Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MUC2
  • Mouse genes Muc2
  • Rat genes Muc2
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Muc2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:1903135	cupric ion binding	MUC2	IDA		Human	PMID:36206754
Molecular Function	GO:1903136	cuprous ion binding	MUC2	IDA		Human	PMID:36206754
Molecular Function	GO:0005201	extracellular matrix structural constituent	Muc2	IDA		Mouse	PMID:35337837
Molecular Function	GO:0042802	identical protein binding	Muc2	IMP		Rat	PMID:12744721|RGD:724404
Molecular Function	GO:0005515	protein binding	MUC2	IPI	UniProtKB:O95994	Human	PMID:19359471
Molecular Function	GO:0005515	protein binding	MUC2	IPI	UniProtKB:Q9Y6R7	Human	PMID:19432394
Molecular Function	GO:0005515	protein binding	Muc2	IPI	UniProtKB:Q8K0P6	Mouse	MGI:MGI:3851664|PMID:19432394
Molecular Function	GO:0005515	protein binding	Muc2	IPI	MGI:MGI:2444336	Mouse	PMID:19411636
Molecular Function	GO:0005515	protein binding	Muc2	IPI	RGD:3847	Rat	PMID:21629776|RGD:7349366
Cellular Component	GO:0062023	collagen-containing extracellular matrix	MUC2	HDA		Human	PMID:25037231
Cellular Component	GO:0062023	collagen-containing extracellular matrix	Muc2	HDA		Mouse	MGI:MGI:6201834|PMID:22159717
Cellular Component	GO:0005737	cytoplasm	Muc2	IDA		Rat	PMID:17417665|RGD:2324678
Cellular Component	GO:0031012	extracellular matrix	Muc2	IDA		Mouse	PMID:19411636
Cellular Component	GO:0031012	extracellular matrix	Muc2	IDA		Mouse	PMID:11352827
Cellular Component	GO:0070702	inner mucus layer	Muc2	IDA		Mouse	MGI:MGI:3822258|PMID:18806221
Cellular Component	GO:0070702	inner mucus layer	Muc2	IDA		Mouse	MGI:MGI:3851664|PMID:19432394
Cellular Component	GO:0070701	mucus layer	Muc2	IDA		Mouse	PMID:35337837
Cellular Component	GO:0070701	mucus layer	Muc2	IDA		Rat	PMID:21629776|RGD:7349366
Cellular Component	GO:0005634	nucleus	Muc2	IDA		Rat	PMID:17417665|RGD:2324678
Cellular Component	GO:0070703	outer mucus layer	Muc2	IDA		Mouse	MGI:MGI:6471838|PMID:33093110
Cellular Component	GO:0070703	outer mucus layer	Muc2	IDA		Mouse	MGI:MGI:3851664|PMID:19432394
Cellular Component	GO:0070703	outer mucus layer	Muc2	IDA		Mouse	MGI:MGI:3822258|PMID:18806221
Biological Process	GO:0006915	apoptotic process	Muc2	IMP	MGI:MGI:2183923	Mouse	PMID:11872843
Biological Process	GO:0071356	cellular response to tumor necrosis factor	Muc2	IEP		Rat	PMID:18507686|RGD:2324885
Biological Process	GO:0010273	detoxification of copper ion	MUC2	IDA		Human	PMID:36206754
Biological Process	GO:0002068	glandular epithelial cell development	Muc2	IMP	MGI:MGI:2183923	Mouse	PMID:11872843
Biological Process	GO:0048874	host-mediated regulation of intestinal microbiota composition	Muc2	IDA		Mouse	MGI:MGI:6471838|PMID:33093110
Biological Process	GO:0030277	maintenance of gastrointestinal epithelium	MUC2	IMP		Human	PMID:17058067
Biological Process	GO:0030277	maintenance of gastrointestinal epithelium	Muc2	IDA		Mouse	MGI:MGI:6471838|PMID:33093110
Biological Process	GO:0030277	maintenance of gastrointestinal epithelium	Muc2	IDA		Mouse	PMID:35337837
Biological Process	GO:0070254	mucus secretion	MUC2	IMP		Human	PMID:17058067
Biological Process	GO:0070254	mucus secretion	Muc2	IDA		Mouse	PMID:35337837
Biological Process	GO:0030336	negative regulation of cell migration	Muc2	IMP	MGI:MGI:2183923	Mouse	PMID:11872843
Biological Process	GO:0008285	negative regulation of cell population proliferation	Muc2	IMP	MGI:MGI:2183923	Mouse	PMID:11872843
Biological Process	GO:0043065	positive regulation of apoptotic process	Muc2	IMP	MGI:MGI:2183923	Mouse	PMID:11872843
Biological Process	GO:0140459	response to Gram-positive bacterium	Muc2	IEP		Rat	PMID:20501441|RGD:2324672
Biological Process	GO:0009725	response to hormone	Muc2	IEP		Rat	PMID:17495032|RGD:2303604
Biological Process	GO:0032496	response to lipopolysaccharide	Muc2	IEP		Rat	PMID:17417665|RGD:2324678
Biological Process	GO:0071559	response to transforming growth factor beta	Muc2	IEP		Rat	PMID:15980276|RGD:8693640
Biological Process	GO:0033189	response to vitamin A	Muc2	IEP		Rat	PMID:18495461|RGD:2324677

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern