Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MX1,MX2
  • Mouse genes Mx2
  • Rat genes Mx2
  • Zfish genes mxa,mxb,mxc,mxe,mxh
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Mx2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005525	GTP binding	MX2	IMP		Human	PMID:15184662
Molecular Function	GO:0042802	identical protein binding	MX1	IPI	UniProtKB:P20591	Human	PMID:20428112
Molecular Function	GO:0042802	identical protein binding	MX1	IPI	UniProtKB:P20591	Human	PMID:25295396
Molecular Function	GO:0042802	identical protein binding	MX1	IPI	UniProtKB:P20591	Human	PMID:25416956
Molecular Function	GO:0042802	identical protein binding	MX1	IPI	UniProtKB:P20591	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MX1	IPI	UniProtKB:P89522	Human	PMID:15047845
Molecular Function	GO:0005515	protein binding	MX1	IPI	UniProtKB:Q13507	Human	PMID:15757897
Molecular Function	GO:0005515	protein binding	MX1	IPI	UniProtKB:Q9UBN4	Human	PMID:15757897
Molecular Function	GO:0005515	protein binding	MX1	IPI	UniProtKB:Q9Y210	Human	PMID:15757897
Molecular Function	GO:0005515	protein binding	MX1	IPI	UniProtKB:O00148	Human	PMID:21859714
Molecular Function	GO:0005515	protein binding	MX1	IPI	UniProtKB:Q13838	Human	PMID:21859714
Molecular Function	GO:0005515	protein binding	MX1	IPI	UniProtKB:Q8IUQ4	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	MX1	IPI	UniProtKB:Q9H9S4	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	MX1	IPI	UniProtKB:Q08380	Human	PMID:30833792
Molecular Function	GO:0005515	protein binding	MX1	IPI	UniProtKB:O75928-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MX1	IPI	UniProtKB:P59942	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MX2	IPI	UniProtKB:A2ABF9	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	MX2	IPI	UniProtKB:O75928	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	MX2	IPI	UniProtKB:Q8WXE1	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	MX2	IPI	UniProtKB:Q96KQ7	Human	PMID:32296183
Cellular Component	GO:0005737	cytoplasm	MX1	IDA		Human	PMID:21859714
Cellular Component	GO:0005737	cytoplasm	Mx2	IDA		Rat	PMID:2173790|RGD:728936
Cellular Component	GO:0005829	cytosol	MX1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	MX1	HDA		Human	PMID:16780588
Cellular Component	GO:0031965	nuclear membrane	MX1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005643	nuclear pore	MX2	IDA		Human	PMID:15184662
Cellular Component	GO:0048471	perinuclear region of cytoplasm	MX1	IDA		Human	PMID:15047845
Biological Process	GO:0140374	antiviral innate immune response	MX1	IEP		Human	PMID:25930096
Biological Process	GO:0051607	defense response to virus	MX1	IDA		Human	PMID:21478870
Biological Process	GO:0051607	defense response to virus	MX2	IMP		Human	PMID:24121441
Biological Process	GO:0070106	interleukin-27-mediated signaling pathway	MX1	IEP		Human	PMID:32270034
Biological Process	GO:0045071	negative regulation of viral genome replication	MX1	IDA		Human	PMID:14687945
Biological Process	GO:0045071	negative regulation of viral genome replication	MX1	IDA		Human	PMID:15047845
Biological Process	GO:0045071	negative regulation of viral genome replication	MX1	IDA		Human	PMID:16202617
Biological Process	GO:0051726	regulation of cell cycle	MX2	IMP		Human	PMID:15184662
Biological Process	GO:0046822	regulation of nucleocytoplasmic transport	MX2	IMP		Human	PMID:15184662
Biological Process	GO:0046685	response to arsenic-containing substance	mxa	IDA		Zfish	PMID:16007375
Biological Process	GO:0046685	response to arsenic-containing substance	mxa	IDA		Zfish	PMID:17400579
Biological Process	GO:0009617	response to bacterium	Mx2	IEP		Mouse	PMID:23012479
Biological Process	GO:0009617	response to bacterium	mxa	IDA		Zfish	PMID:27235368
Biological Process	GO:0043330	response to exogenous dsRNA	mxc	IDA		Zfish	PMID:19201835
Biological Process	GO:0035455	response to interferon-alpha	MX2	IDA		Human	PMID:24121441
Biological Process	GO:0009615	response to virus	MX1	IMP		Human	PMID:15047845
Biological Process	GO:0009615	response to virus	MX2	IDA		Human	PMID:24048477
Biological Process	GO:0009615	response to virus	Mx2	IDA		Rat	PMID:2173790|RGD:728936
Biological Process	GO:0009615	response to virus	mxe	IDA		Zfish	PMID:17371995
Biological Process	GO:0009615	response to virus	mxa	IDA		Zfish	PMID:17400579
Biological Process	GO:0009615	response to virus	mxa	IDA		Zfish	PMID:25746990
Biological Process	GO:0009615	response to virus	mxa	IDA		Zfish	PMID:27235368
Biological Process	GO:0009615	response to virus	mxa	IDA		Zfish	PMID:16007375
Biological Process	GO:0009615	response to virus	mxa	IDA		Zfish	PMID:17371995
Biological Process	GO:0009615	response to virus	mxb	IDA		Zfish	PMID:17371995
Biological Process	GO:0009615	response to virus	mxc	IDA		Zfish	PMID:17371995

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern