Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MS4A2
  • Mouse genes Ms4a2
  • Rat genes Ms4a2
  • Zfish genes tmem176l.3a
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ms4a2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0019863	IgE binding	Ms4a2	IDA		Mouse	PMID:14764707
Molecular Function	GO:0019767	IgE receptor activity	Ms4a2	IDA		Rat	PMID:11388899|RGD:1599963
Molecular Function	GO:0051219	phosphoprotein binding	Ms4a2	IPI	RGD:3347	Rat	PMID:8910399|RGD:1599952
Molecular Function	GO:0051219	phosphoprotein binding	Ms4a2	IPI	RGD:619758	Rat	PMID:8910399|RGD:1599952
Molecular Function	GO:0051219	phosphoprotein binding	Ms4a2	IPI	RGD:620446	Rat	PMID:8910399|RGD:1599952
Molecular Function	GO:0005515	protein binding	MS4A2	IPI	UniProtKB:Q8N2M4	Human	PMID:32296183
Molecular Function	GO:0019901	protein kinase binding	Ms4a2	IPI	RGD:621017	Rat	PMID:16177098|RGD:1578516
Molecular Function	GO:0042169	SH2 domain binding	Ms4a2	IDA		Rat	PMID:8910399|RGD:1599952
Cellular Component	GO:0005768	endosome	Ms4a2	IDA		Rat	PMID:11101638|RGD:1599962
Cellular Component	GO:0009897	external side of plasma membrane	Ms4a2	IDA		Mouse	PMID:14764707
Cellular Component	GO:0009897	external side of plasma membrane	Ms4a2	IDA		Mouse	PMID:2527850
Cellular Component	GO:0032998	Fc-epsilon receptor I complex	Ms4a2	IDA		Mouse	PMID:14764707
Cellular Component	GO:0045121	membrane raft	Ms4a2	IDA		Rat	PMID:11388899|RGD:1599963
Cellular Component	GO:0005886	plasma membrane	Ms4a2	IDA		Mouse	PMID:2527850
Cellular Component	GO:0005886	plasma membrane	Ms4a2	IDA		Rat	PMID:2970642|RGD:728962
Biological Process	GO:0007202	activation of phospholipase C activity	Ms4a2	IDA		Rat	PMID:11388899|RGD:1599963
Biological Process	GO:0007166	cell surface receptor signaling pathway	Ms4a2	IDA		Mouse	PMID:9000133
Biological Process	GO:0006955	immune response	MS4A2	IMP		Human	PMID:7920628
Biological Process	GO:0006954	inflammatory response	Ms4a2	IMP		Rat	PMID:16177098|RGD:1578516
Biological Process	GO:0043306	positive regulation of mast cell degranulation	Ms4a2	IMP		Rat	PMID:16177098|RGD:1578516
Biological Process	GO:0007205	protein kinase C-activating G protein-coupled receptor signaling pathway	Ms4a2	IDA		Rat	PMID:11388899|RGD:1599963
Biological Process	GO:0051279	regulation of release of sequestered calcium ion into cytosol	Ms4a2	IGI	RGD:621017	Rat	PMID:16177098|RGD:1578516
Biological Process	GO:0007165	signal transduction	Ms4a2	IDA		Mouse	PMID:12192036
Biological Process	GO:0007165	signal transduction	Ms4a2	IMP		Rat	PMID:16177098|RGD:1578516

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern