Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MYCN
  • Mouse genes Mycn
  • Rat genes Mycn
  • Zfish genes mycn
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Mycn

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	MYCN	IDA		Human	PMID:17327229
Molecular Function	GO:0019900	kinase binding	MYCN	IPI	UniProtKB:O14965	Human	PMID:27837025
Molecular Function	GO:0005515	protein binding	MYCN	IPI	UniProtKB:P61244	Human	PMID:10597290
Molecular Function	GO:0005515	protein binding	MYCN	IPI	UniProtKB:Q13287	Human	PMID:10597290
Molecular Function	GO:0005515	protein binding	MYCN	IPI	UniProtKB:Q8IY57	Human	PMID:11593398
Molecular Function	GO:0005515	protein binding	MYCN	IPI	UniProtKB:Q8N726	Human	PMID:17289033
Molecular Function	GO:0005515	protein binding	MYCN	IPI	UniProtKB:P61244	Human	PMID:18003922
Molecular Function	GO:0005515	protein binding	MYCN	IPI	UniProtKB:O14965	Human	PMID:19111882
Molecular Function	GO:0005515	protein binding	MYCN	IPI	UniProtKB:Q96EB6	Human	PMID:21698133
Molecular Function	GO:0005515	protein binding	MYCN	IPI	UniProtKB:O14965	Human	PMID:23792191
Molecular Function	GO:0005515	protein binding	MYCN	IPI	UniProtKB:P61244	Human	PMID:23792191
Molecular Function	GO:0005515	protein binding	MYCN	IPI	UniProtKB:O14965	Human	PMID:25175806
Molecular Function	GO:0005515	protein binding	MYCN	IPI	UniProtKB:P61244	Human	PMID:25175806
Molecular Function	GO:0005515	protein binding	MYCN	IPI	UniProtKB:Q13105	Human	PMID:26766587
Molecular Function	GO:0005515	protein binding	MYCN	IPI	UniProtKB:O14965	Human	PMID:27728805
Molecular Function	GO:0005515	protein binding	MYCN	IPI	UniProtKB:P61244	Human	PMID:27728805
Molecular Function	GO:0005515	protein binding	MYCN	IPI	UniProtKB:Q969H0	Human	PMID:27837025
Molecular Function	GO:0005515	protein binding	Mycn	IPI	PR:P28574-2	Mouse	PMID:10229200
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	MYCN	IDA		Human	PMID:17327229
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	MYCN	IDA		Human	PMID:28473536
Cellular Component	GO:0005730	nucleolus	MYCN	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	MYCN	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	MYCN	IDA		Human	PMID:10597290
Cellular Component	GO:0005634	nucleus	Mycn	IDA		Mouse	PMID:19796622
Cellular Component	GO:0005634	nucleus	Mycn	IDA		Mouse	PMID:15716345
Biological Process	GO:0048708	astrocyte differentiation	Mycn	IDA		Mouse	PMID:18640244
Biological Process	GO:0048754	branching morphogenesis of an epithelial tube	Mycn	IMP	MGI:MGI:2388717,MGI:MGI:3574949	Mouse	PMID:15716345
Biological Process	GO:0001502	cartilage condensation	Mycn	IMP		Mouse	PMID:17360777
Biological Process	GO:0008283	cell population proliferation	Mycn	IMP	MGI:MGI:2388717,MGI:MGI:3574949	Mouse	PMID:15716345
Biological Process	GO:0042733	embryonic digit morphogenesis	Mycn	IMP		Mouse	PMID:17360777
Biological Process	GO:0048704	embryonic skeletal system morphogenesis	Mycn	IMP		Mouse	PMID:17360777
Biological Process	GO:0050673	epithelial cell proliferation	Mycn	IMP	MGI:MGI:2388717,MGI:MGI:3574949	Mouse	PMID:15716345
Biological Process	GO:0030324	lung development	Mycn	IMP	MGI:MGI:2388717,MGI:MGI:3574949	Mouse	PMID:15716345
Biological Process	GO:0048712	negative regulation of astrocyte differentiation	Mycn	IDA		Mouse	PMID:18640244
Biological Process	GO:0010629	negative regulation of gene expression	MYCN	IDA		Human	PMID:21796614
Biological Process	GO:2000378	negative regulation of reactive oxygen species metabolic process	Mycn	IDA		Mouse	MGI:MGI:5050076|PMID:17357786
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	MYCN	IMP		Human	PMID:24391509
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Mycn	IDA		Mouse	MGI:MGI:5050076|PMID:17357786
Biological Process	GO:0050679	positive regulation of epithelial cell proliferation	Mycn	IMP	MGI:MGI:2388717,MGI:MGI:3574949	Mouse	PMID:15716345
Biological Process	GO:0010628	positive regulation of gene expression	MYCN	IDA		Human	PMID:23308108
Biological Process	GO:0002053	positive regulation of mesenchymal cell proliferation	Mycn	IMP		Mouse	PMID:17360777
Biological Process	GO:0043068	positive regulation of programmed cell death	Mycn	IMP		Mouse	PMID:17360777
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	MYCN	IDA		Human	PMID:17327229
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Mycn	IMP		Mouse	MGI:MGI:5009774|PMID:21047779
Biological Process	GO:0045607	regulation of inner ear auditory receptor cell differentiation	Mycn	IGI	MGI:MGI:96799	Mouse	PMID:23022312

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern