Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MRTFA
  • Mouse genes Mrtfa
  • Rat genes Mrtfa
  • Zfish genes mrtfaa,mrtfab
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Mrtfa

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003779	actin binding	MRTFA	IDA		Human	PMID:24440334
Molecular Function	GO:0003779	actin binding	Mrtfa	IDA		Mouse	PMID:15798203
Molecular Function	GO:0003785	actin monomer binding	Mrtfa	IDA		Mouse	MGI:MGI:3850304|PMID:19350017
Molecular Function	GO:0003785	actin monomer binding	Mrtfa	IDA		Mouse	MGI:MGI:6201987|PMID:17588931
Molecular Function	GO:0003785	actin monomer binding	Mrtfa	IDA		Mouse	MGI:MGI:6202299|PMID:12732141
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Mrtfa	IDA		Mouse	PMID:17991879
Molecular Function	GO:0043522	leucine zipper domain binding	MRTFA	IPI	UniProtKB:Q8IZQ8	Human	PMID:14970199
Molecular Function	GO:0060090	molecular adaptor activity	Mrtfa	EXP		Mouse	MGI:MGI:3822206|PMID:19008859
Molecular Function	GO:0005515	protein binding	MRTFA	IPI	UniProtKB:P11831	Human	PMID:12397177
Molecular Function	GO:0005515	protein binding	MRTFA	IPI	UniProtKB:P11831	Human	PMID:14565952
Molecular Function	GO:0005515	protein binding	MRTFA	IPI	UniProtKB:Q9ULH7	Human	PMID:14565952
Molecular Function	GO:0005515	protein binding	MRTFA	IPI	UniProtKB:P11831	Human	PMID:19350017
Molecular Function	GO:0005515	protein binding	MRTFA	IPI	UniProtKB:Q8N9R8	Human	PMID:19350017
Molecular Function	GO:0005515	protein binding	Mrtfa	IPI	UniProtKB:Q9JM73	Mouse	MGI:MGI:6202299|PMID:12732141
Molecular Function	GO:0005515	protein binding	Mrtfa	IPI	UniProtKB:P60709|UniProtKB:P68135	Mouse	MGI:MGI:3822206|PMID:19008859
Molecular Function	GO:0005515	protein binding	Mrtfa	IPI	UniProtKB:Q8C8N2|UniProtKB:Q9JM73	Mouse	MGI:MGI:3850304|PMID:19350017
Molecular Function	GO:0005515	protein binding	Mrtfa	IPI	UniProtKB:O00629|UniProtKB:Q14974	Mouse	MGI:MGI:4837297|PMID:20818336
Molecular Function	GO:0005515	protein binding	Mrtfa	IPI	PR:Q6PCM1	Mouse	PMID:17991879
Molecular Function	GO:0000976	transcription cis-regulatory region binding	Mrtfa	IDA		Mouse	PMID:17991879
Molecular Function	GO:0003713	transcription coactivator activity	MRTFA	IGI	UniProtKB:P11831	Human	PMID:23764775
Molecular Function	GO:0003713	transcription coactivator activity	Mrtfa	IDA		Mouse	MGI:MGI:6201987|PMID:17588931
Molecular Function	GO:0003713	transcription coactivator activity	Mrtfa	IDA		Mouse	MGI:MGI:6202299|PMID:12732141
Molecular Function	GO:0003713	transcription coactivator activity	Mrtfa	IDA		Mouse	MGI:MGI:6201839|PMID:24732378
Molecular Function	GO:0003713	transcription coactivator activity	Mrtfa	IDA		Mouse	MGI:MGI:3850304|PMID:19350017
Cellular Component	GO:0005737	cytoplasm	MRTFA	IDA		Human	PMID:14970199
Cellular Component	GO:0005737	cytoplasm	Mrtfa	IDA		Mouse	MGI:MGI:6202299|PMID:12732141
Cellular Component	GO:0005737	cytoplasm	Mrtfa	IDA		Mouse	MGI:MGI:6201987|PMID:17588931
Cellular Component	GO:0005737	cytoplasm	Mrtfa	IDA		Mouse	PMID:15798203
Cellular Component	GO:0005829	cytosol	MRTFA	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	MRTFA	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	MRTFA	IDA		Human	PMID:14970199
Cellular Component	GO:0005634	nucleus	MRTFA	IDA		Human	PMID:24440334
Cellular Component	GO:0005634	nucleus	Mrtfa	IDA		Mouse	MGI:MGI:6201987|PMID:17588931
Cellular Component	GO:0005634	nucleus	Mrtfa	IDA		Mouse	MGI:MGI:6202299|PMID:12732141
Cellular Component	GO:0005634	nucleus	Mrtfa	IDA		Mouse	PMID:15798203
Cellular Component	GO:0005634	nucleus	Mrtfa	IDA		Mouse	PMID:12019265
Cellular Component	GO:0005634	nucleus	Mrtfa	IDA		Rat	PMID:17005865|RGD:1599951
Biological Process	GO:0030036	actin cytoskeleton organization	Mrtfa	IDA		Mouse	MGI:MGI:6201839|PMID:24732378
Biological Process	GO:0030036	actin cytoskeleton organization	Mrtfa	IGI	MGI:MGI:3050795	Mouse	PMID:20534669
Biological Process	GO:0030900	forebrain development	Mrtfa	IGI	MGI:MGI:3050795	Mouse	PMID:20534669
Biological Process	GO:2001234	negative regulation of apoptotic signaling pathway	Mrtfa	IDA		Mouse	PMID:12019265
Biological Process	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	Mrtfa	IDA		Mouse	PMID:12019265
Biological Process	GO:0001764	neuron migration	Mrtfa	IGI	MGI:MGI:3050795	Mouse	PMID:20534669
Biological Process	GO:0031175	neuron projection development	Mrtfa	IGI	MGI:MGI:3050795	Mouse	PMID:20534669
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Mrtfa	IDA		Mouse	PMID:15798203
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Mrtfa	IDA		Mouse	PMID:12019265
Biological Process	GO:1902895	positive regulation of miRNA transcription	MRTFA	IGI	UniProtKB:P11831	Human	PMID:23764775
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	MRTFA	IDA		Human	PMID:14970199
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	MRTFA	IDA		Human	PMID:24440334
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Mrtfa	IDA		Mouse	MGI:MGI:6202299|PMID:12732141
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Mrtfa	IDA		Mouse	MGI:MGI:6201839|PMID:24732378
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Mrtfa	IDA		Mouse	MGI:MGI:6201987|PMID:17588931
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Mrtfa	IDA		Mouse	MGI:MGI:5688835|PMID:21984612
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Mrtfa	IDA		Mouse	PMID:18945672
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Mrtfa	IDA		Mouse	PMID:17991879
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	Mrtfa	IMP		Rat	PMID:17005865|RGD:1599951
Biological Process	GO:0051145	smooth muscle cell differentiation	MRTFA	IMP		Human	PMID:14970199
Biological Process	GO:0044319	wound healing, spreading of cells	MRTFA	IDA		Human	PMID:29391067

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern