Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MRGPRX1,MRGPRX2,MRGPRX3
  • Mouse genes Mrgprb4
  • Rat genes Mrgprb4,Mrgprb5
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Mrgprb4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004930	G protein-coupled receptor activity	MRGPRX2	IDA		Human	PMID:12915402
Molecular Function	GO:0004930	G protein-coupled receptor activity	MRGPRX2	IDA		Human	PMID:22069323
Molecular Function	GO:0042923	neuropeptide binding	MRGPRX2	IPI	UniProtKB:O00230	Human	PMID:12915402
Molecular Function	GO:0005515	protein binding	MRGPRX3	IPI	UniProtKB:Q5BVD1	Human	PMID:32296183
Molecular Function	GO:0004888	transmembrane signaling receptor activity	MRGPRX1	IMP		Human	PMID:20004959
Biological Process	GO:0007166	cell surface receptor signaling pathway	MRGPRX1	IMP		Human	PMID:20004959
Biological Process	GO:0045576	mast cell activation	MRGPRX2	IDA		Human	PMID:25517090
Biological Process	GO:0043303	mast cell degranulation	MRGPRX2	IDA		Human	PMID:22069323
Biological Process	GO:0032467	positive regulation of cytokinesis	MRGPRX2	IMP		Human	PMID:22888021
Biological Process	GO:1902349	response to chloroquine	MRGPRX1	IMP		Human	PMID:20004959
Biological Process	GO:0007165	signal transduction	MRGPRX1	IMP		Human	PMID:26582731

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern