Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MVK
  • Mouse genes Mvk
  • Rat genes Mvk
  • Zfish genes mvk
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Mvk

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005524	ATP binding	Mvk	IDA		Rat	PMID:11877411|RGD:729101
Molecular Function	GO:0042802	identical protein binding	MVK	IPI	UniProtKB:Q03426	Human	PMID:16189514
Molecular Function	GO:0042802	identical protein binding	MVK	IPI	UniProtKB:Q03426	Human	PMID:25502805
Molecular Function	GO:0042802	identical protein binding	MVK	IPI	UniProtKB:Q03426	Human	PMID:26871637
Molecular Function	GO:0042802	identical protein binding	MVK	IPI	UniProtKB:Q03426	Human	PMID:31515488
Molecular Function	GO:0042802	identical protein binding	MVK	IPI	UniProtKB:Q03426	Human	PMID:32296183
Molecular Function	GO:0042802	identical protein binding	MVK	IDA		Human	PMID:9325256
Molecular Function	GO:0042802	identical protein binding	Mvk	IDA		Rat	PMID:11877411|RGD:729101
Molecular Function	GO:0000287	magnesium ion binding	Mvk	IDA		Rat	PMID:11877411|RGD:729101
Molecular Function	GO:0004496	mevalonate kinase activity	MVK	IMP		Human	PMID:10369261
Molecular Function	GO:0004496	mevalonate kinase activity	MVK	IDA		Human	PMID:1377680
Molecular Function	GO:0004496	mevalonate kinase activity	MVK	IDA		Human	PMID:14680974
Molecular Function	GO:0004496	mevalonate kinase activity	MVK	IDA		Human	PMID:14730012
Molecular Function	GO:0004496	mevalonate kinase activity	MVK	IDA		Human	PMID:18302342
Molecular Function	GO:0004496	mevalonate kinase activity	MVK	IDA		Human	PMID:9325256
Molecular Function	GO:0004496	mevalonate kinase activity	Mvk	IDA		Mouse	PMID:11792727
Molecular Function	GO:0004496	mevalonate kinase activity	Mvk	IDA		Rat	PMID:197206|RGD:2316852
Molecular Function	GO:0004496	mevalonate kinase activity	Mvk	IDA		Rat	PMID:2158094|RGD:728935
Molecular Function	GO:0004496	mevalonate kinase activity	Mvk	IDA		Rat	PMID:7904598|RGD:2316851
Molecular Function	GO:0003729	mRNA binding	Mvk	IDA		Rat	PMID:16263716|RGD:1600527
Molecular Function	GO:0005515	protein binding	MVK	IPI	UniProtKB:Q9NUX5	Human	PMID:21044950
Molecular Function	GO:0005515	protein binding	MVK	IPI	UniProtKB:Q8WVD5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Mvk	IPI	RGD:621037	Rat	PMID:20167237|RGD:11040964
Molecular Function	GO:1990825	sequence-specific mRNA binding	Mvk	IDA		Rat	PMID:14749336|RGD:12793000
Cellular Component	GO:0005737	cytoplasm	Mvk	IDA		Rat	PMID:14730012|RGD:8553267
Cellular Component	GO:0005829	cytosol	MVK	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	MVK	IDA		Human	PMID:14730012
Cellular Component	GO:0005829	cytosol	Mvk	IDA		Rat	PMID:7904598|RGD:2316851
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	MVK	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005777	peroxisome	Mvk	IDA		Rat	PMID:1312092|RGD:8553841
Cellular Component	GO:0005777	peroxisome	Mvk	IDA		Rat	PMID:17180682|RGD:8554417
Cellular Component	GO:0005777	peroxisome	Mvk	IDA		Rat	PMID:7904598|RGD:2316851
Biological Process	GO:0006695	cholesterol biosynthetic process	MVK	IDA		Human	PMID:1377680
Biological Process	GO:0019287	isopentenyl diphosphate biosynthetic process, mevalonate pathway	Mvk	IDA		Rat	PMID:197206|RGD:2316852
Biological Process	GO:0008299	isoprenoid biosynthetic process	MVK	IDA		Human	PMID:14680974
Biological Process	GO:0008299	isoprenoid biosynthetic process	MVK	IDA		Human	PMID:14730012
Biological Process	GO:0008299	isoprenoid biosynthetic process	Mvk	IDA		Rat	PMID:7904598|RGD:2316851
Biological Process	GO:0050728	negative regulation of inflammatory response	MVK	IMP		Human	PMID:16732551
Biological Process	GO:0017148	negative regulation of translation	Mvk	IDA		Rat	PMID:16263716|RGD:1600527

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern