Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MRE11
  • Mouse genes Mre11a
  • Rat genes Mre11
  • Zfish genes mre11a
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Mre11a

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008408	3'-5' exonuclease activity	MRE11	IDA		Human	PMID:9651580
Molecular Function	GO:0008408	3'-5' exonuclease activity	MRE11	IDA		Human	PMID:9705271
Molecular Function	GO:0008409	5'-3' exonuclease activity	MRE11	IDA		Human	PMID:29670289
Molecular Function	GO:0045296	cadherin binding	MRE11	HDA		Human	PMID:25468996
Molecular Function	GO:0003677	DNA binding	MRE11	IDA		Human	PMID:15790808
Molecular Function	GO:0004520	DNA endonuclease activity	MRE11	IDA		Human	PMID:9705271
Molecular Function	GO:0003678	DNA helicase activity	MRE11	IMP		Human	PMID:15790808
Molecular Function	GO:0042802	identical protein binding	MRE11	IPI	UniProtKB:P49959	Human	PMID:22078559
Molecular Function	GO:0005515	protein binding	MRE11	IPI	UniProtKB:O60934	Human	PMID:12419185
Molecular Function	GO:0005515	protein binding	MRE11	IPI	UniProtKB:P16104	Human	PMID:12419185
Molecular Function	GO:0005515	protein binding	MRE11	IPI	UniProtKB:P15336	Human	PMID:15916964
Molecular Function	GO:0005515	protein binding	MRE11	IPI	UniProtKB:P16104	Human	PMID:16377563
Molecular Function	GO:0005515	protein binding	MRE11	IPI	UniProtKB:P03243-1	Human	PMID:17428914
Molecular Function	GO:0005515	protein binding	MRE11	IPI	UniProtKB:O60934	Human	PMID:17500065
Molecular Function	GO:0005515	protein binding	MRE11	IPI	UniProtKB:P42858	Human	PMID:17500595
Molecular Function	GO:0005515	protein binding	MRE11	IPI	UniProtKB:O60934	Human	PMID:17612497
Molecular Function	GO:0005515	protein binding	MRE11	IPI	UniProtKB:P16104	Human	PMID:18583988
Molecular Function	GO:0005515	protein binding	MRE11	IPI	UniProtKB:Q99708	Human	PMID:18716619
Molecular Function	GO:0005515	protein binding	MRE11	IPI	UniProtKB:P16104	Human	PMID:19234442
Molecular Function	GO:0005515	protein binding	MRE11	IPI	UniProtKB:Q9BXW9	Human	PMID:19609304
Molecular Function	GO:0005515	protein binding	MRE11	IPI	UniProtKB:Q99708	Human	PMID:21052091
Molecular Function	GO:0005515	protein binding	MRE11	IPI	UniProtKB:O60934	Human	PMID:22078559
Molecular Function	GO:0005515	protein binding	MRE11	IPI	UniProtKB:P16104	Human	PMID:22157895
Molecular Function	GO:0005515	protein binding	MRE11	IPI	UniProtKB:O60341	Human	PMID:24529708
Molecular Function	GO:0005515	protein binding	MRE11	IPI	UniProtKB:O75943	Human	PMID:24534091
Molecular Function	GO:0005515	protein binding	MRE11	IPI	UniProtKB:Q61687	Human	PMID:24651726
Molecular Function	GO:0005515	protein binding	MRE11	IPI	UniProtKB:O60934	Human	PMID:24981860
Molecular Function	GO:0005515	protein binding	MRE11	IPI	UniProtKB:Q99708	Human	PMID:25558984
Molecular Function	GO:0005515	protein binding	MRE11	IPI	UniProtKB:P03243-1	Human	PMID:25772236
Molecular Function	GO:0005515	protein binding	MRE11	IPI	UniProtKB:P38398,UniProtKB:Q99708,UniProtKB:Q9NVH0	Human	PMID:26807646
Molecular Function	GO:0005515	protein binding	MRE11	IPI	UniProtKB:Q99708	Human	PMID:26807646
Molecular Function	GO:0005515	protein binding	MRE11	IPI	UniProtKB:Q6NTE8	Human	PMID:27568553
Molecular Function	GO:0005515	protein binding	MRE11	IPI	UniProtKB:Q9Y3Z3	Human	PMID:28834754
Molecular Function	GO:0005515	protein binding	MRE11	IPI	UniProtKB:Q9Y3Z3	Human	PMID:29670289
Molecular Function	GO:0005515	protein binding	MRE11	IPI	UniProtKB:Q9NRR5	Human	PMID:30612738
Molecular Function	GO:0005515	protein binding	MRE11	IPI	UniProtKB:O60934	Human	PMID:9590181
Molecular Function	GO:0005515	protein binding	Mre11a	IPI	UniProtKB:Q8BHZ5	Mouse	MGI:MGI:6202149|PMID:30017584
Molecular Function	GO:0005515	protein binding	Mre11a	IPI	UniProtKB:Q9R207	Mouse	MGI:MGI:3770108|PMID:17429352
Molecular Function	GO:0005515	protein binding	Mre11a	IPI	UniProtKB:Q9R207	Mouse	MGI:MGI:3839734|PMID:18854157
Molecular Function	GO:0005515	protein binding	Mre11	IPI	UniProtKB:P03243	Rat	PMID:18212738|RGD:2300253
Molecular Function	GO:0000014	single-stranded DNA endodeoxyribonuclease activity	MRE11	IDA		Human	PMID:9705271
Cellular Component	GO:0070533	BRCA1-C complex	MRE11	IPI		Human	PMID:16391231
Cellular Component	GO:0000785	chromatin	Mre11	IDA		Rat	PMID:10855503|RGD:2300257
Cellular Component	GO:0000781	chromosome, telomeric region	MRE11	IDA		Human	PMID:15149599
Cellular Component	GO:0000781	chromosome, telomeric region	MRE11	IDA		Human	PMID:24270157
Cellular Component	GO:0000781	chromosome, telomeric region	MRE11	IDA		Human	PMID:10811102
Cellular Component	GO:0000781	chromosome, telomeric region	MRE11	HDA		Human	PMID:19135898
Cellular Component	GO:0000781	chromosome, telomeric region	Mre11a	IDA		Mouse	MGI:MGI:5705215|PMID:23444137
Cellular Component	GO:0000794	condensed nuclear chromosome	Mre11	IDA		Rat	PMID:10855503|RGD:2300257
Cellular Component	GO:0005737	cytoplasm	MRE11	IDA		Human	PMID:25468996
Cellular Component	GO:0030870	Mre11 complex	MRE11	IPI		Human	PMID:31147924
Cellular Component	GO:0030870	Mre11 complex	MRE11	IDA		Human	PMID:10888888
Cellular Component	GO:0030870	Mre11 complex	MRE11	IDA		Human	PMID:19151086
Cellular Component	GO:0005654	nucleoplasm	MRE11	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	Mre11	IDA		Rat	PMID:16706843|RGD:2317719
Cellular Component	GO:0005634	nucleus	Mre11a	IDA		Mouse	PMID:15364958
Cellular Component	GO:0005634	nucleus	Mre11a	IDA		Mouse	PMID:12687013
Cellular Component	GO:0005634	nucleus	Mre11	IDA		Rat	PMID:18212738|RGD:2300253
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Mre11	IDA		Rat	PMID:18212738|RGD:2300253
Cellular Component	GO:0016605	PML body	MRE11	IDA		Human	PMID:10811102
Cellular Component	GO:0016605	PML body	Mre11a	IDA		Mouse	MGI:MGI:5705215|PMID:23444137
Cellular Component	GO:0005657	replication fork	MRE11	IDA		Human	PMID:29290612
Cellular Component	GO:0035861	site of double-strand break	MRE11	IDA		Human	PMID:15916964
Cellular Component	GO:0035861	site of double-strand break	MRE11	IDA		Human	PMID:30612738
Biological Process	GO:0008283	cell population proliferation	Mre11a	IMP		Mouse	PMID:9224597
Biological Process	GO:0051276	chromosome organization	Mre11a	IMP	MGI:MGI:3027036	Mouse	PMID:14690604
Biological Process	GO:0006974	DNA damage response	MRE11	IDA		Human	PMID:17500065
Biological Process	GO:0006974	DNA damage response	MRE11	IDA		Human	PMID:29670289
Biological Process	GO:0032508	DNA duplex unwinding	MRE11	IMP		Human	PMID:15790808
Biological Process	GO:0110025	DNA strand resection involved in replication fork processing	MRE11	IDA		Human	PMID:29670289
Biological Process	GO:0006302	double-strand break repair	Mre11a	IMP	MGI:MGI:3027036	Mouse	PMID:17291760
Biological Process	GO:0000724	double-strand break repair via homologous recombination	MRE11	IDA		Human	PMID:29670289
Biological Process	GO:0000724	double-strand break repair via homologous recombination	MRE11	IDA		Human	PMID:30612738
Biological Process	GO:0006303	double-strand break repair via nonhomologous end joining	MRE11	IDA		Human	PMID:9651580
Biological Process	GO:0007507	heart development	Mre11	IEP		Rat	PMID:10908350|RGD:68816
Biological Process	GO:0007129	homologous chromosome pairing at meiosis	Mre11a	IMP	MGI:MGI:3027036	Mouse	PMID:17291760
Biological Process	GO:0007095	mitotic G2 DNA damage checkpoint signaling	Mre11a	IMP	MGI:MGI:3027036	Mouse	PMID:14690604
Biological Process	GO:0031573	mitotic intra-S DNA damage checkpoint signaling	Mre11a	IMP	MGI:MGI:3027036	Mouse	PMID:14690604
Biological Process	GO:0031573	mitotic intra-S DNA damage checkpoint signaling	Mre11a	IMP	MGI:MGI:3027036	Mouse	PMID:18614044
Biological Process	GO:0043066	negative regulation of apoptotic process	MRE11	IMP		Human	PMID:16374507
Biological Process	GO:0046597	negative regulation of viral entry into host cell	Mre11	IMP		Rat	PMID:22850678|RGD:8693392
Biological Process	GO:0033674	positive regulation of kinase activity	MRE11	IDA		Human	PMID:15790808
Biological Process	GO:0031954	positive regulation of protein autophosphorylation	MRE11	IDA		Human	PMID:15790808
Biological Process	GO:0032206	positive regulation of telomere maintenance	MRE11	IMP		Human	PMID:16374507
Biological Process	GO:0007062	sister chromatid cohesion	MRE11	IMP		Human	PMID:15917200
Biological Process	GO:0031860	telomeric 3' overhang formation	MRE11	IMP		Human	PMID:16374507

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern