PMID:21441952
Molecular Function	GO:0005515	protein binding	MMP9	IPI	UniProtKB:P01033	Human	PMID:2251898
Molecular Function	GO:0005515	protein binding	MMP9	IPI	UniProtKB:Q16819	Human	PMID:23123160
Molecular Function	GO:0005515	protein binding	MMP9	IPI	UniProtKB:Q16820	Human	PMID:23123160
Molecular Function	GO:0005515	protein binding	MMP9	IPI	UniProtKB:P13611	Human	PMID:23601700
Molecular Function	GO:0005515	protein binding	MMP9	IPI	UniProtKB:Q9ZFS6	Human	PMID:29328525
Molecular Function	GO:0005515	protein binding	Mmp9	IPI	RGD:69408	Rat	PMID:17148685\|RGD:2316510
Molecular Function	GO:0044877	protein-containing complex binding	Mmp9	IDA		Rat	PMID:16935996\|RGD:2325938
Molecular Function	GO:0044877	protein-containing complex binding	Mmp9	IDA		Rat	PMID:9732233\|RGD:7207196
Molecular Function	GO:0004252	serine-type endopeptidase activity	MMP9	EXP		Human	PMID:17428795
Cellular Component	GO:0062023	collagen-containing extracellular matrix	MMP9	HDA		Human	PMID:28344315
Cellular Component	GO:0062023	collagen-containing extracellular matrix	Mmp9	HDA		Mouse	MGI:MGI:6201834\|PMID:22159717
Cellular Component	GO:0070062	extracellular exosome	MMP9	HDA		Human	PMID:23533145
Cellular Component	GO:0005576	extracellular region	MMP9	HDA		Human	PMID:27068509
Cellular Component	GO:0005615	extracellular space	MMP9	IDA		Human	PMID:24236012
Cellular Component	GO:0005615	extracellular space	MMP9	IDA		Human	PMID:2551898
Cellular Component	GO:0005615	extracellular space	MMP9	IDA		Human	PMID:25645918
Cellular Component	GO:0005615	extracellular space	Mmp9	IDA		Rat	PMID:17603938\|RGD:1642033
Cellular Component	GO:0032991	protein-containing complex	Mmp9	IDA		Rat	PMID:16935996\|RGD:2325938
Biological Process	GO:0007568	aging	Mmp9	IEP		Rat	PMID:16208432\|RGD:8694091
Biological Process	GO:0007568	aging	Mmp9	IDA		Rat	PMID:23281803\|RGD:13207329
Biological Process	GO:0006915	apoptotic process	Mmp9	IMP	MGI:MGI:1932294	Mouse	PMID:15800063
Biological Process	GO:0016477	cell migration	MMP9	IGI	RNAcentral:URS000029D9F1_9606	Human	PMID:28280358
Biological Process	GO:0071276	cellular response to cadmium ion	MMP9	IDA		Human	PMID:26514923
Biological Process	GO:0071460	cellular response to cell-matrix adhesion	Mmp9	IMP		Rat	PMID:12963432\|RGD:2325968
Biological Process	GO:0071460	cellular response to cell-matrix adhesion	Mmp9	IEP		Rat	PMID:20218972\|RGD:2325787
Biological Process	GO:0071345	cellular response to cytokine stimulus	Mmp9	IEP		Rat	PMID:19909738\|RGD:2325816
Biological Process	GO:0071347	cellular response to interleukin-1	Mmp9	IEP		Rat	PMID:16046515\|RGD:2313720
Biological Process	GO:0071347	cellular response to interleukin-1	Mmp9	IEP		Rat	PMID:20145375\|RGD:2325789
Biological Process	GO:0071283	cellular response to iron(III) ion	Mmp9	IEP		Rat	PMID:21683124\|RGD:7207286
Biological Process	GO:0071222	cellular response to lipopolysaccharide	Mmp9	IEP		Rat	PMID:21683124\|RGD:7207286
Biological Process	GO:0071404	cellular response to low-density lipoprotein particle stimulus	Mmp9	IEP		Rat	PMID:19554388\|RGD:2325827
Biological Process	GO:0034614	cellular response to reactive oxygen species	MMP9	IDA		Human	PMID:26514923
Biological Process	GO:0071356	cellular response to tumor necrosis factor	Mmp9	IEP		Rat	PMID:22410640\|RGD:7207278
Biological Process	GO:0071492	cellular response to UV-A	MMP9	IDA		Human	PMID:31380578
Biological Process	GO:0030574	collagen catabolic process	Mmp9	IDA		Mouse	PMID:9291580
Biological Process	GO:0030574	collagen catabolic process	Mmp9	IDA		Rat	PMID:22410640\|RGD:7207278
Biological Process	GO:0030199	collagen fibril organization	mmp9	IMP	ZFIN:ZDB-MRPHLNO-100504-5	Zfish	PMID:26015541
Biological Process	GO:0030199	collagen fibril organization	mmp9	IGI	ZFIN:ZDB-GENE-040426-2169	Zfish	PMID:26015541
Biological Process	GO:0007566	embryo implantation	Mmp9	IDA		Mouse	PMID:18556655
Biological Process	GO:0035987	endodermal cell differentiation	MMP9	IEP		Human	PMID:23154389
Biological Process	GO:0060429	epithelium development	mmp9	IGI	ZFIN:ZDB-GENE-040426-2169	Zfish	PMID:26015541
Biological Process	GO:0030198	extracellular matrix organization	Mmp9	IGI	MGI:MGI:96778	Mouse	PMID:15800063
Biological Process	GO:0030198	extracellular matrix organization	Mmp9	IMP	MGI:MGI:1932294	Mouse	PMID:15800063
Biological Process	GO:0033334	fin morphogenesis	mmp9	IMP	ZFIN:ZDB-MRPHLNO-140227-4	Zfish	PMID:24278401
Biological Process	GO:0031101	fin regeneration	mmp9	IMP	ZFIN:ZDB-MRPHLNO-100504-5	Zfish	PMID:26015541
Biological Process	GO:0003417	growth plate cartilage development	mmp9	IMP	ZFIN:ZDB-GENO-200109-19	Zfish	PMID:30785394
Biological Process	GO:0007507	heart development	Mmp9	IDA		Rat	PMID:12061388\|RGD:10043157
Biological Process	GO:0035701	hematopoietic stem cell migration	mmp9	IMP	ZFIN:ZDB-MRPHLNO-100504-5	Zfish	PMID:28416284
Biological Process	GO:0035701	hematopoietic stem cell migration	mmp9	IGI	ZFIN:ZDB-GENE-030318-1	Zfish	PMID:28416284
Biological Process	GO:0090594	inflammatory response to wounding	mmp9	IMP	ZFIN:ZDB-MRPHLNO-151013-7	Zfish	PMID:24852213
Biological Process	GO:0001822	kidney development	Mmp9	IEP		Rat	PMID:9733107\|RGD:8547907
Biological Process	GO:0048246	macrophage chemotaxis	Mmp9	IDA		Rat	PMID:20110414\|RGD:4142798
Biological Process	GO:0043066	negative regulation of apoptotic process	MMP9	IMP		Human	PMID:22984561
Biological Process	GO:2001258	negative regulation of cation channel activity	MMP9	IDA		Human	PMID:24164424
Biological Process	GO:2001268	negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway	MMP9	IMP		Human	PMID:22984561
Biological Process	GO:2000697	negative regulation of epithelial cell differentiation involved in kidney development	Mmp9	IDA		Mouse	MGI:MGI:6270954\|PMID:24503540
Biological Process	GO:0048147	negative regulation of fibroblast proliferation	Mmp9	IMP		Rat	PMID:22490164\|RGD:8547905
Biological Process	GO:0060253	negative regulation of glial cell proliferation	mmp9	IMP	ZFIN:ZDB-FISH-210714-2	Zfish	PMID:32034934
Biological Process	GO:2001243	negative regulation of intrinsic apoptotic signaling pathway	MMP9	IMP		Human	PMID:22984561
Biological Process	GO:0001503	ossification	Mmp9	IEP		Rat	PMID:15883642\|RGD:1582555
Biological Process	GO:0007567	parturition	Mmp9	IEP		Rat	PMID:7492685\|RGD:8547908
Biological Process	GO:0045766	positive regulation of angiogenesis	Mmp9	IMP		Rat	PMID:19948826\|RGD:2325814
Biological Process	GO:0043065	positive regulation of apoptotic process	Mmp9	IMP	MGI:MGI:1932294	Mouse	PMID:15800063
Biological Process	GO:0043388	positive regulation of DNA binding	MMP9	IDA		Human	PMID:22984561
Biological Process	GO:0045742	positive regulation of epidermal growth factor receptor signaling pathway	MMP9	IMP		Human	PMID:22984561
Biological Process	GO:0002633	positive regulation of granuloma formation	mmp9	IMP	ZFIN:ZDB-MRPHLNO-100504-4	Zfish	PMID:20007864
Biological Process	GO:0002633	positive regulation of granuloma formation	mmp9	IMP	ZFIN:ZDB-MRPHLNO-100504-3	Zfish	PMID:20007864
Biological Process	GO:0002633	positive regulation of granuloma formation	mmp9	IMP	ZFIN:ZDB-MRPHLNO-100504-5	Zfish	PMID:20007864
Biological Process	GO:0051549	positive regulation of keratinocyte migration	MMP9	IMP		Human	PMID:17704059
Biological Process	GO:0002687	positive regulation of leukocyte migration	Mmp9	IDA		Rat	PMID:16698855\|RGD:8693715
Biological Process	GO:0001934	positive regulation of protein phosphorylation	MMP9	IMP		Human	PMID:22984561
Biological Process	GO:1900122	positive regulation of receptor binding	MMP9	IDA		Human	PMID:24164424
Biological Process	GO:0090200	positive regulation of release of cytochrome c from mitochondria	MMP9	IMP		Human	PMID:22984561
Biological Process	GO:0031915	positive regulation of synaptic plasticity	Mmp9	IMP		Rat	PMID:17493927\|RGD:1642034
Biological Process	GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway	mmp9	IMP	ZFIN:ZDB-MRPHLNO-180830-8	Zfish	PMID:32004993
Biological Process	GO:1904707	positive regulation of vascular associated smooth muscle cell proliferation	MMP9	IMP		Human	PMID:18667463
Biological Process	GO:0030163	protein catabolic process	Mmp9	IDA		Rat	PMID:11788364\|RGD:631244
Biological Process	GO:0030163	protein catabolic process	Mmp9	IDA		Rat	PMID:16303975\|RGD:1580555
Biological Process	GO:0006508	proteolysis	MMP9	IDA		Human	PMID:15863497
Biological Process	GO:0006508	proteolysis	MMP9	IDA		Human	PMID:19022250
Biological Process	GO:0006508	proteolysis	MMP9	IDA		Human	PMID:24164424
Biological Process	GO:0006508	proteolysis	MMP9	IDA		Human	PMID:2551898
Biological Process	GO:0006508	proteolysis	Mmp9	IDA		Rat	PMID:20110414\|RGD:4142798
Biological Process	GO:1904645	response to amyloid-beta	Mmp9	IDA		Mouse	MGI:MGI:6294206\|PMID:28912710
Biological Process	GO:0009617	response to bacterium	mmp9	IMP	ZFIN:ZDB-MRPHLNO-151013-7	Zfish	PMID:24852213
Biological Process	GO:0009617	response to bacterium	mmp9	IDA		Zfish	PMID:15829308
Biological Process	GO:0032355	response to estradiol	Mmp9	IEP		Rat	PMID:19889233\|RGD:2325866
Biological Process	GO:0045471	response to ethanol	Mmp9	IEP		Rat	PMID:17603938\|RGD:1642033
Biological Process	GO:0045471	response to ethanol	Mmp9	IEP		Rat	PMID:20405265\|RGD:2325780
Biological Process	GO:0009408	response to heat	Mmp9	IEP		Rat	PMID:17156757\|RGD:1642051
Biological Process	GO:0009644	response to high light intensity	Mmp9	IEP		Rat	PMID:17854381\|RGD:8547925
Biological Process	GO:0055093	response to hyperoxia	Mmp9	IEP		Rat	PMID:19099751\|RGD:5129684
Biological Process	GO:0001666	response to hypoxia	Mmp9	IEP		Rat	PMID:17289933\|RGD:1642045
Biological Process	GO:0032496	response to lipopolysaccharide	Mmp9	IEP		Rat	PMID:17452115\|RGD:1642037
Biological Process	GO:0009612	response to mechanical stimulus	Mmp9	IEP		Rat	PMID:17158349\|RGD:1642049
Biological Process	GO:0035094	response to nicotine	Mmp9	IEP		Rat	PMID:19879865\|RGD:2325822
Biological Process	GO:0007584	response to nutrient	Mmp9	IEP		Rat	PMID:17650800\|RGD:1642032
Biological Process	GO:0014070	response to organic cyclic compound	Mmp9	IEP		Rat	PMID:17114644\|RGD:1642056
Biological Process	GO:0010033	response to organic substance	Mmp9	IEP		Rat	PMID:17603938\|RGD:1642033
Biological Process	GO:0006979	response to oxidative stress	Mmp9	IDA		Rat	PMID:15642321\|RGD:1582600
Biological Process	GO:0009314	response to radiation	Mmp9	IEP		Rat	PMID:17337891\|RGD:1642044
Biological Process	GO:0009314	response to radiation	Mmp9	IEP		Rat	PMID:20159792\|RGD:2325788
Biological Process	GO:0032526	response to retinoic acid	Mmp9	IEP		Rat	PMID:19099751\|RGD:5129684
Biological Process	GO:0034612	response to tumor necrosis factor	Mmp9	IEP		Rat	PMID:17704356\|RGD:2325928
Biological Process	GO:0033189	response to vitamin A	Mmp9	IEP		Rat	PMID:17164434\|RGD:1642048
Biological Process	GO:0009410	response to xenobiotic stimulus	Mmp9	IDA		Rat	PMID:16846501\|RGD:1582611
Biological Process	GO:0009410	response to xenobiotic stimulus	Mmp9	IEP		Rat	PMID:17603938\|RGD:1642033
Biological Process	GO:0001501	skeletal system development	Mmp9	IMP	MGI:MGI:1932294	Mouse	PMID:15800063
Biological Process	GO:0001501	skeletal system development	Mmp9	IGI	MGI:MGI:96778	Mouse	PMID:15800063
Biological Process	GO:0048771	tissue remodeling	Mmp9	IDA		Rat	PMID:16740171\|RGD:1582597
Biological Process	GO:0042060	wound healing	mmp9	IMP	ZFIN:ZDB-MRPHLNO-100504-5	Zfish	PMID:26015541

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.