Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MTDH
  • Mouse genes Mtdh
  • Rat genes Mtdh
  • Zfish genes mtdha,mtdhb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Mtdh

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003725	double-stranded RNA binding	MTDH	IDA		Human	PMID:21266579
Molecular Function	GO:0051059	NF-kappaB binding	MTDH	IPI	UniProtKB:Q04206	Human	PMID:16452207
Molecular Function	GO:0005515	protein binding	MTDH	IPI	UniProtKB:Q92793	Human	PMID:18316612
Molecular Function	GO:0005515	protein binding	MTDH	IPI	UniProtKB:Q9P287	Human	PMID:18440304
Molecular Function	GO:0005515	protein binding	MTDH	IPI	UniProtKB:Q9CYH6	Human	PMID:19433866
Molecular Function	GO:0005515	protein binding	MTDH	IPI	UniProtKB:Q05516	Human	PMID:19648967
Molecular Function	GO:0005515	protein binding	MTDH	IPI	UniProtKB:Q7KZF4	Human	PMID:24981741
Molecular Function	GO:0005515	protein binding	MTDH	IPI	UniProtKB:Q9UKV8	Human	PMID:24981741
Molecular Function	GO:0005515	protein binding	MTDH	IPI	UniProtKB:Q7KZF4	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	MTDH	IPI	UniProtKB:Q7KZF4	Human	PMID:34591612
Molecular Function	GO:0005515	protein binding	Mtdh	IPI	UniProtKB:Q9CYH6	Mouse	MGI:MGI:4352957|PMID:19433866
Molecular Function	GO:0005515	protein binding	Mtdh	IPI	UniProtKB:Q78PY7	Mouse	MGI:MGI:5588616|PMID:24981741
Molecular Function	GO:0003723	RNA binding	MTDH	HDA		Human	PMID:22658674
Molecular Function	GO:0003723	RNA binding	MTDH	HDA		Human	PMID:22681889
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	MTDH	IPI	UniProtKB:P16220	Human	PMID:18316612
Molecular Function	GO:0003713	transcription coactivator activity	MTDH	IMP		Human	PMID:18316612
Cellular Component	GO:0016324	apical plasma membrane	Mtdh	IDA		Rat	PMID:15383321|RGD:1359738
Cellular Component	GO:0005923	bicellular tight junction	Mtdh	IDA		Rat	PMID:15383321|RGD:1359738
Cellular Component	GO:0005737	cytoplasm	MTDH	IDA		Human	PMID:19648967
Cellular Component	GO:0005783	endoplasmic reticulum	MTDH	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005783	endoplasmic reticulum	MTDH	IDA		Human	PMID:14980505
Cellular Component	GO:0005783	endoplasmic reticulum	MTDH	IDA		Human	PMID:15927426
Cellular Component	GO:0005783	endoplasmic reticulum	Mtdh	IDA		Mouse	MGI:MGI:3032820|PMID:14980505
Cellular Component	GO:0005789	endoplasmic reticulum membrane	Mtdh	IDA		Mouse	MGI:MGI:4352957|PMID:19433866
Cellular Component	GO:0001650	fibrillar center	MTDH	IDA		Human	GO_REF:0000052
Cellular Component	GO:0046581	intercellular canaliculus	Mtdh	IDA		Rat	PMID:15383321|RGD:1359738
Cellular Component	GO:0016604	nuclear body	MTDH	IDA		Human	PMID:19648967
Cellular Component	GO:0005730	nucleolus	Mtdh	IDA		Mouse	MGI:MGI:3032820|PMID:14980505
Cellular Component	GO:0005730	nucleolus	Mtdh	IDA		Mouse	MGI:MGI:4352957|PMID:19433866
Cellular Component	GO:0005634	nucleus	MTDH	IDA		Human	PMID:16452207
Cellular Component	GO:0048471	perinuclear region of cytoplasm	MTDH	IDA		Human	PMID:14980505
Cellular Component	GO:0048471	perinuclear region of cytoplasm	MTDH	IDA		Human	PMID:15927426
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Mtdh	IDA		Mouse	MGI:MGI:3032820|PMID:14980505
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Mtdh	IDA		Rat	PMID:15383321|RGD:1359738
Biological Process	GO:0070830	bicellular tight junction assembly	Mtdh	IEP		Rat	PMID:15383321|RGD:1359738
Biological Process	GO:0031663	lipopolysaccharide-mediated signaling pathway	MTDH	IMP		Human	PMID:19740331
Biological Process	GO:0043066	negative regulation of apoptotic process	MTDH	IDA		Human	PMID:17704808
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	MTDH	IDA		Human	PMID:15927426
Biological Process	GO:0045766	positive regulation of angiogenesis	MTDH	IDA		Human	PMID:19940250
Biological Process	GO:0010508	positive regulation of autophagy	MTDH	IDA		Human	PMID:21127263
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	MTDH	IDA		Human	PMID:16452207
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	MTDH	IDA		Human	PMID:18316612
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	MTDH	IDA		Human	PMID:16452207
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	MTDH	IDA		Human	PMID:18316612
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	MTDH	IDA		Human	PMID:17704808

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern