Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MST1,MST1L
  • Mouse genes Mst1
  • Rat genes Mst1
  • Zfish genes mst1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Mst1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0019899	enzyme binding	Mst1	IPI	RGD:3268	Rat	PMID:23647599|RGD:10448278
Molecular Function	GO:0035173	histone kinase activity	Mst1	IDA		Rat	PMID:21572393|RGD:9587767
Molecular Function	GO:0005515	protein binding	MST1	IPI	UniProtKB:Q04912	Human	PMID:22087277
Molecular Function	GO:0005515	protein binding	MST1	IPI	UniProtKB:Q15831	Human	PMID:24362629
Molecular Function	GO:0005515	protein binding	MST1	IPI	UniProtKB:Q04912	Human	PMID:25193665
Molecular Function	GO:0005515	protein binding	MST1	IPI	UniProtKB:Q8WV19	Human	PMID:32296183
Molecular Function	GO:0030971	receptor tyrosine kinase binding	MST1	IDA		Human	PMID:22087277
Cellular Component	GO:0062023	collagen-containing extracellular matrix	MST1	HDA		Human	PMID:25037231
Cellular Component	GO:0005737	cytoplasm	Mst1	IDA		Rat	PMID:23647599|RGD:10448278
Cellular Component	GO:0005615	extracellular space	MST1	IDA		Human	PMID:7508914
Cellular Component	GO:0005773	vacuole	Mst1	IDA		Mouse	PMID:25049204
Biological Process	GO:0030282	bone mineralization	mst1	IMP	ZFIN:ZDB-GENO-121128-5	Zfish	PMID:22787265
Biological Process	GO:0071456	cellular response to hypoxia	Mst1	IEP		Rat	PMID:23647599|RGD:10448278
Biological Process	GO:0071346	cellular response to type II interferon	Mst1	IEP		Rat	PMID:21572393|RGD:9587767
Biological Process	GO:0007566	embryo implantation	Mst1	IDA		Mouse	PMID:12606483
Biological Process	GO:0030317	flagellated sperm motility	Mst1	IEP		Rat	PMID:8858136|RGD:633226
Biological Process	GO:0016570	histone modification	Mst1	IMP		Rat	PMID:21572393|RGD:9587767
Biological Process	GO:0006954	inflammatory response	mst1	IMP		Zfish	PMID:25353089
Biological Process	GO:0060763	mammary duct terminal end bud growth	Mst1	IMP	MGI:MGI:2445230	Mouse	PMID:25049204
Biological Process	GO:0030879	mammary gland development	Mst1	IMP	MGI:MGI:2445230	Mouse	PMID:25049204
Biological Process	GO:1904036	negative regulation of epithelial cell apoptotic process	Mst1	IMP	MGI:MGI:2445230	Mouse	PMID:25049204
Biological Process	GO:0045721	negative regulation of gluconeogenesis	MST1	IDA		Human	PMID:19720831
Biological Process	GO:0043065	positive regulation of apoptotic process	Mst1	IMP		Rat	PMID:21572393|RGD:9587767
Biological Process	GO:0010628	positive regulation of gene expression	Mst1	IMP	MGI:MGI:2445230	Mouse	PMID:25049204
Biological Process	GO:0033601	positive regulation of mammary gland epithelial cell proliferation	Mst1	IMP	MGI:MGI:2445230	Mouse	PMID:25049204
Biological Process	GO:2000479	regulation of cAMP-dependent protein kinase activity	MST1	IDA		Human	PMID:19720831
Biological Process	GO:0010758	regulation of macrophage chemotaxis	Mst1	IMP	MGI:MGI:2445230	Mouse	PMID:25049204
Biological Process	GO:0046425	regulation of receptor signaling pathway via JAK-STAT	Mst1	IMP	MGI:MGI:2445230	Mouse	PMID:25049204
Biological Process	GO:0007283	spermatogenesis	Mst1	IEP		Rat	PMID:8858136|RGD:633226

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern