Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MUC1
  • Mouse genes Muc1
  • Rat genes Muc1
  • Zfish genes si:dkeyp-92c9.4
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Muc1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0002039	p53 binding	MUC1	IPI	UniProtKB:P04637	Human	PMID:15710329
Molecular Function	GO:0005515	protein binding	MUC1	IPI	UniProtKB:P00519	Human	PMID:16888623
Molecular Function	GO:0005515	protein binding	MUC1	IPI	UniProtKB:P00533	Human	PMID:21258405
Molecular Function	GO:0005515	protein binding	MUC1	IPI	UniProtKB:P15941-7	Human	PMID:21798038
Molecular Function	GO:0005515	protein binding	MUC1	IPI	UniProtKB:P08581	Human	PMID:22962849
Molecular Function	GO:0005515	protein binding	MUC1	IPI	UniProtKB:P00533	Human	PMID:24658140
Molecular Function	GO:0005515	protein binding	MUC1	IPI	UniProtKB:P00533	Human	PMID:31980649
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	MUC1	IDA		Human	PMID:15710329
Molecular Function	GO:0003712	transcription coregulator activity	MUC1	IDA		Human	PMID:15710329
Cellular Component	GO:0016324	apical plasma membrane	Muc1	IDA		Mouse	PMID:16472605
Cellular Component	GO:0016324	apical plasma membrane	Muc1	IDA		Rat	PMID:19549898|RGD:2317979
Cellular Component	GO:0009986	cell surface	Muc1	IDA		Mouse	PMID:1569123
Cellular Component	GO:0000785	chromatin	MUC1	IDA		Human	PMID:15710329
Cellular Component	GO:0062023	collagen-containing extracellular matrix	Muc1	HDA		Mouse	MGI:MGI:6201853|PMID:28071719
Cellular Component	GO:0005737	cytoplasm	Muc1	IDA		Rat	PMID:19549898|RGD:2317979
Cellular Component	GO:0070062	extracellular exosome	MUC1	IDA		Human	PMID:15326289
Cellular Component	GO:0070062	extracellular exosome	MUC1	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	MUC1	HDA		Human	PMID:19199708
Cellular Component	GO:0070062	extracellular exosome	MUC1	HDA		Human	PMID:23533145
Cellular Component	GO:0005615	extracellular space	MUC1	HDA		Human	PMID:16502470
Cellular Component	GO:0005886	plasma membrane	MUC1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	Muc1	IDA		Rat	PMID:13677617|RGD:2308909
Cellular Component	GO:0031982	vesicle	MUC1	HDA		Human	PMID:19190083
Biological Process	GO:0071300	cellular response to retinoic acid	Muc1	IEP		Rat	PMID:8967520|RGD:633461
Biological Process	GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	MUC1	IDA		Human	PMID:15710329
Biological Process	GO:0006978	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	MUC1	IDA		Human	PMID:15710329
Biological Process	GO:0030855	epithelial cell differentiation	Muc1	IEP		Rat	PMID:8967520|RGD:633461
Biological Process	GO:0007565	female pregnancy	Muc1	IEP		Rat	PMID:13677617|RGD:2308909
Biological Process	GO:0001701	in utero embryonic development	Muc1	IEP		Rat	PMID:21263748|RGD:7349384
Biological Process	GO:0051179	localization	MUC1	IDA		Human	PMID:26267657
Biological Process	GO:0033629	negative regulation of cell adhesion mediated by integrin	MUC1	IDA		Human	PMID:7698991
Biological Process	GO:1902166	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	MUC1	IDA		Human	PMID:15710329
Biological Process	GO:0010944	negative regulation of transcription by competitive promoter binding	MUC1	IDA		Human	PMID:15710329
Biological Process	GO:0090240	positive regulation of histone H4 acetylation	MUC1	IDA		Human	PMID:15710329
Biological Process	GO:0036003	positive regulation of transcription from RNA polymerase II promoter in response to stress	MUC1	IDA		Human	PMID:15710329
Biological Process	GO:0043618	regulation of transcription from RNA polymerase II promoter in response to stress	MUC1	IDA		Human	PMID:15710329
Biological Process	GO:0001666	response to hypoxia	Muc1	IEP		Rat	PMID:19549898|RGD:2317979

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern