Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MTNR1A
  • Mouse genes Mtnr1a
  • Rat genes Mtnr1a
  • Zfish genes mtnr1aa,mtnr1ab
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Mtnr1a

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042562	hormone binding	MTNR1A	IPI	CHEBI:16796	Human	PMID:10531408
Molecular Function	GO:0008502	melatonin receptor activity	MTNR1A	IDA		Human	PMID:10531408
Molecular Function	GO:0097159	organic cyclic compound binding	MTNR1A	IPI	CHEBI:16796	Human	PMID:10531408
Molecular Function	GO:0005515	protein binding	MTNR1A	IPI	UniProtKB:P27797	Human	PMID:17215244
Molecular Function	GO:0005515	protein binding	MTNR1A	IPI	UniProtKB:P57088	Human	PMID:17215244
Molecular Function	GO:0005515	protein binding	MTNR1A	IPI	UniProtKB:O76081	Human	PMID:20859254
Molecular Function	GO:0005515	protein binding	MTNR1A	IPI	UniProtKB:P49286	Human	PMID:20859254
Molecular Function	GO:0005515	protein binding	MTNR1A	IPI	UniProtKB:P27797	Human	PMID:26514267
Molecular Function	GO:0005515	protein binding	MTNR1A	IPI	UniProtKB:P57088	Human	PMID:26514267
Molecular Function	GO:0005515	protein binding	MTNR1A	IPI	UniProtKB:P27797	Human	PMID:28298427
Molecular Function	GO:0005515	protein binding	MTNR1A	IPI	UniProtKB:P57088	Human	PMID:28298427
Molecular Function	GO:0005515	protein binding	MTNR1A	IPI	UniProtKB:A8MQ03	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MTNR1A	IPI	UniProtKB:Q8IUG1	Human	PMID:32296183
Cellular Component	GO:0043025	neuronal cell body	Mtnr1a	IDA		Rat	PMID:10465462|RGD:9686054
Cellular Component	GO:0005886	plasma membrane	MTNR1A	IDA		Human	PMID:10531408
Cellular Component	GO:0043235	receptor complex	MTNR1A	IDA		Human	PMID:10531408
Biological Process	GO:0007193	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	MTNR1A	IDA		Human	PMID:10531408
Biological Process	GO:0007568	aging	Mtnr1a	IEP		Rat	PMID:23895529|RGD:9686056
Biological Process	GO:0043010	camera-type eye development	Mtnr1a	IEP		Rat	PMID:12890503|RGD:9588674
Biological Process	GO:0007623	circadian rhythm	Mtnr1a	IEP		Rat	PMID:23895529|RGD:9686056
Biological Process	GO:0046676	negative regulation of insulin secretion	Mtnr1a	IMP		Rat	PMID:22288848|RGD:9686057

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern