Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MUC4
  • Mouse genes Muc4
  • Rat genes Muc4
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Muc4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005176	ErbB-2 class receptor binding	Muc4	IPI	RGD:2561	Rat	PMID:15499570|RGD:1582108
Molecular Function	GO:0044877	protein-containing complex binding	Muc4	IDA		Rat	PMID:20054827|RGD:2324912
Cellular Component	GO:0016324	apical plasma membrane	Muc4	IDA		Rat	PMID:15499570|RGD:1582108
Cellular Component	GO:0062023	collagen-containing extracellular matrix	Muc4	HDA		Mouse	MGI:MGI:6201853|PMID:28071719
Cellular Component	GO:0005737	cytoplasm	Muc4	IDA		Rat	PMID:15389518|RGD:2303738
Cellular Component	GO:0005783	endoplasmic reticulum	Muc4	IDA		Rat	PMID:20054827|RGD:2324912
Cellular Component	GO:0070062	extracellular exosome	MUC4	HDA		Human	PMID:19199708
Cellular Component	GO:0070062	extracellular exosome	MUC4	HDA		Human	PMID:23533145
Cellular Component	GO:0005615	extracellular space	MUC4	HDA		Human	PMID:16502470
Cellular Component	GO:0005615	extracellular space	Muc4	IDA		Rat	PMID:12186632|RGD:2303742
Cellular Component	GO:0031528	microvillus membrane	Muc4	IDA		Rat	PMID:2674161|RGD:2303756
Cellular Component	GO:0032991	protein-containing complex	Muc4	IDA		Rat	PMID:20054827|RGD:2324912
Cellular Component	GO:0031982	vesicle	MUC4	HDA		Human	PMID:19190083
Biological Process	GO:0032869	cellular response to insulin stimulus	Muc4	IEP		Rat	PMID:10980611|RGD:2303745
Biological Process	GO:0071560	cellular response to transforming growth factor beta stimulus	Muc4	IEP		Rat	PMID:9857062|RGD:2324952
Biological Process	GO:0048565	digestive tract development	Muc4	IEP		Rat	PMID:15389518|RGD:2303738
Biological Process	GO:0044849	estrous cycle	Muc4	IEP		Rat	PMID:9618151|RGD:2303752
Biological Process	GO:0002244	hematopoietic progenitor cell differentiation	Muc4	IMP		Mouse	PMID:24029230
Biological Process	GO:0007595	lactation	Muc4	IEP		Rat	PMID:15499570|RGD:1582108
Biological Process	GO:0030277	maintenance of gastrointestinal epithelium	MUC4	IMP		Human	PMID:17058067
Biological Process	GO:0030879	mammary gland development	Muc4	IEP		Rat	PMID:15499570|RGD:1582108
Biological Process	GO:0043066	negative regulation of apoptotic process	Muc4	IDA		Rat	PMID:19293191|RGD:7349401
Biological Process	GO:0022408	negative regulation of cell-cell adhesion	Muc4	IDA		Rat	PMID:9407114|RGD:2303753
Biological Process	GO:0001953	negative regulation of cell-matrix adhesion	Muc4	IDA		Rat	PMID:9407114|RGD:2303753
Biological Process	GO:0002853	negative regulation of T cell mediated cytotoxicity directed against tumor cell target	Muc4	IDA		Rat	PMID:10232613|RGD:2303754
Biological Process	GO:0031077	post-embryonic camera-type eye development	Muc4	IEP		Rat	PMID:11120573|RGD:2303744
Biological Process	GO:0010469	regulation of signaling receptor activity	Muc4	IDA		Rat	PMID:10026131|RGD:2303749
Biological Process	GO:0046677	response to antibiotic	Muc4	IEP		Rat	PMID:2386935|RGD:2303755
Biological Process	GO:0034097	response to cytokine	Muc4	IEP		Rat	PMID:12668667|RGD:2303741
Biological Process	GO:0032355	response to estradiol	Muc4	IEP		Rat	PMID:9618151|RGD:2303752
Biological Process	GO:0009725	response to hormone	Muc4	IEP		Rat	PMID:17495032|RGD:2303604
Biological Process	GO:0032570	response to progesterone	Muc4	IEP		Rat	PMID:9618151|RGD:2303752
Biological Process	GO:0033189	response to vitamin A	Muc4	IEP		Rat	PMID:10634605|RGD:2303747
Biological Process	GO:0009410	response to xenobiotic stimulus	Muc4	IEP		Rat	PMID:18998135|RGD:2303603

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern