Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MUL1
  • Mouse genes Mul1
  • Rat genes Mul1
  • Zfish genes mul1a,mul1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Mul1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042802	identical protein binding	MUL1	IPI	UniProtKB:Q969V5	Human	PMID:18591963
Molecular Function	GO:0002039	p53 binding	MUL1	IPI	UniProtKB:P04637	Human	PMID:21597459
Molecular Function	GO:0005515	protein binding	MUL1	IPI	UniProtKB:Q92624	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	MUL1	IPI	UniProtKB:O43318	Human	PMID:18591963
Molecular Function	GO:0005515	protein binding	MUL1	IPI	UniProtKB:Q92624	Human	PMID:19060904
Molecular Function	GO:0005515	protein binding	MUL1	IPI	UniProtKB:O00429	Human	PMID:19407830
Molecular Function	GO:0005515	protein binding	MUL1	IPI	UniProtKB:Q7Z434	Human	PMID:23399697
Molecular Function	GO:0005515	protein binding	MUL1	IPI	UniProtKB:Q9C026	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	MUL1	IPI	UniProtKB:P60410	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MUL1	IPI	UniProtKB:Q92624	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MUL1	IPI	UniProtKB:Q9BRK0	Human	PMID:32296183
Molecular Function	GO:0019789	SUMO transferase activity	MUL1	IDA		Human	PMID:19407830
Molecular Function	GO:0061630	ubiquitin protein ligase activity	MUL1	IDA		Human	PMID:18213395
Molecular Function	GO:0061630	ubiquitin protein ligase activity	MUL1	IDA		Human	PMID:18591963
Molecular Function	GO:0061630	ubiquitin protein ligase activity	MUL1	IDA		Human	PMID:21597459
Molecular Function	GO:0031625	ubiquitin protein ligase binding	MUL1	IPI	UniProtKB:P63279	Human	PMID:19407830
Cellular Component	GO:0030424	axon	MUL1	IMP		Human	PMID:24898855
Cellular Component	GO:0016020	membrane	MUL1	HDA		Human	PMID:19946888
Cellular Component	GO:0005741	mitochondrial outer membrane	MUL1	IDA		Human	PMID:18207745
Cellular Component	GO:0005741	mitochondrial outer membrane	MUL1	IDA		Human	PMID:18213395
Cellular Component	GO:0005739	mitochondrion	MUL1	IDA		Human	GO_REF:0000054
Cellular Component	GO:0005739	mitochondrion	MUL1	IDA		Human	PMID:21597459
Cellular Component	GO:0005739	mitochondrion	MUL1	IMP		Human	PMID:24898855
Cellular Component	GO:0005739	mitochondrion	Mul1	HDA		Mouse	PMID:18614015
Cellular Component	GO:0043025	neuronal cell body	MUL1	IMP		Human	PMID:24898855
Cellular Component	GO:0005777	peroxisome	MUL1	IDA		Human	PMID:18207745
Biological Process	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	MUL1	IDA		Human	PMID:18591963
Biological Process	GO:0071360	cellular response to exogenous dsRNA	MUL1	IDA		Human	PMID:23399697
Biological Process	GO:0000266	mitochondrial fission	MUL1	IMP		Human	PMID:18207745
Biological Process	GO:0051646	mitochondrion localization	MUL1	IMP		Human	PMID:18213395
Biological Process	GO:0030308	negative regulation of cell growth	MUL1	IDA		Human	PMID:18591963
Biological Process	GO:0071650	negative regulation of chemokine (C-C motif) ligand 5 production	MUL1	IMP		Human	PMID:23399697
Biological Process	GO:0050689	negative regulation of defense response to virus by host	MUL1	IMP		Human	PMID:23399697
Biological Process	GO:0045824	negative regulation of innate immune response	MUL1	IMP		Human	PMID:23399697
Biological Process	GO:0010637	negative regulation of mitochondrial fusion	MUL1	IDA		Human	PMID:19407830
Biological Process	GO:0051898	negative regulation of protein kinase B signaling	MUL1	IDA		Human	PMID:22410793
Biological Process	GO:0060339	negative regulation of type I interferon-mediated signaling pathway	MUL1	IMP		Human	PMID:23399697
Biological Process	GO:1904925	positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization	Mul1	IMP		Mouse	MGI:MGI:5581539|PMID:24709290
Biological Process	GO:1903861	positive regulation of dendrite extension	Mul1	IMP		Mouse	MGI:MGI:5619681|PMID:24898855
Biological Process	GO:1903861	positive regulation of dendrite extension	Mul1	IGI	UniProtKB:Q9WVS6	Mouse	MGI:MGI:5619681|PMID:24898855
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	MUL1	HMP		Human	PMID:12761501
Biological Process	GO:0090141	positive regulation of mitochondrial fission	MUL1	IDA		Human	PMID:19407830
Biological Process	GO:0033235	positive regulation of protein sumoylation	MUL1	IDA		Human	PMID:19407830
Biological Process	GO:0031648	protein destabilization	MUL1	IMP		Human	PMID:24898855
Biological Process	GO:0000209	protein polyubiquitination	MUL1	IDA		Human	PMID:21597459
Biological Process	GO:0050821	protein stabilization	MUL1	IMP		Human	PMID:19407830
Biological Process	GO:0016567	protein ubiquitination	MUL1	IDA		Human	PMID:18213395
Biological Process	GO:0051881	regulation of mitochondrial membrane potential	Mul1	IGI	UniProtKB:Q9WVS6	Mouse	MGI:MGI:5619681|PMID:24898855
Biological Process	GO:1901028	regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway	MUL1	IDA		Human	PMID:18591963
Biological Process	GO:0010821	regulation of mitochondrion organization	MUL1	IMP		Human	PMID:24898855
Biological Process	GO:0031647	regulation of protein stability	Mul1	IMP	UniProtKB:Q9WVS6	Mouse	MGI:MGI:5619681|PMID:24898855

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern