Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MTM1
  • Mouse genes Mtm1
  • Rat genes Mtm1
  • Zfish genes mtm1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Mtm1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0019215	intermediate filament binding	MTM1	IDA		Human	PMID:21135508
Molecular Function	GO:0035091	phosphatidylinositol binding	MTM1	IDA		Human	PMID:14722070
Molecular Function	GO:0052629	phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity	MTM1	IDA		Human	PMID:12646134
Molecular Function	GO:0004438	phosphatidylinositol-3-phosphate phosphatase activity	MTM1	IDA		Human	PMID:10900271
Molecular Function	GO:0004721	phosphoprotein phosphatase activity	MTM1	IDA		Human	PMID:9537414
Molecular Function	GO:0005515	protein binding	MTM1	IPI	UniProtKB:Q9C0I1	Human	PMID:12847286
Molecular Function	GO:0005515	protein binding	MTM1	IPI	UniProtKB:P17661	Human	PMID:21135508
Molecular Function	GO:0005515	protein binding	MTM1	IPI	UniProtKB:P31001	Human	PMID:21135508
Molecular Function	GO:0005515	protein binding	MTM1	IPI	UniProtKB:O00499	Human	PMID:23917616
Molecular Function	GO:0005515	protein binding	MTM1	IPI	UniProtKB:O70172	Human	PMID:26760201
Molecular Function	GO:0005515	protein binding	MTM1	IPI	UniProtKB:Q96A65	Human	PMID:26760201
Molecular Function	GO:0005515	protein binding	Mtm1	IPI	UniProtKB:P31001	Mouse	MGI:MGI:5000185|PMID:21135508
Molecular Function	GO:0005515	protein binding	Mtm1	IPI	UniProtKB:O08539	Mouse	MGI:MGI:5528957|PMID:23917616
Cellular Component	GO:0005737	cytoplasm	MTM1	IDA		Human	PMID:10900271
Cellular Component	GO:0005737	cytoplasm	MTM1	IDA		Human	PMID:12118066
Cellular Component	GO:0005737	cytoplasm	MTM1	IDA		Human	PMID:12217958
Cellular Component	GO:0005737	cytoplasm	Mtm1	IDA		Mouse	MGI:MGI:5284818|PMID:12118066
Cellular Component	GO:0005829	cytosol	MTM1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0030175	filopodium	MTM1	IDA		Human	PMID:12118066
Cellular Component	GO:0031674	I band	Mtm1	IDA		Mouse	PMID:18434328
Cellular Component	GO:0005770	late endosome	MTM1	IDA		Human	PMID:14722070
Cellular Component	GO:0005886	plasma membrane	MTM1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	MTM1	IDA		Human	PMID:12118066
Cellular Component	GO:0005886	plasma membrane	MTM1	IDA		Human	PMID:12217958
Cellular Component	GO:0005886	plasma membrane	MTM1	IDA		Human	PMID:12847286
Cellular Component	GO:0001726	ruffle	MTM1	IDA		Human	PMID:12118066
Biological Process	GO:0000045	autophagosome assembly	Mtm1	IMP	MGI:MGI:2450997	Mouse	PMID:23695157
Biological Process	GO:0043009	chordate embryonic development	mtm1	IGI	ZFIN:ZDB-MRPHLNO-100325-3,ZFIN:ZDB-MRPHLNO-100613-1	Zfish	PMID:20400459
Biological Process	GO:0008333	endosome to lysosome transport	MTM1	IDA		Human	PMID:14722070
Biological Process	GO:0045109	intermediate filament organization	MTM1	IMP		Human	PMID:21135508
Biological Process	GO:0007626	locomotory behavior	mtm1	IMP	ZFIN:ZDB-MRPHLNO-130910-6	Zfish	PMID:23818870
Biological Process	GO:0048311	mitochondrion distribution	MTM1	IMP		Human	PMID:21135508
Biological Process	GO:0048311	mitochondrion distribution	Mtm1	IMP		Mouse	MGI:MGI:5000185|PMID:21135508
Biological Process	GO:0048311	mitochondrion distribution	Mtm1	IMP	MGI:MGI:2450992	Mouse	PMID:18434328
Biological Process	GO:0070584	mitochondrion morphogenesis	MTM1	IDA		Human	PMID:21135508
Biological Process	GO:0070584	mitochondrion morphogenesis	Mtm1	IMP		Mouse	MGI:MGI:5000185|PMID:21135508
Biological Process	GO:0046716	muscle cell cellular homeostasis	Mtm1	IMP		Mouse	MGI:MGI:5475392|PMID:23390130
Biological Process	GO:0046716	muscle cell cellular homeostasis	Mtm1	IMP	MGI:MGI:2450992	Mouse	PMID:12391329
Biological Process	GO:0046716	muscle cell cellular homeostasis	mtm1	IGI	ZFIN:ZDB-MRPHLNO-100325-3,ZFIN:ZDB-MRPHLNO-100613-1	Zfish	PMID:20400459
Biological Process	GO:1902902	negative regulation of autophagosome assembly	Mtm1	IMP	MGI:MGI:2450997	Mouse	PMID:23695157
Biological Process	GO:0032435	negative regulation of proteasomal ubiquitin-dependent protein catabolic process	Mtm1	IMP	MGI:MGI:2450997	Mouse	PMID:23695157
Biological Process	GO:0051898	negative regulation of protein kinase B signaling	Mtm1	IMP	MGI:MGI:2450997	Mouse	PMID:23695157
Biological Process	GO:0032007	negative regulation of TOR signaling	Mtm1	IMP	MGI:MGI:2450997	Mouse	PMID:23695157
Biological Process	GO:0007528	neuromuscular junction development	mtm1	IMP	ZFIN:ZDB-MRPHLNO-100325-1	Zfish	PMID:21440438
Biological Process	GO:0046856	phosphatidylinositol dephosphorylation	MTM1	IDA		Human	PMID:10900271
Biological Process	GO:0046856	phosphatidylinositol dephosphorylation	MTM1	IDA		Human	PMID:12646134
Biological Process	GO:0048633	positive regulation of skeletal muscle tissue growth	Mtm1	IMP	MGI:MGI:2450997	Mouse	PMID:23695157
Biological Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Mtm1	IMP	MGI:MGI:2450997	Mouse	PMID:23695157
Biological Process	GO:0006470	protein dephosphorylation	MTM1	IDA		Human	PMID:9537414
Biological Process	GO:0043491	protein kinase B signaling	Mtm1	IMP	MGI:MGI:2450997	Mouse	PMID:23695157
Biological Process	GO:0010506	regulation of autophagy	mtm1	IGI	ZFIN:ZDB-MRPHLNO-100325-3,ZFIN:ZDB-MRPHLNO-100613-1	Zfish	PMID:20400459
Biological Process	GO:0044088	regulation of vacuole organization	MTM1	IDA		Human	PMID:14722070
Biological Process	GO:0048741	skeletal muscle fiber development	mtm1	IMP	ZFIN:ZDB-MRPHLNO-100325-1	Zfish	PMID:19197364
Biological Process	GO:0048741	skeletal muscle fiber development	mtm1	IGI	ZFIN:ZDB-MRPHLNO-130910-6,ZFIN:ZDB-MRPHLNO-130910-8	Zfish	PMID:23818870
Biological Process	GO:0048741	skeletal muscle fiber development	mtm1	IMP	ZFIN:ZDB-MRPHLNO-100325-2	Zfish	PMID:19197364
Biological Process	GO:0048741	skeletal muscle fiber development	mtm1	IMP	ZFIN:ZDB-MRPHLNO-100325-3	Zfish	PMID:19197364
Biological Process	GO:0007519	skeletal muscle tissue development	mtm1	IMP	ZFIN:ZDB-GENO-170615-10	Zfish	PMID:27548528
Biological Process	GO:0007519	skeletal muscle tissue development	mtm1	IMP	ZFIN:ZDB-MRPHLNO-100325-3	Zfish	PMID:27548528
Biological Process	GO:0048630	skeletal muscle tissue growth	Mtm1	IMP	MGI:MGI:2450997	Mouse	PMID:23695157
Biological Process	GO:0007525	somatic muscle development	mtm1	IMP	ZFIN:ZDB-MRPHLNO-130910-6	Zfish	PMID:24378748
Biological Process	GO:0031929	TOR signaling	Mtm1	IMP	MGI:MGI:2450997	Mouse	PMID:23695157

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern