Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MSH6
  • Mouse genes Msh6
  • Rat genes Msh6
  • Zfish genes msh6
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Msh6

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0043531	ADP binding	MSH6	IDA		Human	PMID:15105434
Molecular Function	GO:0005524	ATP binding	MSH6	IDA		Human	PMID:15105434
Molecular Function	GO:0008094	ATP-dependent activity, acting on DNA	MSH6	IDA		Human	PMID:16403449
Molecular Function	GO:0003682	chromatin binding	Msh6	IDA		Mouse	PMID:16618598
Molecular Function	GO:0003684	damaged DNA binding	Msh6	IMP	MGI:MGI:2151803	Mouse	PMID:10545954
Molecular Function	GO:0003684	damaged DNA binding	Msh6	IGI	MGI:MGI:109519	Mouse	PMID:10545954
Molecular Function	GO:0003677	DNA binding	Msh6	IGI	MGI:MGI:109519	Mouse	PMID:10545954
Molecular Function	GO:0003677	DNA binding	Msh6	IMP	MGI:MGI:2151803	Mouse	PMID:10545954
Molecular Function	GO:0003690	double-stranded DNA binding	MSH6	IDA		Human	PMID:11809883
Molecular Function	GO:0003690	double-stranded DNA binding	msh6	IDA		Zfish	PMID:12945748
Molecular Function	GO:0019899	enzyme binding	MSH6	IPI	UniProtKB:Q9NXL9	Human	PMID:26300262
Molecular Function	GO:0000400	four-way junction DNA binding	MSH6	IDA		Human	PMID:12034830
Molecular Function	GO:0032137	guanine/thymine mispair binding	MSH6	IDA		Human	PMID:11809883
Molecular Function	GO:0032137	guanine/thymine mispair binding	MSH6	IDA		Human	PMID:8942985
Molecular Function	GO:0032137	guanine/thymine mispair binding	Msh6	IDA		Mouse	PMID:15324697
Molecular Function	GO:0032137	guanine/thymine mispair binding	Msh6	IDA		Mouse	PMID:16713580
Molecular Function	GO:0032137	guanine/thymine mispair binding	msh6	IGI	ZFIN:ZDB-GENE-040426-2932	Zfish	PMID:15488992
Molecular Function	GO:0000287	magnesium ion binding	MSH6	IDA		Human	PMID:16403449
Molecular Function	GO:0035064	methylated histone binding	MSH6	IDA		Human	PMID:23622243
Molecular Function	GO:0030983	mismatched DNA binding	MSH6	IDA		Human	PMID:11756455
Molecular Function	GO:0030983	mismatched DNA binding	MSH6	IDA		Human	PMID:11801590
Molecular Function	GO:0030983	mismatched DNA binding	MSH6	IDA		Human	PMID:8942985
Molecular Function	GO:0030983	mismatched DNA binding	MSH6	IDA		Human	PMID:23622243
Molecular Function	GO:0030983	mismatched DNA binding	msh6	IDA		Zfish	PMID:12945748
Molecular Function	GO:0032405	MutLalpha complex binding	MSH6	IDA		Human	PMID:16403449
Molecular Function	GO:0032357	oxidized purine DNA binding	MSH6	IDA		Human	PMID:11756455
Molecular Function	GO:0032357	oxidized purine DNA binding	MSH6	IDA		Human	PMID:11801590
Molecular Function	GO:0005515	protein binding	MSH6	IPI	UniProtKB:P43246	Human	PMID:10856833
Molecular Function	GO:0005515	protein binding	MSH6	IPI	UniProtKB:P12004	Human	PMID:11005803
Molecular Function	GO:0005515	protein binding	MSH6	IPI	UniProtKB:Q9UIF7	Human	PMID:11801590
Molecular Function	GO:0005515	protein binding	MSH6	IPI	UniProtKB:P43246	Human	PMID:14657349
Molecular Function	GO:0005515	protein binding	MSH6	IPI	UniProtKB:P40692	Human	PMID:16403449
Molecular Function	GO:0005515	protein binding	MSH6	IPI	UniProtKB:P43246	Human	PMID:19377479
Molecular Function	GO:0005515	protein binding	MSH6	IPI	UniProtKB:P43246	Human	PMID:25241761
Molecular Function	GO:0005515	protein binding	MSH6	IPI	UniProtKB:Q9NXL9	Human	PMID:26300262
Molecular Function	GO:0005515	protein binding	MSH6	IPI	UniProtKB:P43246	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	MSH6	IPI	UniProtKB:P43246	Human	PMID:34591612
Molecular Function	GO:0005515	protein binding	MSH6	IPI	UniProtKB:P40692	Human	PMID:8942985
Molecular Function	GO:0005515	protein binding	MSH6	IPI	UniProtKB:P43246	Human	PMID:8942985
Molecular Function	GO:0005515	protein binding	MSH6	IPI	UniProtKB:P43246	Human	PMID:9774676
Molecular Function	GO:0032142	single guanine insertion binding	MSH6	IDA		Human	PMID:8942985
Molecular Function	GO:0032143	single thymine insertion binding	MSH6	IDA		Human	PMID:8942985
Cellular Component	GO:0000785	chromatin	Msh6	IDA		Mouse	PMID:16618598
Cellular Component	GO:0005829	cytosol	MSH6	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005794	Golgi apparatus	MSH6	IDA		Human	GO_REF:0000052
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	MSH6	IDA		Human	GO_REF:0000052
Cellular Component	GO:0032301	MutSalpha complex	MSH6	IPI		Human	PMID:17531815
Cellular Component	GO:0032301	MutSalpha complex	MSH6	IDA		Human	PMID:23622243
Cellular Component	GO:0032301	MutSalpha complex	MSH6	IDA		Human	PMID:8942985
Cellular Component	GO:0032301	MutSalpha complex	Msh6	IDA		Mouse	PMID:16713580
Cellular Component	GO:0005654	nucleoplasm	MSH6	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	MSH6	IDA		Human	PMID:26300262
Biological Process	GO:0008340	determination of adult lifespan	Msh6	IMP	MGI:MGI:1858014	Mouse	PMID:9390556
Biological Process	GO:0008340	determination of adult lifespan	Msh6	IMP	MGI:MGI:2151803	Mouse	PMID:10545954
Biological Process	GO:0006281	DNA repair	MSH6	IDA		Human	PMID:8942985
Biological Process	GO:0097193	intrinsic apoptotic signaling pathway	Msh6	IMP	MGI:MGI:2151803	Mouse	PMID:14632208
Biological Process	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	Msh6	IMP	MGI:MGI:1858014	Mouse	PMID:15324697
Biological Process	GO:0045190	isotype switching	Msh6	IGI	MGI:MGI:109352	Mouse	PMID:17015724
Biological Process	GO:0045190	isotype switching	Msh6	IMP	MGI:MGI:3653701	Mouse	PMID:16618598
Biological Process	GO:0043570	maintenance of DNA repeat elements	msh6	IMP	ZFIN:ZDB-GENO-090129-10	Zfish	PMID:18593904
Biological Process	GO:0006298	mismatch repair	MSH6	IGI	UniProtKB:P40692	Human	PMID:23603115
Biological Process	GO:0006298	mismatch repair	MSH6	IGI	UniProtKB:P43246	Human	PMID:23603115
Biological Process	GO:0006298	mismatch repair	MSH6	IDA		Human	PMID:10871409
Biological Process	GO:0006298	mismatch repair	MSH6	IDA		Human	PMID:23622243
Biological Process	GO:0006298	mismatch repair	MSH6	IMP		Human	PMID:8782829
Biological Process	GO:0006298	mismatch repair	Msh6	IMP	MGI:MGI:1858014	Mouse	PMID:9390556
Biological Process	GO:0006298	mismatch repair	Msh6	IMP	MGI:MGI:1858014	Mouse	PMID:16728433
Biological Process	GO:0006298	mismatch repair	Msh6	IGI	MGI:MGI:109519	Mouse	PMID:16728433
Biological Process	GO:0006298	mismatch repair	Msh6	IMP	MGI:MGI:3653701	Mouse	PMID:15324697
Biological Process	GO:0006298	mismatch repair	Msh6	IMP	MGI:MGI:2151803	Mouse	PMID:23071719
Biological Process	GO:0006298	mismatch repair	Msh6	IMP	MGI:MGI:1858014	Mouse	PMID:12370835
Biological Process	GO:0006298	mismatch repair	Msh6	IGI	MGI:MGI:88039	Mouse	PMID:11691815
Biological Process	GO:0006298	mismatch repair	Msh6	IMP		Rat	PMID:18417481|RGD:2292505
Biological Process	GO:0045910	negative regulation of DNA recombination	MSH6	IDA		Human	PMID:17715146
Biological Process	GO:0045910	negative regulation of DNA recombination	Msh6	IMP	MGI:MGI:2151803	Mouse	PMID:10545954
Biological Process	GO:0051096	positive regulation of helicase activity	MSH6	IDA		Human	PMID:17715146
Biological Process	GO:0009411	response to UV	Msh6	IMP	MGI:MGI:1858014	Mouse	PMID:14632208
Biological Process	GO:0016446	somatic hypermutation of immunoglobulin genes	Msh6	IMP	MGI:MGI:1858014	Mouse	PMID:17015724
Biological Process	GO:0016446	somatic hypermutation of immunoglobulin genes	Msh6	IMP	MGI:MGI:1858014	Mouse	PMID:15238604
Biological Process	GO:0016446	somatic hypermutation of immunoglobulin genes	Msh6	IMP	MGI:MGI:1858014	Mouse	PMID:16618598
Biological Process	GO:0016446	somatic hypermutation of immunoglobulin genes	Msh6	IMP	MGI:MGI:1858014	Mouse	PMID:10662804
Biological Process	GO:0016446	somatic hypermutation of immunoglobulin genes	Msh6	IMP	MGI:MGI:3653701	Mouse	PMID:16618598
Biological Process	GO:0016447	somatic recombination of immunoglobulin gene segments	Msh6	IMP	MGI:MGI:1858014	Mouse	PMID:15238604
Biological Process	GO:0007283	spermatogenesis	Msh6	IEP		Rat	PMID:10644444|RGD:727288

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern