Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MT3
  • Mouse genes Mt3
  • Rat genes Mt3
  • Zfish genes mt2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Mt3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0046870	cadmium ion binding	MT3	IDA		Human	PMID:16601975
Molecular Function	GO:0046870	cadmium ion binding	MT3	IDA		Human	PMID:17712581
Molecular Function	GO:0046870	cadmium ion binding	MT3	IDA		Human	PMID:18157556
Molecular Function	GO:0005507	copper ion binding	MT3	IDA		Human	PMID:21320589
Molecular Function	GO:0005507	copper ion binding	Mt3	IDA		Rat	PMID:12058024|RGD:625483
Molecular Function	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process	MT3	IDA		Human	PMID:16387743
Molecular Function	GO:0046872	metal ion binding	Mt3	IDA		Mouse	PMID:12130647
Molecular Function	GO:0005515	protein binding	MT3	IPI	UniProtKB:P02766	Human	PMID:20646067
Molecular Function	GO:0005515	protein binding	MT3	IPI	UniProtKB:Q9NYB0	Human	PMID:21044950
Molecular Function	GO:0005515	protein binding	MT3	IPI	UniProtKB:P37840	Human	PMID:21320589
Molecular Function	GO:0030295	protein kinase activator activity	MT3	IDA		Human	PMID:18295594
Molecular Function	GO:0008270	zinc ion binding	MT3	IDA		Human	PMID:17712581
Molecular Function	GO:0008270	zinc ion binding	MT3	IDA		Human	PMID:21320589
Molecular Function	GO:0008270	zinc ion binding	Mt3	IDA		Mouse	MGI:MGI:68875|PMID:7931547
Molecular Function	GO:0008270	zinc ion binding	Mt3	IDA		Rat	PMID:12058024|RGD:625483
Cellular Component	GO:0097450	astrocyte end-foot	Mt3	IDA		Rat	PMID:8911664|RGD:9685810
Cellular Component	GO:0097449	astrocyte projection	Mt3	IDA		Rat	PMID:9001723|RGD:9685808
Cellular Component	GO:0030424	axon	Mt3	IDA		Rat	PMID:8911664|RGD:9685810
Cellular Component	GO:0005737	cytoplasm	MT3	IDA		Human	PMID:10355541
Cellular Component	GO:0043197	dendritic spine	Mt3	IDA		Rat	PMID:8911664|RGD:9685810
Cellular Component	GO:0005615	extracellular space	Mt3	IDA		Rat	PMID:12058024|RGD:625483
Cellular Component	GO:0016234	inclusion body	MT3	IDA		Human	PMID:20039155
Cellular Component	GO:0005874	microtubule	Mt3	IDA		Rat	PMID:8911664|RGD:9685810
Cellular Component	GO:0005741	mitochondrial outer membrane	Mt3	IDA		Rat	PMID:8911664|RGD:9685810
Cellular Component	GO:0048471	perinuclear region of cytoplasm	MT3	IDA		Human	PMID:20039155
Cellular Component	GO:0005886	plasma membrane	Mt3	IDA		Rat	PMID:8911664|RGD:9685810
Cellular Component	GO:0014069	postsynaptic density	Mt3	IDA		Rat	PMID:8911664|RGD:9685810
Cellular Component	GO:0005840	ribosome	Mt3	IDA		Rat	PMID:8911664|RGD:9685810
Cellular Component	GO:0005791	rough endoplasmic reticulum	Mt3	IDA		Rat	PMID:8911664|RGD:9685810
Cellular Component	GO:0008021	synaptic vesicle	Mt3	IDA		Mouse	MGI:MGI:68875|PMID:7931547
Cellular Component	GO:0008021	synaptic vesicle	Mt3	IDA		Rat	PMID:8911664|RGD:9685810
Biological Process	GO:0032148	activation of protein kinase B activity	MT3	IDA		Human	PMID:18295594
Biological Process	GO:0001525	angiogenesis	mt2	IMP	ZFIN:ZDB-MRPHLNO-160114-2	Zfish	PMID:26198291
Biological Process	GO:0001525	angiogenesis	mt2	IMP	ZFIN:ZDB-GENO-160429-6	Zfish	PMID:26198291
Biological Process	GO:0001525	angiogenesis	mt2	IMP	ZFIN:ZDB-GENO-160429-7	Zfish	PMID:26198291
Biological Process	GO:0014002	astrocyte development	Mt3	IDA		Mouse	MGI:MGI:4881636|PMID:20544854
Biological Process	GO:0007420	brain development	Mt3	IEP		Rat	PMID:10407136|RGD:9685800
Biological Process	GO:0044242	cellular lipid catabolic process	Mt3	IMP		Mouse	MGI:MGI:4881636|PMID:20544854
Biological Process	GO:0071276	cellular response to cadmium ion	MT3	IDA		Human	PMID:16387743
Biological Process	GO:0071456	cellular response to hypoxia	MT3	IEP		Human	PMID:18206644
Biological Process	GO:0034599	cellular response to oxidative stress	MT3	IEP		Human	PMID:20039155
Biological Process	GO:0034599	cellular response to oxidative stress	Mt3	IDA		Mouse	MGI:MGI:4881636|PMID:20544854
Biological Process	GO:0034614	cellular response to reactive oxygen species	MT3	IDA		Human	PMID:18554677
Biological Process	GO:0006707	cholesterol catabolic process	Mt3	IMP		Mouse	MGI:MGI:4881636|PMID:20544854
Biological Process	GO:0071585	detoxification of cadmium ion	Mt3	IMP		Mouse	MGI:MGI:5315682|PMID:20371971
Biological Process	GO:0006112	energy reserve metabolic process	Mt3	IMP		Mouse	MGI:MGI:5299282|PMID:21726645
Biological Process	GO:0070371	ERK1 and ERK2 cascade	MT3	IDA		Human	PMID:18554677
Biological Process	GO:0016570	histone modification	MT3	IMP		Human	PMID:21818286
Biological Process	GO:0030003	intracellular monoatomic cation homeostasis	Mt3	IDA		Mouse	PMID:12130647
Biological Process	GO:0006882	intracellular zinc ion homeostasis	Mt3	IDA		Mouse	MGI:MGI:5315330|PMID:21359432
Biological Process	GO:0006882	intracellular zinc ion homeostasis	Mt3	IMP		Mouse	MGI:MGI:5299282|PMID:21726645
Biological Process	GO:0006882	intracellular zinc ion homeostasis	Mt3	IDA		Mouse	MGI:MGI:4881636|PMID:20544854
Biological Process	GO:0033210	leptin-mediated signaling pathway	Mt3	IMP		Mouse	MGI:MGI:5299282|PMID:21726645
Biological Process	GO:0043066	negative regulation of apoptotic process	MT3	IDA		Human	PMID:15129022
Biological Process	GO:0043066	negative regulation of apoptotic process	MT3	IDA		Human	PMID:18554677
Biological Process	GO:0043066	negative regulation of apoptotic process	Mt3	IMP		Mouse	MGI:MGI:4430172|PMID:19635467
Biological Process	GO:0010507	negative regulation of autophagy	Mt3	IMP		Mouse	MGI:MGI:4881636|PMID:20544854
Biological Process	GO:0030517	negative regulation of axon extension	MT3	IDA		Human	PMID:16601975
Biological Process	GO:0030517	negative regulation of axon extension	MT3	IDA		Human	PMID:17712581
Biological Process	GO:0030308	negative regulation of cell growth	MT3	IDA		Human	PMID:16601975
Biological Process	GO:0030308	negative regulation of cell growth	MT3	IMP		Human	PMID:16945328
Biological Process	GO:0030308	negative regulation of cell growth	MT3	IDA		Human	PMID:17712581
Biological Process	GO:2000117	negative regulation of cysteine-type endopeptidase activity	MT3	IDA		Human	PMID:18554677
Biological Process	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	MT3	IDA		Human	PMID:16387743
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Mt3	IMP		Mouse	MGI:MGI:4881636|PMID:20544854
Biological Process	GO:2000296	negative regulation of hydrogen peroxide catabolic process	Mt3	IDA		Rat	PMID:12058024|RGD:625483
Biological Process	GO:0060547	negative regulation of necrotic cell death	MT3	IDA		Human	PMID:18554677
Biological Process	GO:0060547	negative regulation of necrotic cell death	Mt3	IMP		Mouse	MGI:MGI:5315682|PMID:20371971
Biological Process	GO:0050768	negative regulation of neurogenesis	Mt3	IDA		Mouse	PMID:12130647
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	Mt3	IDA		Mouse	MGI:MGI:5315330|PMID:21359432
Biological Process	GO:1901215	negative regulation of neuron death	Mt3	IDA		Rat	PMID:14625437|RGD:9685806
Biological Process	GO:0051354	negative regulation of oxidoreductase activity	MT3	IDA		Human	PMID:21320589
Biological Process	GO:2000378	negative regulation of reactive oxygen species metabolic process	MT3	IDA		Human	PMID:18554677
Biological Process	GO:0043085	positive regulation of catalytic activity	Mt3	IMP		Mouse	MGI:MGI:4881636|PMID:20544854
Biological Process	GO:0010942	positive regulation of cell death	MT3	IDA		Human	PMID:16387743
Biological Process	GO:0010942	positive regulation of cell death	Mt3	IMP		Mouse	MGI:MGI:4881636|PMID:20544854
Biological Process	GO:0090050	positive regulation of cell migration involved in sprouting angiogenesis	mt2	IMP	ZFIN:ZDB-MRPHLNO-160114-2	Zfish	PMID:26198291
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	MT3	IDA		Human	PMID:18295594
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Mt3	IMP		Mouse	MGI:MGI:5299282|PMID:21726645
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	MT3	IDA		Human	PMID:18295594
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	Mt3	IMP		Mouse	MGI:MGI:5299282|PMID:21726645
Biological Process	GO:0010628	positive regulation of gene expression	MT3	IDA		Human	PMID:18295594
Biological Process	GO:0010628	positive regulation of gene expression	Mt3	IMP		Mouse	MGI:MGI:4881636|PMID:20544854
Biological Process	GO:0097214	positive regulation of lysosomal membrane permeability	Mt3	IMP		Mouse	MGI:MGI:4881636|PMID:20544854
Biological Process	GO:0010940	positive regulation of necrotic cell death	MT3	IDA		Human	PMID:15129022
Biological Process	GO:0010940	positive regulation of necrotic cell death	MT3	IDA		Human	PMID:16387743
Biological Process	GO:2000376	positive regulation of oxygen metabolic process	Mt3	IMP		Mouse	MGI:MGI:5299282|PMID:21726645
Biological Process	GO:0001934	positive regulation of protein phosphorylation	MT3	IDA		Human	PMID:18295594
Biological Process	GO:0010575	positive regulation of vascular endothelial growth factor production	mt2	IMP	ZFIN:ZDB-MRPHLNO-160114-2	Zfish	PMID:26198291
Biological Process	GO:0010575	positive regulation of vascular endothelial growth factor production	mt2	IMP	ZFIN:ZDB-GENO-160429-6	Zfish	PMID:26198291
Biological Process	GO:0030949	positive regulation of vascular endothelial growth factor receptor signaling pathway	MT3	IDA		Human	PMID:18295594
Biological Process	GO:0043491	protein kinase B signaling	MT3	IDA		Human	PMID:18554677
Biological Process	GO:0050821	protein stabilization	MT3	IDA		Human	PMID:18295594
Biological Process	GO:0060049	regulation of protein glycosylation	Mt3	IMP		Mouse	MGI:MGI:4881636|PMID:20544854
Biological Process	GO:0032095	regulation of response to food	Mt3	IMP		Mouse	MGI:MGI:5299282|PMID:21726645
Biological Process	GO:0019430	removal of superoxide radicals	MT3	IDA		Human	PMID:12383939
Biological Process	GO:0046686	response to cadmium ion	mt2	IEP		Zfish	PMID:16799861
Biological Process	GO:0046688	response to copper ion	mt2	IDA		Zfish	PMID:18987288
Biological Process	GO:0001666	response to hypoxia	MT3	IDA		Human	PMID:12763630
Biological Process	GO:0010038	response to metal ion	mt2	IDA		Zfish	PMID:16690118
Biological Process	GO:0010038	response to metal ion	mt2	IDA		Zfish	PMID:26354112
Biological Process	GO:0010038	response to metal ion	mt2	IDA		Zfish	PMID:18987288
Biological Process	GO:0010038	response to metal ion	mt2	IDA		Zfish	PMID:15245916
Biological Process	GO:0051597	response to methylmercury	mt2	IDA		Zfish	PMID:15984772
Biological Process	GO:0006979	response to oxidative stress	Mt3	IMP		Mouse	MGI:MGI:4430172|PMID:19635467
Biological Process	GO:0010043	response to zinc ion	mt2	IDA		Zfish	PMID:18477665
Biological Process	GO:0051238	sequestering of metal ion	Mt3	IMP		Mouse	MGI:MGI:5315682|PMID:20371971
Biological Process	GO:0006829	zinc ion transport	Mt3	IDA		Mouse	MGI:MGI:5315330|PMID:21359432

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern