Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MT1A,MT1B,MT1E,MT1F,MT1G,MT1H,MT1L,MT1X,MT2A
  • Mouse genes Mt2
  • Rat genes Mt1m,Mt2A
  • Zfish genes mt2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Mt2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0046870	cadmium ion binding	Mt2A	IDA		Rat	PMID:1438200|RGD:6483849
Molecular Function	GO:0005515	protein binding	MT2A	IPI	UniProtKB:P58062	Human	PMID:12646258
Molecular Function	GO:0005515	protein binding	MT2A	IPI	UniProtKB:P58062	Human	PMID:12970870
Molecular Function	GO:0005515	protein binding	MT2A	IPI	UniProtKB:Q15139	Human	PMID:14550308
Molecular Function	GO:0005515	protein binding	MT2A	IPI	UniProtKB:Q8TE69	Human	PMID:15541360
Molecular Function	GO:0005515	protein binding	MT2A	IPI	UniProtKB:D3DTS7	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	MT2A	IPI	UniProtKB:O14645	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	MT2A	IPI	UniProtKB:O14901	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	MT2A	IPI	UniProtKB:P02649	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	MT2A	IPI	UniProtKB:P14678-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	MT2A	IPI	UniProtKB:P21333-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	MT2A	IPI	UniProtKB:P31153	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	MT2A	IPI	UniProtKB:P37840	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	MT2A	IPI	UniProtKB:P42858	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	MT2A	IPI	UniProtKB:Q96A83-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	MT2A	IPI	UniProtKB:Q9BVL2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	MT2A	IPI	UniProtKB:Q9UMF0	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	MT1A	IPI	UniProtKB:P04637	Human	PMID:16442532
Molecular Function	GO:0005515	protein binding	MT1A	IPI	UniProtKB:Q13585	Human	PMID:16778767
Molecular Function	GO:0005515	protein binding	MT1E	IPI	UniProtKB:Q2TAC2-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MT1F	IPI	UniProtKB:P46087	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	MT1B	IPI	UniProtKB:P49901	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MT1B	IPI	UniProtKB:P60371	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MT1B	IPI	UniProtKB:Q07627	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MT1B	IPI	UniProtKB:Q701N4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MT1B	IPI	UniProtKB:Q9BYP8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MT1G	IPI	UniProtKB:P58062	Human	PMID:12646258
Molecular Function	GO:0005515	protein binding	MT1G	IPI	UniProtKB:P58062	Human	PMID:12970870
Molecular Function	GO:0005515	protein binding	MT1H	IPI	UniProtKB:P58062	Human	PMID:12646258
Molecular Function	GO:0005515	protein binding	MT1H	IPI	UniProtKB:P58062	Human	PMID:12970870
Molecular Function	GO:0005515	protein binding	MT1H	IPI	UniProtKB:Q96KC8	Human	PMID:14668352
Molecular Function	GO:0005515	protein binding	MT1X	IPI	UniProtKB:Q9NYB0	Human	PMID:21044950
Molecular Function	GO:0005515	protein binding	MT1X	IPI	UniProtKB:Q92567	Human	PMID:23251525
Molecular Function	GO:0005515	protein binding	MT1X	IPI	UniProtKB:Q8N1H7	Human	PMID:32296183
Molecular Function	GO:0008270	zinc ion binding	MT1G	IDA		Human	PMID:8119276
Molecular Function	GO:0008270	zinc ion binding	Mt2A	IDA		Rat	PMID:1438200|RGD:6483849
Cellular Component	GO:0005737	cytoplasm	MT1E	IDA		Human	PMID:8619255
Cellular Component	GO:0005737	cytoplasm	MT1F	IDA		Human	PMID:8619255
Cellular Component	GO:0005737	cytoplasm	MT1G	IDA		Human	PMID:3403543
Cellular Component	GO:0005737	cytoplasm	MT1X	IDA		Human	PMID:8619255
Cellular Component	GO:0005634	nucleus	MT1E	IDA		Human	PMID:8619255
Cellular Component	GO:0005634	nucleus	MT1F	IDA		Human	PMID:8619255
Cellular Component	GO:0005634	nucleus	MT1G	IDA		Human	PMID:15735762
Cellular Component	GO:0005634	nucleus	MT1G	IDA		Human	PMID:7559655
Cellular Component	GO:0005634	nucleus	MT1X	IDA		Human	PMID:8619255
Biological Process	GO:0001525	angiogenesis	mt2	IMP	ZFIN:ZDB-MRPHLNO-160114-2	Zfish	PMID:26198291
Biological Process	GO:0001525	angiogenesis	mt2	IMP	ZFIN:ZDB-GENO-160429-6	Zfish	PMID:26198291
Biological Process	GO:0001525	angiogenesis	mt2	IMP	ZFIN:ZDB-GENO-160429-7	Zfish	PMID:26198291
Biological Process	GO:0048143	astrocyte activation	Mt2A	IEP		Rat	PMID:19837066|RGD:6483825
Biological Process	GO:0071276	cellular response to cadmium ion	MT1A	IEP		Human	PMID:16827180
Biological Process	GO:0071276	cellular response to cadmium ion	MT1E	IEP		Human	PMID:16827180
Biological Process	GO:0071276	cellular response to cadmium ion	MT1F	IEP		Human	PMID:16827180
Biological Process	GO:0071276	cellular response to cadmium ion	MT1G	IEP		Human	PMID:16827180
Biological Process	GO:0071276	cellular response to cadmium ion	MT1G	IEP		Human	PMID:19330122
Biological Process	GO:0071276	cellular response to cadmium ion	MT1G	IEP		Human	PMID:3403543
Biological Process	GO:0071276	cellular response to cadmium ion	MT1H	IEP		Human	PMID:16827180
Biological Process	GO:0071276	cellular response to cadmium ion	MT1X	IEP		Human	PMID:16827180
Biological Process	GO:0071280	cellular response to copper ion	MT1G	IEP		Human	PMID:3403543
Biological Process	GO:0036018	cellular response to erythropoietin	MT2A	IEP		Human	PMID:11168427
Biological Process	GO:0036018	cellular response to erythropoietin	MT1X	IEP		Human	PMID:11168427
Biological Process	GO:0036016	cellular response to interleukin-3	MT2A	IEP		Human	PMID:11168427
Biological Process	GO:0035924	cellular response to vascular endothelial growth factor stimulus	MT1G	IEP		Human	PMID:15735762
Biological Process	GO:0071294	cellular response to zinc ion	MT2A	IEP		Human	PMID:11168427
Biological Process	GO:0071294	cellular response to zinc ion	MT1A	IEP		Human	PMID:11168427
Biological Process	GO:0071294	cellular response to zinc ion	MT1E	IEP		Human	PMID:11168427
Biological Process	GO:0071294	cellular response to zinc ion	MT1E	IEP		Human	PMID:8119276
Biological Process	GO:0071294	cellular response to zinc ion	MT1B	IEP		Human	PMID:11168427
Biological Process	GO:0071294	cellular response to zinc ion	MT1G	IEP		Human	PMID:11168427
Biological Process	GO:0071294	cellular response to zinc ion	MT1G	IEP		Human	PMID:15735762
Biological Process	GO:0071294	cellular response to zinc ion	MT1G	IEP		Human	PMID:3403543
Biological Process	GO:0071294	cellular response to zinc ion	MT1G	IDA		Human	PMID:7559655
Biological Process	GO:0071294	cellular response to zinc ion	MT1G	IEP		Human	PMID:8119276
Biological Process	GO:0071294	cellular response to zinc ion	MT1H	IEP		Human	PMID:11168427
Biological Process	GO:0071294	cellular response to zinc ion	MT1H	IEP		Human	PMID:8119276
Biological Process	GO:0071294	cellular response to zinc ion	MT1X	IEP		Human	PMID:11168427
Biological Process	GO:0071294	cellular response to zinc ion	MT1L	IEP		Human	PMID:8119276
Biological Process	GO:0010273	detoxification of copper ion	Mt2	IMP	MGI:MGI:97171	Mouse	PMID:8640230
Biological Process	GO:0010273	detoxification of copper ion	Mt2	IMP	MGI:MGI:99400	Mouse	PMID:8640230
Biological Process	GO:0006882	intracellular zinc ion homeostasis	Mt2	IMP	MGI:MGI:2668455	Mouse	PMID:11792622
Biological Process	GO:0045926	negative regulation of growth	MT1G	IDA		Human	PMID:18332874
Biological Process	GO:0007263	nitric oxide mediated signal transduction	Mt2	IMP	MGI:MGI:2668455	Mouse	PMID:11792622
Biological Process	GO:0090050	positive regulation of cell migration involved in sprouting angiogenesis	mt2	IMP	ZFIN:ZDB-MRPHLNO-160114-2	Zfish	PMID:26198291
Biological Process	GO:0010575	positive regulation of vascular endothelial growth factor production	mt2	IMP	ZFIN:ZDB-MRPHLNO-160114-2	Zfish	PMID:26198291
Biological Process	GO:0010575	positive regulation of vascular endothelial growth factor production	mt2	IMP	ZFIN:ZDB-GENO-160429-6	Zfish	PMID:26198291
Biological Process	GO:0009617	response to bacterium	Mt2	IEP		Mouse	PMID:23012479
Biological Process	GO:0046686	response to cadmium ion	mt2	IEP		Zfish	PMID:16799861
Biological Process	GO:0046688	response to copper ion	mt2	IDA		Zfish	PMID:18987288
Biological Process	GO:0010038	response to metal ion	mt2	IDA		Zfish	PMID:16690118
Biological Process	GO:0010038	response to metal ion	mt2	IDA		Zfish	PMID:26354112
Biological Process	GO:0010038	response to metal ion	mt2	IDA		Zfish	PMID:18987288
Biological Process	GO:0010038	response to metal ion	mt2	IDA		Zfish	PMID:15245916
Biological Process	GO:0051597	response to methylmercury	mt2	IDA		Zfish	PMID:15984772
Biological Process	GO:0010043	response to zinc ion	mt2	IDA		Zfish	PMID:18477665

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern