Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MR1
  • Mouse genes Mr1
  • Rat genes Mr1
  • Zfish genes mhc1lja,mhc1uba,mhc1uka,mhc1ula,mhc1zaa,mhc1zba,mhc1zca,mhc1zea,mhc1zfa,mhc1zja,mhc1zka
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Mr1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0030881	beta-2-microglobulin binding	MR1	IDA		Human	PMID:26795251
Molecular Function	GO:0005515	protein binding	MR1	IPI	UniProtKB:Q969F0	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	MR1	IPI	UniProtKB:P61769	Human	PMID:27043408
Molecular Function	GO:0042608	T cell receptor binding	MR1	IDA		Human	PMID:26795251
Cellular Component	GO:0031901	early endosome membrane	MR1	IDA		Human	PMID:27043408
Cellular Component	GO:0005783	endoplasmic reticulum	MR1	IDA		Human	PMID:21190736
Cellular Component	GO:0005789	endoplasmic reticulum membrane	MR1	IDA		Human	PMID:27043408
Cellular Component	GO:0031902	late endosome membrane	MR1	IDA		Human	PMID:27043408
Cellular Component	GO:0005886	plasma membrane	MR1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	MR1	IDA		Human	PMID:27043408
Biological Process	GO:0019884	antigen processing and presentation of exogenous antigen	MR1	IDA		Human	PMID:27043408
Biological Process	GO:0002367	cytokine production involved in immune response	Mr1	IMP	MGI:MGI:3664578	Mouse	PMID:21190736
Biological Process	GO:0050829	defense response to Gram-negative bacterium	MR1	IDA		Human	PMID:20581831
Biological Process	GO:0050829	defense response to Gram-negative bacterium	Mr1	IMP		Mouse	MGI:MGI:4818706|PMID:20581831
Biological Process	GO:0050829	defense response to Gram-negative bacterium	Mr1	IMP	MGI:MGI:3664578	Mouse	PMID:21190736
Biological Process	GO:0050830	defense response to Gram-positive bacterium	MR1	IDA		Human	PMID:27527800
Biological Process	GO:0032611	interleukin-1 beta production	Mr1	IMP	MGI:MGI:3664578	Mouse	PMID:21190736
Biological Process	GO:0032620	interleukin-17 production	Mr1	IMP	MGI:MGI:3664578	Mouse	PMID:21190736
Biological Process	GO:0002854	positive regulation of T cell mediated cytotoxicity directed against tumor cell target	MR1	IDA		Human	PMID:31959982
Biological Process	GO:0033077	T cell differentiation in thymus	Mr1	IMP		Mouse	MGI:MGI:3664456|PMID:12634786

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern