Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MSH2
  • Mouse genes Msh2
  • Rat genes Msh2
  • Zfish genes msh2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Msh2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0043531	ADP binding	MSH2	IDA		Human	PMID:15105434
Molecular Function	GO:0005524	ATP binding	MSH2	IDA		Human	PMID:15105434
Molecular Function	GO:0016887	ATP hydrolysis activity	Msh2	IMP	MGI:MGI:2680817	Mouse	PMID:14568978
Molecular Function	GO:0008094	ATP-dependent activity, acting on DNA	MSH2	IDA		Human	PMID:16403449
Molecular Function	GO:0019237	centromeric DNA binding	Msh2	IDA		Mouse	PMID:16260499
Molecular Function	GO:0003682	chromatin binding	MSH2	IDA		Human	PMID:26300262
Molecular Function	GO:0003684	damaged DNA binding	Msh2	IMP	MGI:MGI:1858055	Mouse	PMID:7628020
Molecular Function	GO:0003684	damaged DNA binding	Msh2	IMP	MGI:MGI:1858055	Mouse	PMID:10545954
Molecular Function	GO:0032139	dinucleotide insertion or deletion binding	MSH2	IDA		Human	PMID:8942985
Molecular Function	GO:0032181	dinucleotide repeat insertion binding	MSH2	IDA		Human	PMID:8942985
Molecular Function	GO:0003677	DNA binding	MSH2	IDA		Human	PMID:7923193
Molecular Function	GO:0003677	DNA binding	Msh2	IMP	MGI:MGI:1858055	Mouse	PMID:10545954
Molecular Function	GO:0003690	double-stranded DNA binding	MSH2	IDA		Human	PMID:11809883
Molecular Function	GO:0000400	four-way junction DNA binding	MSH2	IDA		Human	PMID:12034830
Molecular Function	GO:0032137	guanine/thymine mispair binding	MSH2	IDA		Human	PMID:11809883
Molecular Function	GO:0032137	guanine/thymine mispair binding	MSH2	IDA		Human	PMID:8942985
Molecular Function	GO:0032137	guanine/thymine mispair binding	MSH2	IMP		Human	PMID:16713580
Molecular Function	GO:0032137	guanine/thymine mispair binding	Msh2	IDA		Mouse	PMID:16713580
Molecular Function	GO:0032137	guanine/thymine mispair binding	msh2	IGI	ZFIN:ZDB-GENE-020905-3	Zfish	PMID:15488992
Molecular Function	GO:0032137	guanine/thymine mispair binding	msh2	IDA		Zfish	PMID:15488992
Molecular Function	GO:0000287	magnesium ion binding	MSH2	IDA		Human	PMID:16403449
Molecular Function	GO:0030983	mismatched DNA binding	MSH2	IDA		Human	PMID:11756455
Molecular Function	GO:0030983	mismatched DNA binding	MSH2	IDA		Human	PMID:11801590
Molecular Function	GO:0030983	mismatched DNA binding	MSH2	IDA		Human	PMID:8942985
Molecular Function	GO:0030983	mismatched DNA binding	Msh2	IMP	MGI:MGI:1857940	Mouse	PMID:7550317
Molecular Function	GO:0030983	mismatched DNA binding	Msh2	IMP	MGI:MGI:2680817	Mouse	PMID:14744764
Molecular Function	GO:0032405	MutLalpha complex binding	MSH2	IDA		Human	PMID:16403449
Molecular Function	GO:0032357	oxidized purine DNA binding	MSH2	IDA		Human	PMID:11756455
Molecular Function	GO:0032357	oxidized purine DNA binding	MSH2	IDA		Human	PMID:11801590
Molecular Function	GO:0005515	protein binding	MSH2	IPI	UniProtKB:P52701	Human	PMID:10856833
Molecular Function	GO:0005515	protein binding	MSH2	IPI	UniProtKB:Q9UQ84	Human	PMID:10856833
Molecular Function	GO:0005515	protein binding	MSH2	IPI	UniProtKB:Q9UQ84-1	Human	PMID:10856833
Molecular Function	GO:0005515	protein binding	MSH2	IPI	UniProtKB:Q9UQ84	Human	PMID:11427529
Molecular Function	GO:0005515	protein binding	MSH2	IPI	UniProtKB:Q9UQ84	Human	PMID:11429708
Molecular Function	GO:0005515	protein binding	MSH2	IPI	UniProtKB:Q9UQ84	Human	PMID:12414623
Molecular Function	GO:0005515	protein binding	MSH2	IPI	UniProtKB:Q9UQ84-1	Human	PMID:12414623
Molecular Function	GO:0005515	protein binding	MSH2	IPI	UniProtKB:P20585	Human	PMID:14657349
Molecular Function	GO:0005515	protein binding	MSH2	IPI	UniProtKB:P52701	Human	PMID:14657349
Molecular Function	GO:0005515	protein binding	MSH2	IPI	UniProtKB:Q13535	Human	PMID:14657349
Molecular Function	GO:0005515	protein binding	MSH2	IPI	UniProtKB:Q8WXE1	Human	PMID:14657349
Molecular Function	GO:0005515	protein binding	MSH2	IPI	UniProtKB:Q9UQ84	Human	PMID:14676842
Molecular Function	GO:0005515	protein binding	MSH2	IPI	UniProtKB:P07992	Human	PMID:14706347
Molecular Function	GO:0005515	protein binding	MSH2	IPI	UniProtKB:P09429	Human	PMID:15014079
Molecular Function	GO:0005515	protein binding	MSH2	IPI	UniProtKB:P20585	Human	PMID:16025128
Molecular Function	GO:0005515	protein binding	MSH2	IPI	UniProtKB:P40692	Human	PMID:16403449
Molecular Function	GO:0005515	protein binding	MSH2	IPI	UniProtKB:Q14191	Human	PMID:17715146
Molecular Function	GO:0005515	protein binding	MSH2	IPI	UniProtKB:Q9H4L7	Human	PMID:18675275
Molecular Function	GO:0005515	protein binding	MSH2	IPI	UniProtKB:P20585	Human	PMID:19377479
Molecular Function	GO:0005515	protein binding	MSH2	IPI	UniProtKB:P52701	Human	PMID:19377479
Molecular Function	GO:0005515	protein binding	MSH2	IPI	UniProtKB:Q8IY92	Human	PMID:19596235
Molecular Function	GO:0005515	protein binding	MSH2	IPI	UniProtKB:P20585	Human	PMID:22179786
Molecular Function	GO:0005515	protein binding	MSH2	IPI	UniProtKB:P52701	Human	PMID:25241761
Molecular Function	GO:0005515	protein binding	MSH2	IPI	UniProtKB:O15379|UniProtKB:Q13547|UniProtKB:Q92769|UniProtKB:Q969S8|UniProtKB:Q96DB2|UniProtKB:Q9BY41|UniProtKB:Q9UKV0	Human	PMID:26221039
Molecular Function	GO:0005515	protein binding	MSH2	IPI	UniProtKB:Q9NXL9	Human	PMID:26300262
Molecular Function	GO:0005515	protein binding	MSH2	IPI	UniProtKB:Q9UJA3	Human	PMID:26300262
Molecular Function	GO:0005515	protein binding	MSH2	IPI	UniProtKB:P52701	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	MSH2	IPI	UniProtKB:Q92624	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MSH2	IPI	UniProtKB:P20585	Human	PMID:34591612
Molecular Function	GO:0005515	protein binding	MSH2	IPI	UniProtKB:P52701	Human	PMID:34591612
Molecular Function	GO:0005515	protein binding	MSH2	IPI	UniProtKB:P20585	Human	PMID:8942985
Molecular Function	GO:0005515	protein binding	MSH2	IPI	UniProtKB:P52701	Human	PMID:8942985
Molecular Function	GO:0005515	protein binding	MSH2	IPI	UniProtKB:P39875	Human	PMID:9207118
Molecular Function	GO:0005515	protein binding	MSH2	IPI	UniProtKB:P20585	Human	PMID:9774676
Molecular Function	GO:0005515	protein binding	MSH2	IPI	UniProtKB:P52701	Human	PMID:9774676
Molecular Function	GO:0005515	protein binding	MSH2	IPI	UniProtKB:Q9UQ84	Human	PMID:9788596
Molecular Function	GO:0042803	protein homodimerization activity	MSH2	IDA		Human	PMID:8942985
Molecular Function	GO:0032142	single guanine insertion binding	MSH2	IDA		Human	PMID:8942985
Molecular Function	GO:0032143	single thymine insertion binding	MSH2	IDA		Human	PMID:8942985
Molecular Function	GO:0003697	single-stranded DNA binding	MSH2	IDA		Human	PMID:11809883
Cellular Component	GO:0000781	chromosome, telomeric region	MSH2	HDA		Human	PMID:19135898
Cellular Component	GO:0016020	membrane	MSH2	HDA		Human	PMID:19946888
Cellular Component	GO:0032301	MutSalpha complex	MSH2	IPI		Human	PMID:17531815
Cellular Component	GO:0032301	MutSalpha complex	MSH2	IDA		Human	PMID:23622243
Cellular Component	GO:0032301	MutSalpha complex	MSH2	IDA		Human	PMID:8942985
Cellular Component	GO:0032301	MutSalpha complex	Msh2	IDA		Mouse	PMID:16713580
Cellular Component	GO:0032302	MutSbeta complex	MSH2	IPI		Human	PMID:22179786
Cellular Component	GO:0032302	MutSbeta complex	MSH2	IDA		Human	PMID:8942985
Cellular Component	GO:0005654	nucleoplasm	MSH2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	MSH2	IDA		Human	PMID:26300262
Cellular Component	GO:0005634	nucleus	Msh2	IDA		Mouse	PMID:9443401
Cellular Component	GO:0005634	nucleus	Msh2	IDA		Mouse	PMID:14744764
Cellular Component	GO:0005634	nucleus	Msh2	IDA		Rat	PMID:9473709|RGD:1580607
Biological Process	GO:0030183	B cell differentiation	Msh2	IMP	MGI:MGI:1858055	Mouse	PMID:9697843
Biological Process	GO:0019724	B cell mediated immunity	Msh2	IMP	MGI:MGI:1857940	Mouse	PMID:9927509
Biological Process	GO:0019724	B cell mediated immunity	Msh2	IMP	MGI:MGI:1858055	Mouse	PMID:9697843
Biological Process	GO:0008340	determination of adult lifespan	Msh2	IMP	MGI:MGI:1858055	Mouse	PMID:10545954
Biological Process	GO:0006974	DNA damage response	Msh2	IMP	MGI:MGI:1858055	Mouse	PMID:10720738
Biological Process	GO:0006974	DNA damage response	Msh2	IMP	MGI:MGI:1858055	Mouse	PMID:11429706
Biological Process	GO:0006974	DNA damage response	Msh2	IMP	MGI:MGI:2680817	Mouse	PMID:14744764
Biological Process	GO:0006974	DNA damage response	Msh2	IMP	MGI:MGI:1858055	Mouse	PMID:10097137
Biological Process	GO:0006281	DNA repair	MSH2	IDA		Human	PMID:8942985
Biological Process	GO:0006281	DNA repair	Msh2	IMP		Mouse	PMID:12687013
Biological Process	GO:0006302	double-strand break repair	Msh2	IMP	MGI:MGI:1858055	Mouse	PMID:17912366
Biological Process	GO:0007281	germ cell development	Msh2	IMP	MGI:MGI:1858055	Mouse	PMID:17912366
Biological Process	GO:0001701	in utero embryonic development	Msh2	IGI	MGI:MGI:98834	Mouse	PMID:9288110
Biological Process	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	Msh2	IMP	MGI:MGI:2680817	Mouse	PMID:14744764
Biological Process	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	Msh2	IMP	MGI:MGI:1858055	Mouse	PMID:10097137
Biological Process	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	Msh2	IGI	MGI:MGI:98834	Mouse	PMID:10097137
Biological Process	GO:0045190	isotype switching	Msh2	IMP	MGI:MGI:2151801	Mouse	PMID:10430621
Biological Process	GO:0045190	isotype switching	Msh2	IMP	MGI:MGI:1857940	Mouse	PMID:12743174
Biological Process	GO:0043570	maintenance of DNA repeat elements	MSH2	IMP		Human	PMID:16388310
Biological Process	GO:0043570	maintenance of DNA repeat elements	msh2	IMP	ZFIN:ZDB-GENO-090129-11	Zfish	PMID:18593904
Biological Process	GO:0008584	male gonad development	Msh2	IMP	MGI:MGI:1858055	Mouse	PMID:17912366
Biological Process	GO:0006298	mismatch repair	MSH2	IDA		Human	PMID:11555625
Biological Process	GO:0006298	mismatch repair	MSH2	IGI	UniProtKB:P40692	Human	PMID:23603115
Biological Process	GO:0006298	mismatch repair	MSH2	IGI	UniProtKB:P52701	Human	PMID:23603115
Biological Process	GO:0006298	mismatch repair	MSH2	IDA		Human	PMID:7923193
Biological Process	GO:0006298	mismatch repair	MSH2	IDA		Human	PMID:9677427
Biological Process	GO:0006298	mismatch repair	Msh2	IDA		Mouse	PMID:9244348
Biological Process	GO:0006298	mismatch repair	Msh2	IMP	MGI:MGI:1858055	Mouse	PMID:9697842
Biological Process	GO:0006298	mismatch repair	Msh2	IMP	MGI:MGI:1858055	Mouse	PMID:7628020
Biological Process	GO:0006298	mismatch repair	Msh2	IMP	MGI:MGI:1857940	Mouse	PMID:11046134
Biological Process	GO:0006298	mismatch repair	Msh2	IMP	MGI:MGI:1858055	Mouse	PMID:23071719
Biological Process	GO:0006298	mismatch repair	Msh2	IMP	MGI:MGI:1857940	Mouse	PMID:9288110
Biological Process	GO:0006298	mismatch repair	Msh2	IMP	MGI:MGI:1857940	Mouse	PMID:11890935
Biological Process	GO:0006298	mismatch repair	Msh2	IDA		Mouse	PMID:9157971
Biological Process	GO:0006298	mismatch repair	Msh2	IMP	MGI:MGI:1857940	Mouse	PMID:16728433
Biological Process	GO:0006298	mismatch repair	Msh2	IMP	MGI:MGI:2389314	Mouse	PMID:12531017
Biological Process	GO:0006298	mismatch repair	Msh2	IMP	MGI:MGI:1857940	Mouse	PMID:10874005
Biological Process	GO:0006298	mismatch repair	Msh2	IMP	MGI:MGI:1858055	Mouse	PMID:17331550
Biological Process	GO:0006298	mismatch repair	Msh2	IGI	MGI:MGI:109519	Mouse	PMID:16728433
Biological Process	GO:0006298	mismatch repair	Msh2	IMP	MGI:MGI:1857940	Mouse	PMID:8706033
Biological Process	GO:0006298	mismatch repair	Msh2	IMP	MGI:MGI:2680817	Mouse	PMID:14744764
Biological Process	GO:0006298	mismatch repair	Msh2	IMP	MGI:MGI:1858055	Mouse	PMID:10581038
Biological Process	GO:0006298	mismatch repair	Msh2	IMP	MGI:MGI:2151801	Mouse	PMID:10992298
Biological Process	GO:0031573	mitotic intra-S DNA damage checkpoint signaling	Msh2	IGI	MGI:MGI:103557	Mouse	PMID:15533840
Biological Process	GO:0045910	negative regulation of DNA recombination	MSH2	IDA		Human	PMID:17715146
Biological Process	GO:0045910	negative regulation of DNA recombination	Msh2	IMP	MGI:MGI:1858055	Mouse	PMID:10545954
Biological Process	GO:0045910	negative regulation of DNA recombination	Msh2	IMP	MGI:MGI:1858055	Mouse	PMID:7628020
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	Msh2	IMP	MGI:MGI:1857940	Mouse	PMID:16805809
Biological Process	GO:0006119	oxidative phosphorylation	Msh2	IMP	MGI:MGI:1857940	Mouse	PMID:16805809
Biological Process	GO:0051096	positive regulation of helicase activity	MSH2	IDA		Human	PMID:17715146
Biological Process	GO:0048298	positive regulation of isotype switching to IgA isotypes	Msh2	IMP		Mouse	MGI:MGI:1342394|PMID:10430621
Biological Process	GO:0048304	positive regulation of isotype switching to IgG isotypes	Msh2	IMP		Mouse	MGI:MGI:1342394|PMID:10430621
Biological Process	GO:0006301	postreplication repair	MSH2	IDA		Human	PMID:7923193
Biological Process	GO:0006301	postreplication repair	Msh2	IMP	MGI:MGI:1858055	Mouse	PMID:7628020
Biological Process	GO:0071168	protein localization to chromatin	MSH2	IMP		Human	PMID:26300262
Biological Process	GO:0051726	regulation of cell cycle	Msh2	IMP		Mouse	PMID:12687013
Biological Process	GO:0043200	response to amino acid	Msh2	IEP		Rat	PMID:11026496|RGD:2293525
Biological Process	GO:0014070	response to organic cyclic compound	Msh2	IEP		Rat	PMID:18095365|RGD:2292523
Biological Process	GO:0010224	response to UV-B	Msh2	IMP	MGI:MGI:1857940	Mouse	PMID:15166087
Biological Process	GO:0010165	response to X-ray	Msh2	IMP		Mouse	PMID:12687013
Biological Process	GO:0009410	response to xenobiotic stimulus	Msh2	IEP		Rat	PMID:11056294|RGD:727220
Biological Process	GO:0016446	somatic hypermutation of immunoglobulin genes	Msh2	IMP	MGI:MGI:1858055	Mouse	PMID:9697843
Biological Process	GO:0016446	somatic hypermutation of immunoglobulin genes	Msh2	IMP	MGI:MGI:2680817	Mouse	PMID:14568978
Biological Process	GO:0016446	somatic hypermutation of immunoglobulin genes	Msh2	IMP	MGI:MGI:1857940	Mouse	PMID:9607916
Biological Process	GO:0016446	somatic hypermutation of immunoglobulin genes	Msh2	IGI	MGI:MGI:109352	Mouse	PMID:15494304
Biological Process	GO:0016446	somatic hypermutation of immunoglobulin genes	Msh2	IMP	MGI:MGI:1858055	Mouse	PMID:9697842
Biological Process	GO:0016447	somatic recombination of immunoglobulin gene segments	Msh2	IMP	MGI:MGI:1857940	Mouse	PMID:14563316
Biological Process	GO:0016447	somatic recombination of immunoglobulin gene segments	Msh2	IGI	MGI:MGI:109352	Mouse	PMID:15494304
Biological Process	GO:0016447	somatic recombination of immunoglobulin gene segments	Msh2	IMP	MGI:MGI:2151801	Mouse	PMID:11828012
Biological Process	GO:0016447	somatic recombination of immunoglobulin gene segments	Msh2	IMP	MGI:MGI:2680817	Mouse	PMID:14568978
Biological Process	GO:0016447	somatic recombination of immunoglobulin gene segments	Msh2	IMP	MGI:MGI:1857940	Mouse	PMID:15955838
Biological Process	GO:0002204	somatic recombination of immunoglobulin genes involved in immune response	Msh2	IGI	MGI:MGI:101938	Mouse	PMID:12743174
Biological Process	GO:0007283	spermatogenesis	Msh2	IEP		Rat	PMID:10644444|RGD:727288
Biological Process	GO:0007283	spermatogenesis	Msh2	IEP		Rat	PMID:9034308|RGD:729069

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern