Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MPC1
  • Mouse genes Mpc1
  • Rat genes Mpc1
  • Zfish genes mpc1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Mpc1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	MPC1	IPI	UniProtKB:O95563	Human	PMID:32296183
Molecular Function	GO:0050833	pyruvate transmembrane transporter activity	Mpc1	IDA		Mouse	PMID:22628554
Molecular Function	GO:0050833	pyruvate transmembrane transporter activity	Mpc1	IGI	MGI:MGI:1917706	Mouse	PMID:22628554
Cellular Component	GO:0005743	mitochondrial inner membrane	MPC1	IDA		Human	PMID:26253029
Cellular Component	GO:0005743	mitochondrial inner membrane	Mpc1	IDA		Mouse	PMID:22628554
Cellular Component	GO:0005743	mitochondrial inner membrane	Mpc1	HDA		Mouse	PMID:12865426
Cellular Component	GO:0005739	mitochondrion	MPC1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005739	mitochondrion	Mpc1	HDA		Mouse	PMID:18614015
Biological Process	GO:0006086	acetyl-CoA biosynthetic process from pyruvate	Mpc1	IMP		Mouse	PMID:22628558
Biological Process	GO:1990830	cellular response to leukemia inhibitory factor	Mpc1	IEP		Mouse	PMID:20439489
Biological Process	GO:0048565	digestive tract development	mpc1	IMP	ZFIN:ZDB-MRPHLNO-180130-8	Zfish	PMID:28397687
Biological Process	GO:0006850	mitochondrial pyruvate transmembrane transport	MPC1	IDA		Human	PMID:26253029
Biological Process	GO:0006850	mitochondrial pyruvate transmembrane transport	MPC1	IDA		Human	PMID:27317664
Biological Process	GO:0006850	mitochondrial pyruvate transmembrane transport	Mpc1	IGI	MGI:MGI:1917706	Mouse	PMID:22628554
Biological Process	GO:0006090	pyruvate metabolic process	mpc1	IMP	ZFIN:ZDB-MRPHLNO-180130-8	Zfish	PMID:28397687

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern