Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MTRR
  • Mouse genes Mtrr
  • Rat genes Mtrr
  • Zfish genes mtrr
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Mtrr

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0030586	[methionine synthase] reductase activity	MTRR	IDA		Human	PMID:11466310
Molecular Function	GO:0030586	[methionine synthase] reductase activity	MTRR	IDA		Human	PMID:9501215
Molecular Function	GO:0030586	[methionine synthase] reductase activity	Mtrr	IMP		Mouse	PMID:17369066
Molecular Function	GO:0071949	FAD binding	MTRR	IDA		Human	PMID:11466310
Molecular Function	GO:0050660	flavin adenine dinucleotide binding	MTRR	IDA		Human	PMID:17892308
Molecular Function	GO:0010181	FMN binding	MTRR	IDA		Human	PMID:11466310
Molecular Function	GO:0070402	NADPH binding	MTRR	IDA		Human	PMID:11466310
Molecular Function	GO:0003958	NADPH-hemoprotein reductase activity	MTRR	IDA		Human	PMID:11466310
Molecular Function	GO:0016723	oxidoreductase activity, acting on metal ions, NAD or NADP as acceptor	MTRR	IDA		Human	PMID:17892308
Molecular Function	GO:0005515	protein binding	MTRR	IPI	UniProtKB:Q99707	Human	PMID:17288554
Molecular Function	GO:0005515	protein binding	MTRR	IPI	UniProtKB:Q53SE7	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	MTRR	IPI	UniProtKB:Q99707	Human	PMID:27771510
Molecular Function	GO:0005515	protein binding	MTRR	IPI	UniProtKB:Q9H3L0	Human	PMID:27771510
Molecular Function	GO:0005515	protein binding	MTRR	IPI	UniProtKB:Q9Y4U1	Human	PMID:27771510
Cellular Component	GO:0005829	cytosol	MTRR	IDA		Human	PMID:18221906
Cellular Component	GO:0005829	cytosol	MTRR	IDA		Human	GO_REF:0000052
Cellular Component	GO:0045111	intermediate filament cytoskeleton	MTRR	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	MTRR	IDA		Human	GO_REF:0000052
Biological Process	GO:0009235	cobalamin metabolic process	Mtrr	IMP		Mouse	PMID:17369066
Biological Process	GO:0006306	DNA methylation	Mtrr	IMP		Mouse	MGI:MGI:5512657|PMID:24074862
Biological Process	GO:0046655	folic acid metabolic process	MTRR	IDA		Human	PMID:11466310
Biological Process	GO:0046655	folic acid metabolic process	Mtrr	IMP		Mouse	MGI:MGI:5512657|PMID:24074862
Biological Process	GO:0043418	homocysteine catabolic process	MTRR	IDA		Human	PMID:11466310
Biological Process	GO:0050667	homocysteine metabolic process	Mtrr	IMP		Mouse	MGI:MGI:3710265|PMID:17369066
Biological Process	GO:0009086	methionine biosynthetic process	MTRR	IDA		Human	PMID:11466310
Biological Process	GO:0009086	methionine biosynthetic process	Mtrr	IMP		Mouse	MGI:MGI:3710265|PMID:17369066
Biological Process	GO:1904042	negative regulation of cystathionine beta-synthase activity	MTRR	IDA		Human	PMID:24416422
Biological Process	GO:0033353	S-adenosylmethionine cycle	Mtrr	IMP		Mouse	MGI:MGI:3710265|PMID:17369066

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern