Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MTCH2
  • Mouse genes Mtch2
  • Rat genes Mtch2
  • Zfish genes mtch2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Mtch2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0032977	membrane insertase activity	MTCH2	IDA		Human	PMID:36264797
Molecular Function	GO:0005515	protein binding	MTCH2	IPI	UniProtKB:P02654	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MTCH2	IPI	UniProtKB:P56378-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Mtch2	IPI	PR:P70444	Mouse	PMID:20436477
Cellular Component	GO:0016020	membrane	MTCH2	HDA		Human	PMID:19946888
Cellular Component	GO:0005743	mitochondrial inner membrane	Mtch2	HDA		Mouse	PMID:12865426
Cellular Component	GO:0005741	mitochondrial outer membrane	MTCH2	IDA		Human	PMID:36264797
Cellular Component	GO:0005741	mitochondrial outer membrane	Mtch2	IDA		Mouse	PMID:20436477
Cellular Component	GO:0005739	mitochondrion	Mtch2	HDA		Mouse	PMID:18614015
Cellular Component	GO:0005634	nucleus	MTCH2	HDA		Human	PMID:21630459
Biological Process	GO:0060612	adipose tissue development	mtch2	IMP		Zfish	PMID:27468124|ZFIN:ZDB-PUB-160729-2
Biological Process	GO:0071478	cellular response to radiation	Mtch2	IMP	MGI:MGI:2449949,MGI:MGI:5566664	Mouse	PMID:26219591
Biological Process	GO:0048565	digestive tract development	mtch2	IMP	ZFIN:ZDB-MRPHLNO-170109-4	Zfish	PMID:27468124
Biological Process	GO:0048565	digestive tract development	mtch2	IMP	ZFIN:ZDB-MRPHLNO-170109-3	Zfish	PMID:27468124
Biological Process	GO:0090152	establishment of protein localization to mitochondrial membrane involved in mitochondrial fission	Mtch2	IMP	MGI:MGI:2449949,MGI:MGI:5566664	Mouse	PMID:26219591
Biological Process	GO:0045444	fat cell differentiation	mtch2	IMP	ZFIN:ZDB-MRPHLNO-170109-3	Zfish	PMID:27468124
Biological Process	GO:0045444	fat cell differentiation	mtch2	IMP	ZFIN:ZDB-MRPHLNO-170109-4	Zfish	PMID:27468124
Biological Process	GO:0061484	hematopoietic stem cell homeostasis	Mtch2	IMP	MGI:MGI:2449949,MGI:MGI:5566664	Mouse	PMID:26219591
Biological Process	GO:0035701	hematopoietic stem cell migration	Mtch2	IMP	MGI:MGI:2449949,MGI:MGI:5566664	Mouse	PMID:26219591
Biological Process	GO:0097284	hepatocyte apoptotic process	Mtch2	IGI	MGI:MGI:95484	Mouse	PMID:20436477
Biological Process	GO:0097284	hepatocyte apoptotic process	Mtch2	IGI	MGI:MGI:108093	Mouse	PMID:20436477
Biological Process	GO:0006089	lactate metabolic process	Mtch2	IMP	MGI:MGI:2449949,MGI:MGI:5566664	Mouse	PMID:26219591
Biological Process	GO:0055088	lipid homeostasis	Mtch2	IMP		Mouse	MGI:MGI:6814710|PMID:28127879
Biological Process	GO:0001889	liver development	mtch2	IMP	ZFIN:ZDB-MRPHLNO-170109-3	Zfish	PMID:27468124
Biological Process	GO:0001889	liver development	mtch2	IMP	ZFIN:ZDB-MRPHLNO-170109-4	Zfish	PMID:27468124
Biological Process	GO:0042775	mitochondrial ATP synthesis coupled electron transport	Mtch2	IMP	MGI:MGI:2449949,MGI:MGI:5566664	Mouse	PMID:26219591
Biological Process	GO:0045820	negative regulation of glycolytic process	Mtch2	IMP	MGI:MGI:2449949,MGI:MGI:5566664	Mouse	PMID:26219591
Biological Process	GO:0010917	negative regulation of mitochondrial membrane potential	Mtch2	IMP	MGI:MGI:2449949,MGI:MGI:5566664	Mouse	PMID:26219591
Biological Process	GO:0043065	positive regulation of apoptotic process	Mtch2	IMP		Mouse	MGI:MGI:3581108|PMID:15899861
Biological Process	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	Mtch2	IMP	MGI:MGI:2449949,MGI:MGI:5566664	Mouse	PMID:26219591
Biological Process	GO:1902231	positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage	Mtch2	IMP	MGI:MGI:2449949,MGI:MGI:5566664	Mouse	PMID:26219591
Biological Process	GO:2000738	positive regulation of stem cell differentiation	Mtch2	IMP		Mouse	MGI:MGI:6267820|PMID:30510213
Biological Process	GO:0045040	protein insertion into mitochondrial outer membrane	MTCH2	IDA		Human	PMID:36264797
Biological Process	GO:0070585	protein localization to mitochondrion	MTCH2	IMP		Human	PMID:23744079
Biological Process	GO:0070585	protein localization to mitochondrion	Mtch2	IMP	MGI:MGI:5566665	Mouse	PMID:20436477
Biological Process	GO:0070585	protein localization to mitochondrion	Mtch2	IMP	MGI:MGI:2449949,MGI:MGI:5566664	Mouse	PMID:26219591
Biological Process	GO:0070585	protein localization to mitochondrion	Mtch2	IMP		Mouse	PMID:23744079
Biological Process	GO:0010635	regulation of mitochondrial fusion	Mtch2	IMP		Mouse	MGI:MGI:6267820|PMID:30510213
Biological Process	GO:1902108	regulation of mitochondrial membrane permeability involved in apoptotic process	Mtch2	IGI	MGI:MGI:108093	Mouse	PMID:23744079
Biological Process	GO:1902108	regulation of mitochondrial membrane permeability involved in apoptotic process	Mtch2	IGI	MGI:MGI:99702	Mouse	PMID:23744079
Biological Process	GO:1902108	regulation of mitochondrial membrane permeability involved in apoptotic process	Mtch2	IGI	MGI:MGI:108093	Mouse	PMID:20436477

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern