Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MRAP2
  • Mouse genes Mrap2
  • Rat genes Mrap2
  • Zfish genes mrap2a,mrap2b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Mrap2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0031780	corticotropin hormone receptor binding	MRAP2	IPI	UniProtKB:Q01718	Human	PMID:19329486
Molecular Function	GO:0042802	identical protein binding	MRAP2	IPI	UniProtKB:Q96G30	Human	PMID:19329486
Molecular Function	GO:0042802	identical protein binding	MRAP2	IPI	UniProtKB:Q96G30	Human	PMID:20371771
Molecular Function	GO:0005515	protein binding	MRAP2	IPI	UniProtKB:Q01718	Human	PMID:19329486
Molecular Function	GO:0005515	protein binding	MRAP2	IPI	UniProtKB:Q8TCY5	Human	PMID:19329486
Molecular Function	GO:0005515	protein binding	MRAP2	IPI	UniProtKB:Q8TCY5	Human	PMID:20371771
Molecular Function	GO:0005515	protein binding	MRAP2	IPI	UniProtKB:Q01718	Human	PMID:28298427
Molecular Function	GO:0005515	protein binding	MRAP2	IPI	UniProtKB:O43765	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MRAP2	IPI	UniProtKB:Q6UXK2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MRAP2	IPI	UniProtKB:Q96BI3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MRAP2	IPI	UniProtKB:Q96HE8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MRAP2	IPI	UniProtKB:P23560-2	Human	PMID:32814053
Molecular Function	GO:0030545	signaling receptor regulator activity	Mrap2	IMP		Mouse	MGI:MGI:5502469|PMID:23869016
Molecular Function	GO:0030545	signaling receptor regulator activity	mrap2b	IMP		Zfish	PMID:23869017|ZFIN:ZDB-PUB-130805-10
Molecular Function	GO:0070996	type 1 melanocortin receptor binding	MRAP2	IPI	UniProtKB:Q01726	Human	PMID:19329486
Molecular Function	GO:0031781	type 3 melanocortin receptor binding	MRAP2	IPI	UniProtKB:P41968	Human	PMID:19329486
Molecular Function	GO:0031782	type 4 melanocortin receptor binding	MRAP2	IPI	UniProtKB:P32245	Human	PMID:19329486
Molecular Function	GO:0031782	type 4 melanocortin receptor binding	Mrap2	IDA		Mouse	MGI:MGI:5502469|PMID:23869016
Molecular Function	GO:0031782	type 4 melanocortin receptor binding	mrap2b	IDA		Zfish	PMID:23869017|ZFIN:ZDB-PUB-130805-10
Molecular Function	GO:0031782	type 4 melanocortin receptor binding	mrap2a	IDA		Zfish	PMID:23869017|ZFIN:ZDB-PUB-130805-10
Molecular Function	GO:0031783	type 5 melanocortin receptor binding	MRAP2	IPI	UniProtKB:P33032	Human	PMID:19329486
Cellular Component	GO:0005737	cytoplasm	mrap2b	IDA		Zfish	PMID:20138960
Cellular Component	GO:0005783	endoplasmic reticulum	MRAP2	IDA		Human	PMID:19329486
Cellular Component	GO:0005783	endoplasmic reticulum	mrap2a	IDA		Zfish	PMID:24709359
Cellular Component	GO:0005783	endoplasmic reticulum	mrap2b	IDA		Zfish	PMID:24709359
Cellular Component	GO:0005794	Golgi apparatus	mrap2a	IDA		Zfish	PMID:24709359
Cellular Component	GO:0005794	Golgi apparatus	mrap2b	IDA		Zfish	PMID:24709359
Cellular Component	GO:0048471	perinuclear region of cytoplasm	mrap2b	IDA		Zfish	PMID:20138960
Cellular Component	GO:0005886	plasma membrane	MRAP2	IDA		Human	PMID:19329486
Cellular Component	GO:0005886	plasma membrane	mrap2a	IDA		Zfish	PMID:20138960
Biological Process	GO:0051641	cellular localization	mrap2b	IDA		Zfish	PMID:20138960
Biological Process	GO:0048589	developmental growth	mrap2a	IGI	ZFIN:ZDB-MRPHLNO-130226-1,ZFIN:ZDB-MRPHLNO-130913-2	Zfish	PMID:23869017
Biological Process	GO:0048589	developmental growth	mrap2a	IMP	ZFIN:ZDB-MRPHLNO-130913-3	Zfish	PMID:23869017
Biological Process	GO:0048589	developmental growth	mrap2a	IMP	ZFIN:ZDB-MRPHLNO-130913-2	Zfish	PMID:23869017
Biological Process	GO:0097009	energy homeostasis	Mrap2	IMP		Mouse	MGI:MGI:5502469|PMID:23869016
Biological Process	GO:0097009	energy homeostasis	mrap2a	IMP		Zfish	PMID:23869017|ZFIN:ZDB-PUB-130805-10
Biological Process	GO:0097009	energy homeostasis	mrap2b	IMP		Zfish	PMID:23869017|ZFIN:ZDB-PUB-130805-10
Biological Process	GO:0006112	energy reserve metabolic process	Mrap2	IMP		Mouse	MGI:MGI:5502469|PMID:23869016
Biological Process	GO:0006112	energy reserve metabolic process	mrap2b	IMP		Zfish	PMID:23869017|ZFIN:ZDB-PUB-130805-10
Biological Process	GO:0006112	energy reserve metabolic process	mrap2a	IMP		Zfish	PMID:23869017|ZFIN:ZDB-PUB-130805-10
Biological Process	GO:0007631	feeding behavior	Mrap2	IMP		Mouse	MGI:MGI:5502469|PMID:23869016
Biological Process	GO:0106072	negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	MRAP2	IDA		Human	PMID:19329486
Biological Process	GO:0106072	negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	mrap2a	IMP		Zfish	PMID:23869017
Biological Process	GO:1903077	negative regulation of protein localization to plasma membrane	MRAP2	IDA		Human	PMID:19329486
Biological Process	GO:0106071	positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	MRAP2	IDA		Human	PMID:19329486
Biological Process	GO:0106071	positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	mrap2b	IMP		Zfish	PMID:23869017
Biological Process	GO:0034394	protein localization to cell surface	mrap2a	IDA		Zfish	PMID:20138960
Biological Process	GO:0072659	protein localization to plasma membrane	MRAP2	IDA		Human	PMID:19329486
Biological Process	GO:0040008	regulation of growth	mrap2a	IGI	ZFIN:ZDB-GENO-130226-3,ZFIN:ZDB-MRPHLNO-130913-2	Zfish	PMID:23869017
Biological Process	GO:0040008	regulation of growth	mrap2a	IGI	ZFIN:ZDB-GENO-130226-3,ZFIN:ZDB-MRPHLNO-130913-3	Zfish	PMID:23869017
Biological Process	GO:0042594	response to starvation	mrap2b	IDA		Zfish	PMID:24709359

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern