Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MPL
  • Mouse genes Mpl
  • Rat genes Mpl
  • Zfish genes mpl
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Mpl

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	MPL	IPI	UniProtKB:O60674	Human	PMID:24931576
Molecular Function	GO:0038164	thrombopoietin receptor activity	MPL	IMP		Human	PMID:25538044
Cellular Component	GO:0009986	cell surface	MPL	IDA		Human	PMID:25538044
Cellular Component	GO:0009986	cell surface	Mpl	IDA		Rat	PMID:20467749|RGD:10449021
Cellular Component	GO:0005794	Golgi apparatus	MPL	IDA		Human	PMID:25538044
Cellular Component	GO:0043005	neuron projection	Mpl	IDA		Rat	PMID:15642952|RGD:10449018
Cellular Component	GO:0043025	neuronal cell body	Mpl	IDA		Rat	PMID:15642952|RGD:10449018
Cellular Component	GO:0031965	nuclear membrane	MPL	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	MPL	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	Mpl	IDA		Rat	PMID:20467749|RGD:10449021
Biological Process	GO:1990960	basophil homeostasis	Mpl	IMP		Rat	PMID:10606160|RGD:10449003
Biological Process	GO:0071456	cellular response to hypoxia	Mpl	IEP		Rat	PMID:15642952|RGD:10449018
Biological Process	GO:0060216	definitive hemopoiesis	Mpl	IMP	MGI:MGI:2686901	Mouse	PMID:20711984
Biological Process	GO:1990959	eosinophil homeostasis	Mpl	IMP		Rat	PMID:10606160|RGD:10449003
Biological Process	GO:0048872	homeostasis of number of cells	Mpl	IMP	MGI:MGI:2660811	Mouse	PMID:20643340
Biological Process	GO:0035702	monocyte homeostasis	Mpl	IMP		Rat	PMID:10606160|RGD:10449003
Biological Process	GO:0043066	negative regulation of apoptotic process	Mpl	IMP	MGI:MGI:2686901	Mouse	PMID:20711984
Biological Process	GO:0001780	neutrophil homeostasis	Mpl	IMP		Rat	PMID:10606160|RGD:10449003
Biological Process	GO:0070527	platelet aggregation	Mpl	IEP		Rat	PMID:15670044|RGD:10448997
Biological Process	GO:0030220	platelet formation	Mpl	IGI	MGI:MGI:1276116	Mouse	PMID:18684867
Biological Process	GO:0010628	positive regulation of gene expression	Mpl	IMP	MGI:MGI:2686901	Mouse	PMID:20711984
Biological Process	GO:0050671	positive regulation of lymphocyte proliferation	Mpl	IMP		Rat	PMID:10606160|RGD:10449003
Biological Process	GO:1905221	positive regulation of platelet formation	Mpl	IMP		Rat	PMID:10606160|RGD:10449003
Biological Process	GO:0032642	regulation of chemokine production	Mpl	IMP	MGI:MGI:2660811	Mouse	PMID:20643340
Biological Process	GO:2000035	regulation of stem cell division	Mpl	IMP	MGI:MGI:2686901	Mouse	PMID:20711984
Biological Process	GO:0072091	regulation of stem cell proliferation	Mpl	IMP	MGI:MGI:2686901	Mouse	PMID:20711984
Biological Process	GO:0002574	thrombocyte differentiation	mpl	IMP	ZFIN:ZDB-GENO-170921-2	Zfish	PMID:27811851
Biological Process	GO:0038163	thrombopoietin-mediated signaling pathway	Mpl	IDA		Mouse	MGI:MGI:6158801|PMID:25468569

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern