Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MTHFD2
  • Mouse genes Mthfd2
  • Rat genes Mthfd2
  • Zfish genes mthfd2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Mthfd2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0000287	magnesium ion binding	MTHFD2	IMP		Human	PMID:16100107
Molecular Function	GO:0000287	magnesium ion binding	MTHFD2	IDA		Human	PMID:8218174
Molecular Function	GO:0004477	methenyltetrahydrofolate cyclohydrolase activity	MTHFD2	IDA		Human	PMID:16100107
Molecular Function	GO:0004477	methenyltetrahydrofolate cyclohydrolase activity	Mthfd2	IDA		Mouse	MGI:MGI:58125|PMID:2647744
Molecular Function	GO:0004487	methylenetetrahydrofolate dehydrogenase (NAD+) activity	MTHFD2	IMP		Human	PMID:16100107
Molecular Function	GO:0004487	methylenetetrahydrofolate dehydrogenase (NAD+) activity	MTHFD2	IDA		Human	PMID:8218174
Molecular Function	GO:0004487	methylenetetrahydrofolate dehydrogenase (NAD+) activity	Mthfd2	IDA		Mouse	MGI:MGI:58125|PMID:2647744
Molecular Function	GO:0004488	methylenetetrahydrofolate dehydrogenase (NADP+) activity	MTHFD2	IMP		Human	PMID:16100107
Molecular Function	GO:0004488	methylenetetrahydrofolate dehydrogenase (NADP+) activity	MTHFD2	IDA		Human	PMID:8218174
Molecular Function	GO:0004488	methylenetetrahydrofolate dehydrogenase (NADP+) activity	Mthfd2	IDA		Mouse	MGI:MGI:58125|PMID:2647744
Molecular Function	GO:0042301	phosphate ion binding	MTHFD2	IMP		Human	PMID:16100107
Molecular Function	GO:0042301	phosphate ion binding	MTHFD2	IDA		Human	PMID:8218174
Molecular Function	GO:0005515	protein binding	MTHFD2	IPI	UniProtKB:Q9UJ70-2	Human	PMID:32296183
Cellular Component	GO:0005615	extracellular space	MTHFD2	HDA		Human	PMID:22664934
Cellular Component	GO:0005739	mitochondrion	MTHFD2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005739	mitochondrion	Mthfd2	HDA		Mouse	PMID:14651853
Cellular Component	GO:0005739	mitochondrion	Mthfd2	HDA		Mouse	PMID:18614015
Biological Process	GO:0046653	tetrahydrofolate metabolic process	MTHFD2	IDA		Human	PMID:8218174

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern