Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MXD4
  • Mouse genes Mxd4
  • Rat genes Mxd4
  • Zfish genes mxd4
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Mxd4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003677	DNA binding	Mxd4	IDA		Mouse	PMID:8521822
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	Mxd4	IDA		Mouse	MGI:MGI:77472|PMID:8521822
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	Mxd4	IMP		Mouse	MGI:MGI:77472|PMID:8521822
Molecular Function	GO:0005515	protein binding	MXD4	IPI	UniProtKB:Q8TDR4	Human	PMID:15469726
Molecular Function	GO:0005515	protein binding	MXD4	IPI	UniProtKB:Q8TDR4	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	Mxd4	IPI	PR:P28574-2	Mouse	PMID:10229200
Molecular Function	GO:0005515	protein binding	Mxd4	IPI	PR:P28574	Mouse	PMID:8521822
Molecular Function	GO:0005515	protein binding	Mxd4	IPI	PR:Q60520	Mouse	PMID:8521822
Molecular Function	GO:0005515	protein binding	Mxd4	IPI	PR:Q62141	Mouse	PMID:8521822
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	Mxd4	IMP		Mouse	MGI:MGI:77472|PMID:8521822
Cellular Component	GO:0090575	RNA polymerase II transcription regulator complex	Mxd4	IMP		Mouse	MGI:MGI:77472|PMID:8521822
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Mxd4	IGI	MGI:MGI:97250	Mouse	PMID:8521822
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Mxd4	IGI	MGI:MGI:96921	Mouse	PMID:8521822
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Mxd4	IDA		Mouse	MGI:MGI:77472|PMID:8521822

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern